US5691181A
(en)
*
|
1984-08-21 |
1997-11-25 |
Celltech Limited |
DNA encoding lipase from human gastric mucosal tissue
|
EP0193112A3
(en)
*
|
1985-02-22 |
1987-02-25 |
The Trustees Of Columbia University In The City Of New York |
Cdna encoding mammalian insulin-like growth factor ii
|
US5242811A
(en)
*
|
1985-03-26 |
1993-09-07 |
Biogen, Inc. |
Production of human somatomedin C
|
ZA866026B
(en)
*
|
1985-08-12 |
1988-04-27 |
Syntex Inc |
Bovine growth hormone releasing factor derivative
|
EP0213472A1
(en)
*
|
1985-08-12 |
1987-03-11 |
Syntex (U.S.A.) Inc. |
Method for producing fusion proteins
|
EP0212532A1
(en)
*
|
1985-08-12 |
1987-03-04 |
Syntex (U.S.A.) Inc. |
Method for producing fusion proteins
|
US5496924A
(en)
*
|
1985-11-27 |
1996-03-05 |
Hoechst Aktiengesellschaft |
Fusion protein comprising an interleukin-2 fragment ballast portion
|
US5359035A
(en)
*
|
1985-12-21 |
1994-10-25 |
Hoechst Aktiengesellschaft |
Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
|
US5019559A
(en)
*
|
1986-11-14 |
1991-05-28 |
President And Fellows Of Harvard College |
Wound healing using PDGF and IGF-II
|
US4861757A
(en)
*
|
1986-11-14 |
1989-08-29 |
Institute Of Molecular Biology |
Wound healing and bone regeneration using PDGF and IGF-I
|
US5270180A
(en)
*
|
1986-12-31 |
1993-12-14 |
Lucky, Ltd. |
Method for the production of salmon growth hormone using a synthetic gene
|
US5200509A
(en)
*
|
1987-04-06 |
1993-04-06 |
Celtrix Pharmaceuticals, Inc. |
Human somatomedin carrier protein subunits and process for producing them; recombinant DNA molecules, hosts, processes and human somatomedin carrier protein-like polypeptides
|
US5084384A
(en)
*
|
1987-04-23 |
1992-01-28 |
Monsanto Company |
Secretion of insulin-like growth factor-I
|
US5256644A
(en)
*
|
1988-05-20 |
1993-10-26 |
Institute Of Molecular Biology, Inc. |
Wound healing using IGF-II and TGF
|
US4983581A
(en)
*
|
1988-05-20 |
1991-01-08 |
Institute Of Molecular Biology, Inc. |
Wound healing composition of IGF-I and TGF-β
|
DE3834079A1
(de)
*
|
1988-10-06 |
1990-04-12 |
Biotechnolog Forschung Gmbh |
Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
|
IL92816A0
(en)
*
|
1988-12-22 |
1990-09-17 |
Biogrowth Inc |
Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides
|
JPH0722517B2
(ja)
*
|
1989-08-24 |
1995-03-15 |
株式会社三和化学研究所 |
モチリン様ポリペプチドの製法並びにそのための組換えdna及び発現用プラスミド
|
WO1990010069A1
(en)
*
|
1989-02-28 |
1990-09-07 |
Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr |
RECOMBINANT PLASMID DNA pAA 1213-23 AND pAC 262-33 CODING FOR SYNTHESIS OF HUMAN INTERLEUKIN-2, METHOD OF THEIR CONSTRUCTION AND STRAIN OF BACTERIA ESCHERICHIA COLI RRI/pAC 262-33 AS PRODUCER OF HUMAN INTERLEUKIN-2
|
US5171670A
(en)
*
|
1989-05-12 |
1992-12-15 |
The General Hospital Corporation |
Recombinant dna method for production of parathyroid hormone
|
USRE37919E1
(en)
|
1989-05-12 |
2002-12-03 |
The General Hospital Corporation |
Recombinant DNA method for production of parathyroid hormone
|
GB8927008D0
(en)
*
|
1989-11-29 |
1990-01-17 |
Ciba Geigy |
Novel process for the production of unfused protein in e.coli
|
WO1991018622A1
(en)
*
|
1990-05-30 |
1991-12-12 |
President And Fellows Of Harvard College |
Wound healing
|
EP0785273A1
(en)
|
1990-11-26 |
1997-07-23 |
Genetics Institute, Inc. |
Paired basic amino acid converting enzyme and DNA sequence encoding it
|
SE9100099D0
(sv)
*
|
1991-01-11 |
1991-01-11 |
Kabi Pharmacia Ab |
Use of growth factor
|
US5977070A
(en)
*
|
1992-07-14 |
1999-11-02 |
Piazza; Christin Teresa |
Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
|
US5589452A
(en)
*
|
1992-07-14 |
1996-12-31 |
Syntex (U.S.A.) Inc. |
Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
|
US5464934A
(en)
*
|
1993-05-14 |
1995-11-07 |
Mallinckrodt Medical, Inc. |
Metal chelates as spacer compounds in biologically active peptides
|
US5407810A
(en)
*
|
1993-08-20 |
1995-04-18 |
Genentech, Inc. |
Aqueous multiple-phase isolation of polypeptide
|
US5663304A
(en)
*
|
1993-08-20 |
1997-09-02 |
Genentech, Inc. |
Refolding of misfolded insulin-like growth factor-I
|
US5446024A
(en)
*
|
1993-12-17 |
1995-08-29 |
Genentech, Inc. |
Purification of insulin-like growth factor
|
US5629167A
(en)
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
EP0779927A1
(en)
*
|
1994-09-08 |
1997-06-25 |
Chiron Corporation |
A method of improved production of insulin-like growth factor
|
US5728676A
(en)
*
|
1994-09-08 |
1998-03-17 |
Ciba-Geigy Corporation |
Use of insulin-like growth factors I and II for inhibition of inflammatory response
|
HUP0001650A3
(en)
*
|
1996-11-08 |
2001-09-28 |
Neose Technologies Inc Horsham |
Improved expression vectors
|
NZ335207A
(en)
|
1996-11-15 |
2000-09-29 |
Genentech Inc |
Process to isolate recombinant human neurotrophin using hydrophobic chromatography resin
|
US6265542B1
(en)
|
1997-10-24 |
2001-07-24 |
Genentech, Inc. |
Purification of molecules
|
CA2671261A1
(en)
|
1997-11-06 |
1999-05-20 |
Novartis Vaccines And Diagnostics S.R.L. |
Neisserial antigens
|
ATE446368T1
(de)
|
1998-01-14 |
2009-11-15 |
Novartis Vaccines & Diagnostic |
Antigene aus neisseria meningitidis
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
EP2261355A3
(en)
|
1998-05-01 |
2012-01-11 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
DK1228217T3
(da)
|
1999-04-30 |
2013-02-25 |
Novartis Vaccines & Diagnostic |
Konserverede neisseria-antigener
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
CA2864069A1
(en)
|
1999-10-29 |
2001-05-03 |
Novartis Vaccines And Diagnostics S.R.L. |
Neisserial antigenic peptides
|
ES2507100T3
(es)
|
2000-01-17 |
2014-10-14 |
Novartis Vaccines And Diagnostics S.R.L. |
Vacuna OMV suplementada contra meningococo
|
FR2810675B1
(fr)
*
|
2000-06-22 |
2002-09-27 |
Pf Medicament |
Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes
|
EP1315513B1
(en)
*
|
2000-09-08 |
2011-03-09 |
Amylin Pharmaceuticals, Inc. |
"pseudo"-native chemical ligation
|
EP2189473A3
(en)
|
2000-10-27 |
2010-08-11 |
Novartis Vaccines and Diagnostics S.r.l. |
Nucleic and proteins from streptococcus groups A & B
|
AU3944002A
(en)
|
2000-11-03 |
2002-05-27 |
Genentech Inc |
Metabolic rate shifts in fermentations expressing recombinant proteins
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
MXPA04000653A
(es)
|
2001-07-27 |
2004-11-22 |
Chiron Srl |
Adhesinas de meningococcus nada, app y orf 40.
|
JP4413617B2
(ja)
|
2001-12-12 |
2010-02-10 |
カイロン ソチエタ ア レスポンサビリタ リミタータ |
Chlamydiatrachomatisに対する免疫化
|
EP1572720A4
(en)
*
|
2002-05-24 |
2008-12-24 |
Nps Allelix Corp |
PROCESS FOR THE ENZYMATIC PRODUCTION OF GLP-2 (1-34) AND GLP-2 (1-33) PEPTIDES
|
AU2003239865A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Restoragen Inc. |
Method for universal enzymatic production of bioactive peptides
|
AU2003239894A1
(en)
|
2002-05-24 |
2003-12-12 |
Restoragen Inc. |
Methods and constructs for high yield expression of clostripain
|
AU2003231862A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Restoragen, Inc. |
Methods and dna constructs for high yield production of polypeptides
|
AU2003239863A1
(en)
*
|
2002-05-24 |
2003-12-12 |
Restoragen Inc. |
Method for enzymatic production of glp-1 (7-36) amide peptides
|
CA2506318C
(en)
|
2002-11-15 |
2011-07-12 |
Chiron Srl |
Unexpected surface proteins in neisseria meningitidis
|
GB0227346D0
(en)
|
2002-11-22 |
2002-12-31 |
Chiron Spa |
741
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
WO2004096992A2
(en)
|
2003-04-25 |
2004-11-11 |
North Carolina State University |
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
|
WO2005001057A2
(en)
|
2003-06-23 |
2005-01-06 |
North Carolina State University |
Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
|
PL1704234T3
(pl)
*
|
2003-11-21 |
2012-06-29 |
Nps Pharma Inc |
Wytwarzanie glukagonopodobnego peptydu 2 i analogów
|
MXPA06008496A
(es)
|
2004-02-02 |
2007-01-30 |
Ambrx Inc |
Polipeptidos de interferon humano modificados y sus usos.
|
US7459289B2
(en)
|
2004-03-08 |
2008-12-02 |
North Carolina State University |
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
|
MXPA06014684A
(es)
*
|
2004-06-18 |
2007-02-12 |
Ambrx Inc |
Novedosos polipeptidos de enlace antigeno y sus usos.
|
WO2009100255A2
(en)
|
2008-02-08 |
2009-08-13 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
KR20070039593A
(ko)
*
|
2004-07-21 |
2007-04-12 |
암브룩스, 인코포레이티드 |
비천연적으로 코딩된 아미노산을 이용한 생합성 폴리펩티드
|
EP1833970A2
(en)
*
|
2004-12-22 |
2007-09-19 |
Genentech, Inc. |
Methods for producing soluble multi-membrane-spanning proteins
|
BRPI0518661A2
(pt)
|
2004-12-22 |
2008-12-02 |
Ambrx Inc |
mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante
|
ATE541934T1
(de)
*
|
2004-12-22 |
2012-02-15 |
Ambrx Inc |
Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon
|
KR101224781B1
(ko)
|
2004-12-22 |
2013-01-21 |
암브룩스, 인코포레이티드 |
비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물
|
US7638491B2
(en)
|
2004-12-22 |
2009-12-29 |
Ambrx, Inc. |
Therapies using non-natural amino acids and polypeptides
|
MX2007007580A
(es)
*
|
2004-12-22 |
2007-12-11 |
Ambrx Inc |
Hormona del crecimiento humana modificada.
|
WO2006113475A2
(en)
|
2005-04-15 |
2006-10-26 |
North Carolina State University |
Methods and compositions to modulate adhesion and stress tolerance in bacteria
|
EP1893229B1
(en)
*
|
2005-06-03 |
2011-10-19 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
AU2005335491B2
(en)
*
|
2005-08-18 |
2010-11-25 |
Ambrx, Inc. |
Compositions of tRNA and uses thereof
|
AU2006311568B2
(en)
*
|
2005-11-08 |
2010-11-11 |
Ambrx, Inc. |
Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
|
PT2339014E
(pt)
*
|
2005-11-16 |
2015-10-13 |
Ambrx Inc |
Métodos e composições compreendendo aminoácidos não-naturais
|
GB0524066D0
(en)
|
2005-11-25 |
2006-01-04 |
Chiron Srl |
741 ii
|
EP1968635B1
(en)
*
|
2005-12-14 |
2014-09-17 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
PL2054431T3
(pl)
|
2006-06-09 |
2012-07-31 |
Novartis Ag |
Konformery adhezyn bakteryjnych
|
WO2008005533A2
(en)
*
|
2006-07-06 |
2008-01-10 |
Aaron Thomas Tabor |
Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
|
US8420792B2
(en)
*
|
2006-09-08 |
2013-04-16 |
Ambrx, Inc. |
Suppressor tRNA transcription in vertebrate cells
|
CA2662753C
(en)
*
|
2006-09-08 |
2016-02-23 |
Ambrx, Inc. |
Hybrid suppressor trna for vertebrate cells
|
CN106008699A
(zh)
*
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
EP2068909B1
(en)
|
2007-03-30 |
2012-04-25 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
AU2008247815B2
(en)
*
|
2007-05-02 |
2012-09-06 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
JP5547083B2
(ja)
*
|
2007-11-20 |
2014-07-09 |
アンブルックス,インコーポレイテッド |
修飾されたインスリンポリペプチドおよびそれらの使用
|
US9579372B2
(en)
|
2008-02-21 |
2017-02-28 |
Glaxosmithkline Biologicals Sa |
Meningococcal fHBP polypeptides
|
US10138283B2
(en)
|
2008-07-23 |
2018-11-27 |
Ambrx, Inc. |
Modified bovine G-CSF polypeptides and their uses
|
CN107022020A
(zh)
|
2008-09-26 |
2017-08-08 |
Ambrx公司 |
修饰的动物促红细胞生成素多肽和其用途
|
MX348657B
(es)
|
2008-09-26 |
2017-06-21 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
BR112012000865A2
(pt)
|
2009-07-17 |
2019-09-24 |
T Tabor Aaron |
"composição e método para a modificação genética cosmética de células substancialmente intactas"
|
CN104650241A
(zh)
|
2009-08-27 |
2015-05-27 |
诺华股份有限公司 |
包括脑膜炎球菌fHBP序列的杂交多肽
|
CA2779816A1
(en)
|
2009-10-27 |
2011-05-05 |
Novartis Ag |
Modified meningococcal fhbp polypeptides
|
AU2010341516B2
(en)
|
2009-12-21 |
2014-01-16 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
CA2784800A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
US9040302B2
(en)
|
2010-05-19 |
2015-05-26 |
North Carolina State University |
Genetically modified Streptococcus thermophilus bacterium
|
SG10201506443TA
(en)
|
2010-08-17 |
2015-10-29 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
US10767156B2
(en)
|
2013-10-24 |
2020-09-08 |
Yeda Research And Development Co., Ltd. |
Polynucleotides encoding BREX system polypeptides and methods of using same
|
LT3412302T
(lt)
|
2014-10-24 |
2021-07-26 |
Bristol-Myers Squibb Company |
Modifikuoti fgf-21 polipeptidai ir jų panaudojimai
|
US10590426B2
(en)
|
2016-08-22 |
2020-03-17 |
Board Of Trustees Of Michigan State University |
Genetic control of cell size
|
IL250479A0
(en)
|
2017-02-06 |
2017-03-30 |
Sorek Rotem |
Genetically engineered cells expressing a disarm system that confers resistance to phages and methods for their production
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
IL258467A
(en)
|
2018-03-29 |
2018-07-04 |
Ilana Kolodkin Gal |
Methods of disrupting a biofilm and/or preventing formation of same
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
US20220175807A1
(en)
|
2019-03-31 |
2022-06-09 |
Yeda Research And Development Co. Ltd. |
Anti-viral and anti-tumoral compounds
|
KR20220151202A
(ko)
|
2020-03-11 |
2022-11-14 |
암브룩스, 인코포레이티드 |
인터류킨-2 폴리펩타이드 접합체 및 그의 사용 방법
|
IL288680A
(en)
|
2021-12-05 |
2023-07-01 |
Yeda Res & Dev |
Genetically modified phages and their use
|