DK163174C - Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf - Google Patents

Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf

Info

Publication number
DK163174C
DK163174C DK246886A DK246886A DK163174C DK 163174 C DK163174 C DK 163174C DK 246886 A DK246886 A DK 246886A DK 246886 A DK246886 A DK 246886A DK 163174 C DK163174 C DK 163174C
Authority
DK
Denmark
Prior art keywords
procedures
preparing
tissue plasminogen
parenteral solution
activates
Prior art date
Application number
DK246886A
Other languages
Danish (da)
English (en)
Other versions
DK246886A (da
DK246886D0 (da
DK163174B (da
Inventor
Michael Denis Johnston
Henry Berger
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521704A external-priority patent/GB8521704D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK246886D0 publication Critical patent/DK246886D0/da
Publication of DK246886A publication Critical patent/DK246886A/da
Publication of DK163174B publication Critical patent/DK163174B/da
Application granted granted Critical
Publication of DK163174C publication Critical patent/DK163174C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
DK246886A 1985-05-28 1986-05-27 Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf DK163174C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB8513358 1985-05-28
GB8521704 1985-08-31
GB858521704A GB8521704D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (4)

Publication Number Publication Date
DK246886D0 DK246886D0 (da) 1986-05-27
DK246886A DK246886A (da) 1986-11-29
DK163174B DK163174B (da) 1992-02-03
DK163174C true DK163174C (da) 1992-06-22

Family

ID=26289289

Family Applications (1)

Application Number Title Priority Date Filing Date
DK246886A DK163174C (da) 1985-05-28 1986-05-27 Vandig koncentreret parenteral oploesning af vaevs-plasminogenaktivater (t-pa) og fremgangsmaade til fremstilling heraf

Country Status (22)

Country Link
US (1) US5112609A (enExample)
AT (1) AT391812B (enExample)
AU (1) AU569429B2 (enExample)
BE (1) BE904831A (enExample)
CA (1) CA1297008C (enExample)
CH (1) CH664495A5 (enExample)
DE (1) DE3617753A1 (enExample)
DK (1) DK163174C (enExample)
ES (1) ES8706443A1 (enExample)
FI (1) FI85334C (enExample)
FR (1) FR2593393B1 (enExample)
GB (1) GB2176703B (enExample)
GR (1) GR861365B (enExample)
HU (1) HU200695B (enExample)
IL (1) IL78937A (enExample)
IT (1) IT1191925B (enExample)
LU (1) LU86445A1 (enExample)
NL (1) NL8601354A (enExample)
NO (1) NO171344C (enExample)
NZ (1) NZ216306A (enExample)
PT (1) PT82647B (enExample)
SE (1) SE462893B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI831484A7 (fi) * 1982-05-05 1983-11-06 Genentech Inc Ihmiskudoksen plasminogeenien aktivaattori.
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
WO1986005096A1 (en) * 1985-03-06 1986-09-12 Survival Technology, Inc. Protein absorption enhancing agents
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
JPH0680015B2 (ja) * 1986-05-12 1994-10-12 ザ ウエルカム ファウンデーション リミテッド 医薬組成物
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
GB8814604D0 (en) * 1988-06-20 1988-07-27 Wellcome Found Medicaments
WO1990001334A1 (en) * 1988-08-05 1990-02-22 Codon Formulations for plasminogen activator using aspartate
GB8819607D0 (en) * 1988-08-17 1988-09-21 Wellcome Found Novel combination
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
GB9000629D0 (en) * 1990-01-11 1990-03-14 Porton Prod Ltd Tissue plasminogen activator
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
DE69719265T2 (de) * 1996-09-06 2003-12-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
HUE025670T2 (en) 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (enExample) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
ES8106836A2 (es) * 1979-07-27 1981-10-01 Fabre Sa Pierre Procedimiento de obtencion de un activador del plasminogeno
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
ZA831399B (en) * 1982-03-05 1984-02-29 Health Lab Service Board New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
DE59009964D1 (de) * 1989-09-13 1996-01-25 Rieter Ag Maschf Verfahren zum Starten eines Arbeitsablaufs eines Bedienungsautomaten an einer Textilmaschine

Also Published As

Publication number Publication date
IL78937A0 (en) 1986-09-30
ES555352A0 (es) 1987-07-01
NO171344C (no) 1993-03-03
SE8602404L (sv) 1986-11-29
LU86445A1 (fr) 1986-12-05
GB8612781D0 (en) 1986-07-02
FI85334B (fi) 1991-12-31
NO171344B (no) 1992-11-23
US5112609A (en) 1992-05-12
FI862226L (fi) 1986-11-29
AT391812B (de) 1990-12-10
GR861365B (en) 1986-09-29
IT8648064A0 (it) 1986-05-27
DK246886A (da) 1986-11-29
NO862095L (no) 1986-12-01
SE8602404D0 (sv) 1986-05-27
NL8601354A (nl) 1986-12-16
DE3617753A1 (de) 1986-12-04
DK246886D0 (da) 1986-05-27
ATA141186A (de) 1990-06-15
FI862226A0 (fi) 1986-05-27
DE3617753C2 (enExample) 1988-06-30
GB2176703B (en) 1988-12-07
HU200695B (en) 1990-08-28
BE904831A (fr) 1986-11-27
FI85334C (fi) 1992-04-10
FR2593393B1 (fr) 1989-06-02
ES8706443A1 (es) 1987-07-01
SE462893B (sv) 1990-09-17
CA1297008C (en) 1992-03-10
CH664495A5 (de) 1988-03-15
FR2593393A1 (fr) 1987-07-31
PT82647A (en) 1986-06-01
DK163174B (da) 1992-02-03
AU5796586A (en) 1986-12-04
GB2176703A (en) 1987-01-07
HUT42330A (en) 1987-07-28
AU569429B2 (en) 1988-01-28
IT1191925B (it) 1988-03-31
IL78937A (en) 1990-11-29
NZ216306A (en) 1989-10-27
PT82647B (pt) 1989-01-30

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