BE904831A - Composition d'activateur tissulaire du plasminogene. - Google Patents
Composition d'activateur tissulaire du plasminogene.Info
- Publication number
- BE904831A BE904831A BE0/216712A BE216712A BE904831A BE 904831 A BE904831 A BE 904831A BE 0/216712 A BE0/216712 A BE 0/216712A BE 216712 A BE216712 A BE 216712A BE 904831 A BE904831 A BE 904831A
- Authority
- BE
- Belgium
- Prior art keywords
- amino acid
- activator composition
- tissue activator
- plasminogen tissue
- acid sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Solution aqueuse parentérale d'un pH de 2 à 5 contenant du t-PA mono- ou bicaténaire qui a la séquence des aminoacides à laFig. 1 ou a la meme séquence des aminoacides, mais dont l'aminoacide à la position 245 à partir de l'extrémité N-terminale de la sérine est la valine au lieu de la méthionine, l'une ou l'autre séquence étant éventuellement exempte de l'un quelconque des trois premiers aminoacides ou comprenant éventuellement une préséquence de Gly-Ala-Arg supplémentaire N-terminale du polypeptide.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858513358A GB8513358D0 (en) | 1985-05-28 | 1985-05-28 | Formulation |
GB858521704A GB8521704D0 (en) | 1985-08-31 | 1985-08-31 | Formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
BE904831A true BE904831A (fr) | 1986-11-27 |
Family
ID=26289289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/216712A BE904831A (fr) | 1985-05-28 | 1986-05-27 | Composition d'activateur tissulaire du plasminogene. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5112609A (fr) |
AT (1) | AT391812B (fr) |
AU (1) | AU569429B2 (fr) |
BE (1) | BE904831A (fr) |
CA (1) | CA1297008C (fr) |
CH (1) | CH664495A5 (fr) |
DE (1) | DE3617753A1 (fr) |
DK (1) | DK163174C (fr) |
ES (1) | ES8706443A1 (fr) |
FI (1) | FI85334C (fr) |
FR (1) | FR2593393B1 (fr) |
GB (1) | GB2176703B (fr) |
GR (1) | GR861365B (fr) |
HU (1) | HU200695B (fr) |
IL (1) | IL78937A (fr) |
IT (1) | IT1191925B (fr) |
LU (1) | LU86445A1 (fr) |
NL (1) | NL8601354A (fr) |
NO (1) | NO171344C (fr) |
NZ (1) | NZ216306A (fr) |
PT (1) | PT82647B (fr) |
SE (1) | SE462893B (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5185259A (en) * | 1982-05-05 | 1993-02-09 | Genentech, Inc. | Truncated human tissue plasminogen activator |
FI831484L (fi) * | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
GT198302091A (es) * | 1982-05-05 | 1984-10-25 | Activador de plasminogeno de tejido humano a),b),c). | |
HUT41632A (en) * | 1985-03-06 | 1987-05-28 | Survival Technology | Process for preparing agents for the enhancement of protein absorption |
ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
LU86875A1 (fr) * | 1986-05-12 | 1988-01-20 | Wellcome Found | Utilisation de l'activateur tissulaire du plasminogene,son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association |
US4976959A (en) * | 1986-05-12 | 1990-12-11 | Burroughs Wellcome Co. | T-PA and SOD in limiting tissue damage |
GB8619098D0 (en) * | 1986-08-05 | 1986-09-17 | Wellcome Found | Combination |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
GB8814604D0 (en) * | 1988-06-20 | 1988-07-27 | Wellcome Found | Medicaments |
WO1990001334A1 (fr) * | 1988-08-05 | 1990-02-22 | Codon | Formules d'activateur du plasminogene a base d'aspartate |
GB8819607D0 (en) * | 1988-08-17 | 1988-09-21 | Wellcome Found | Novel combination |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
GB9000629D0 (en) * | 1990-01-11 | 1990-03-14 | Porton Prod Ltd | Tissue plasminogen activator |
AU664469B2 (en) * | 1992-06-03 | 1995-11-16 | Genentech Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
EP0827751B1 (fr) * | 1996-09-06 | 2003-02-26 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Composition médicinale qui contient de l'activateur de plasminogène tissulaire et de la nicotinamide |
US7544500B2 (en) | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
US20030077682A1 (en) * | 2001-09-07 | 2003-04-24 | Hung Paul Porwen | Human tissue urokinase type plasminogen activator formulation |
CA2726908C (fr) * | 2008-06-04 | 2017-01-24 | Talecris Biotherapeutics, Inc. | Composition, methode et necessaire pour la preparation de plasmine |
JP5789521B2 (ja) | 2009-03-03 | 2015-10-07 | グリフオルス・セラピユーテイクス・インコーポレーテツドGrifols Therapeutics,Inc. | プラスミノーゲンを製造するための組成物、方法およびキット;ならびにそれから製造されるプラスミン |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3998947A (en) * | 1973-11-30 | 1976-12-21 | Pierre Fabre S.A. | Process for obtaining a plasminogen activator |
FR2252842B1 (fr) * | 1973-12-03 | 1977-11-04 | Fabre Sa Pierre | |
DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
CA1154671A (fr) * | 1979-07-27 | 1983-10-04 | Lucien D. D'hinterland | Separation d'un activateur tissulaire du plasminogene |
NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
ZA831399B (en) * | 1982-03-05 | 1984-02-29 | Health Lab Service Board | New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them |
IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
NL191755C (nl) * | 1982-10-29 | 1996-07-02 | Mitsui Toatsu Chemicals | Plasminogeenactivator en trombolytisch middel. |
AU554862B2 (en) * | 1982-12-14 | 1986-09-04 | Implico B.V. | Plasminogen activator isolated by affinity chromatography |
DE3382389D1 (de) * | 1982-12-14 | 1991-10-02 | South African Inventions | Plasminogenaktivator. |
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
EP0156169B1 (fr) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | Solution aqueuse d'un activateur tissulaire du plasminogène dissous à une concentration élevée et un procédé d'obtention |
DE3439980A1 (de) * | 1984-11-02 | 1986-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung sowie pasteurisierung von urokinase |
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
EP0417662B1 (fr) * | 1989-09-13 | 1995-12-13 | Maschinenfabrik Rieter Ag | Procédé pour commencer le cycle de travail d'un chariot de surveillance dans une machine textile |
-
1986
- 1986-05-27 PT PT82647A patent/PT82647B/pt not_active IP Right Cessation
- 1986-05-27 CA CA000510096A patent/CA1297008C/fr not_active Expired - Fee Related
- 1986-05-27 GR GR861365A patent/GR861365B/el unknown
- 1986-05-27 DE DE19863617753 patent/DE3617753A1/de active Granted
- 1986-05-27 NL NL8601354A patent/NL8601354A/nl not_active Application Discontinuation
- 1986-05-27 SE SE8602404A patent/SE462893B/sv not_active IP Right Cessation
- 1986-05-27 HU HU862239A patent/HU200695B/hu not_active IP Right Cessation
- 1986-05-27 DK DK246886A patent/DK163174C/da not_active IP Right Cessation
- 1986-05-27 CH CH2127/86A patent/CH664495A5/de not_active IP Right Cessation
- 1986-05-27 NO NO862095A patent/NO171344C/no unknown
- 1986-05-27 LU LU86445A patent/LU86445A1/fr unknown
- 1986-05-27 BE BE0/216712A patent/BE904831A/fr not_active IP Right Cessation
- 1986-05-27 NZ NZ216306A patent/NZ216306A/xx unknown
- 1986-05-27 AT AT0141186A patent/AT391812B/de not_active IP Right Cessation
- 1986-05-27 GB GB08612781A patent/GB2176703B/en not_active Expired
- 1986-05-27 IL IL78937A patent/IL78937A/xx not_active IP Right Cessation
- 1986-05-27 AU AU57965/86A patent/AU569429B2/en not_active Ceased
- 1986-05-27 IT IT48064/86A patent/IT1191925B/it active
- 1986-05-27 FR FR8607553A patent/FR2593393B1/fr not_active Expired
- 1986-05-27 ES ES555352A patent/ES8706443A1/es not_active Expired
- 1986-05-27 FI FI862226A patent/FI85334C/fi not_active IP Right Cessation
-
1990
- 1990-05-21 US US07/527,634 patent/US5112609A/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE904831A (fr) | Composition d'activateur tissulaire du plasminogene. | |
US4530787B1 (fr) | ||
ES2196031T3 (es) | Derivados peptidicos terapeutico. | |
ES2125718T3 (es) | Purificacion de corriente de subproducto en la preparacion de poliesteres a base de 1,3-propanodiol. | |
FR2591485B1 (fr) | Compositions stabilisees contenant l'activateur du plasminogene du tissu humain. | |
KR870006188A (ko) | 과립구 대식세포 콜로니 촉진 인자(gm-csf) 단백질의 제조방법 | |
LV12000A (lv) | Olbaltumviela ar uratoksidazes aktivitati un tas iegusana | |
SE8901552D0 (sv) | Acid addition salts of amidated or glycine, their preparation and use | |
DK0639202T3 (da) | Stabil polypeptidsammensætning | |
EP0326490A3 (en) | Synthetic peptides and mixtures thereof for detecting hiv antibodies | |
ZA823339B (en) | Purification or enrichment of biologically active proteins and agent therefor | |
KR950005325A (ko) | 제약 조성물 | |
EA200001252A1 (ru) | КОМПОЗИЦИЯ РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА-β-1A(IFN-β-1A) ЧЕЛОВЕКА | |
ATE93731T1 (de) | Protein enthaltende waesserige loesungen. | |
AU637997B2 (en) | Pentamidine solutions for preventing pneumocystis carinii pneumonia | |
PT84011A (fr) | Procede de preparation de nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant de calcium de l:organisme | |
ATE432985T1 (de) | Polypeptide mit aktivität der stimulierung von neutrophilen | |
KR970006314A (ko) | 항균성 및 항진균성 활성을 갖는 폴리펩타이드 | |
SU1290679A1 (ru) | (n,n'-бисдиэтаноламинометилен)диамиды карбоновых кислот в качестве дубителей и пластификаторов фотографических желатиновых галогенсеребряных слоев | |
DK661888A (da) | Biologisk aktive molekyler | |
KR950032619A (ko) | 변형된 인간 적혈구 성장 촉진 인자 유전자 및 그의 발현벡터 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LTD Effective date: 19950531 |