BE904830A - Nouvelle composition d'activateur tissulaire du plasminogene. - Google Patents
Nouvelle composition d'activateur tissulaire du plasminogene.Info
- Publication number
- BE904830A BE904830A BE0/216711A BE216711A BE904830A BE 904830 A BE904830 A BE 904830A BE 0/216711 A BE0/216711 A BE 0/216711A BE 216711 A BE216711 A BE 216711A BE 904830 A BE904830 A BE 904830A
- Authority
- BE
- Belgium
- Prior art keywords
- amino acid
- new composition
- tissue activator
- acid sequence
- plasminogen tissue
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 abstract 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 abstract 1
- 108050006955 Tissue-type plasminogen activator Proteins 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960000187 tissue plasminogen activator Drugs 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858513358A GB8513358D0 (en) | 1985-05-28 | 1985-05-28 | Formulation |
| GB858521705A GB8521705D0 (en) | 1985-08-31 | 1985-08-31 | Formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE904830A true BE904830A (fr) | 1986-11-27 |
Family
ID=26289290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/216711A BE904830A (fr) | 1985-05-28 | 1986-05-27 | Nouvelle composition d'activateur tissulaire du plasminogene. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US4929444A (OSRAM) |
| JP (1) | JPH0759517B2 (OSRAM) |
| AU (1) | AU567236B2 (OSRAM) |
| BE (1) | BE904830A (OSRAM) |
| CA (1) | CA1300008C (OSRAM) |
| CH (1) | CH665356A5 (OSRAM) |
| DE (1) | DE3617752A1 (OSRAM) |
| DK (1) | DK163173C (OSRAM) |
| ES (2) | ES8800601A1 (OSRAM) |
| FI (1) | FI85335C (OSRAM) |
| FR (1) | FR2583984B1 (OSRAM) |
| GB (1) | GB2176702B (OSRAM) |
| GR (1) | GR861366B (OSRAM) |
| HU (1) | HU195733B (OSRAM) |
| IL (1) | IL78938A (OSRAM) |
| IT (1) | IT1191926B (OSRAM) |
| LU (1) | LU86444A1 (OSRAM) |
| NL (1) | NL8601355A (OSRAM) |
| NO (1) | NO171345C (OSRAM) |
| NZ (1) | NZ216307A (OSRAM) |
| PT (1) | PT82646B (OSRAM) |
| SE (1) | SE462016B (OSRAM) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1191925B (it) * | 1985-05-28 | 1988-03-31 | Wellcome Found | Soluzione acquosa parenterale di attivatore di plasminogeno dei tessuti e procedimento di preparazione |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
| US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
| US4976959A (en) * | 1986-05-12 | 1990-12-11 | Burroughs Wellcome Co. | T-PA and SOD in limiting tissue damage |
| BE1001425A4 (fr) * | 1986-05-12 | 1989-10-31 | Wellcome Found | Utilisation de l'activateur tissulaire du plasminogene, son association avec une superoxyde-dismutase et formulation pharmaceutique contenant cette association. |
| GB8619098D0 (en) * | 1986-08-05 | 1986-09-17 | Wellcome Found | Combination |
| US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| US5342616A (en) * | 1988-06-20 | 1994-08-30 | The Wellcome Foundation Limited | Method of administering tissue plasminogen activator |
| US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
| US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
| US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
| DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
| WO1992011866A1 (en) * | 1991-01-14 | 1992-07-23 | Duke University | LAMININ SEQUENCE AS tPA ACTIVATOR |
| ES2203668T3 (es) * | 1992-06-03 | 2004-04-16 | Genentech, Inc. | Variantes de glicosilacion del activador de plasminogeno de tejido con propiedades terapeuticas mejoradas. |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| CZ117798A3 (cs) * | 1995-10-23 | 1998-08-12 | The Children's Medical Center Corporation | Antiangiogenní kompozice a způsoby léčby |
| KR100477280B1 (ko) * | 1995-12-13 | 2005-07-18 | 아보트 러보러터리즈 | 맥관형성에의한질환치료제 |
| DK0827751T3 (da) * | 1996-09-06 | 2003-03-31 | Chemo Sero Therapeut Res Inst | Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid |
| WO2003022997A2 (en) * | 2001-09-07 | 2003-03-20 | Global Biotech Inc. | Human tissue urokinase type plasminogen activator formulation |
| US20040091465A1 (en) * | 2002-06-26 | 2004-05-13 | Zachary Yim | Therapeutic antiangiogenic compositions and methods |
| JP2007525963A (ja) * | 2003-06-20 | 2007-09-13 | イルミナ インコーポレイテッド | 全ゲノム増幅および遺伝型決定のための方法および組成物 |
| US7491263B2 (en) * | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| PL1879599T3 (pl) * | 2005-04-20 | 2014-03-31 | Hutchinson Fred Cancer Res | Sposoby, kompozycje i wyroby do zwiększania przeżywalności komórek, tkanek, narządów i organizmów |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998947A (en) * | 1973-11-30 | 1976-12-21 | Pierre Fabre S.A. | Process for obtaining a plasminogen activator |
| FR2252842B1 (OSRAM) * | 1973-12-03 | 1977-11-04 | Fabre Sa Pierre | |
| DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
| US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| JPS5951220A (ja) * | 1982-08-02 | 1984-03-24 | Asahi Chem Ind Co Ltd | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
| CH660742A5 (de) * | 1982-10-29 | 1987-06-15 | Mitsui Toatsu Chemicals | Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens. |
| AU554862B2 (en) * | 1982-12-14 | 1986-09-04 | Implico B.V. | Plasminogen activator isolated by affinity chromatography |
| NZ206699A (en) * | 1982-12-30 | 1989-08-29 | Bio Response Inc | Process for the production of serum independent cell lines |
| JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
| EP0156169B1 (en) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method |
| DE3439980A1 (de) * | 1984-11-02 | 1986-05-07 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung sowie pasteurisierung von urokinase |
| EP0201153A3 (en) * | 1985-02-09 | 1987-10-07 | Beecham Group Plc | Modified enzyme and process for its preparation |
| GB8513358D0 (en) * | 1985-05-28 | 1985-07-03 | Wellcome Found | Formulation |
| ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
| JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
-
1986
- 1986-05-13 US US06/862,817 patent/US4929444A/en not_active Expired - Lifetime
- 1986-05-27 GB GB8612780A patent/GB2176702B/en not_active Expired
- 1986-05-27 DE DE19863617752 patent/DE3617752A1/de active Granted
- 1986-05-27 AU AU57964/86A patent/AU567236B2/en not_active Ceased
- 1986-05-27 IT IT48065/86A patent/IT1191926B/it active
- 1986-05-27 NZ NZ216307A patent/NZ216307A/xx unknown
- 1986-05-27 SE SE8602405A patent/SE462016B/sv not_active IP Right Cessation
- 1986-05-27 NO NO862096A patent/NO171345C/no unknown
- 1986-05-27 CH CH2126/86A patent/CH665356A5/de not_active IP Right Cessation
- 1986-05-27 CA CA000510097A patent/CA1300008C/en not_active Expired - Fee Related
- 1986-05-27 HU HU862234A patent/HU195733B/hu not_active IP Right Cessation
- 1986-05-27 NL NL8601355A patent/NL8601355A/nl not_active Application Discontinuation
- 1986-05-27 GR GR861366A patent/GR861366B/el unknown
- 1986-05-27 IL IL78938A patent/IL78938A/xx not_active IP Right Cessation
- 1986-05-27 FI FI862227A patent/FI85335C/fi not_active IP Right Cessation
- 1986-05-27 PT PT82646A patent/PT82646B/pt not_active IP Right Cessation
- 1986-05-27 ES ES555353A patent/ES8800601A1/es not_active Expired
- 1986-05-27 DK DK246786A patent/DK163173C/da not_active IP Right Cessation
- 1986-05-27 BE BE0/216711A patent/BE904830A/fr not_active IP Right Cessation
- 1986-05-27 LU LU86444A patent/LU86444A1/fr unknown
- 1986-05-27 FR FR8607552A patent/FR2583984B1/fr not_active Expired
-
1987
- 1987-02-10 ES ES557374A patent/ES8802439A1/es not_active Expired
-
1988
- 1988-07-29 US US07/226,422 patent/US4968617A/en not_active Expired - Lifetime
-
1993
- 1993-09-16 JP JP5230427A patent/JPH0759517B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE904830A (fr) | Nouvelle composition d'activateur tissulaire du plasminogene. | |
| Skidgel et al. | Human carboxypeptidase M: purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones | |
| Summaria et al. | The specific mechanism of activation of human plasminogen to plasmin | |
| Trop et al. | The specificity of proteinases from Streptomyces griseus (pronase) | |
| Dunn et al. | Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L. | |
| CA1330301C (en) | Stabilised human protein preparations | |
| AU607303B2 (en) | Composition of anticoagulants | |
| NO993709D0 (no) | Stabilisert blanding omfattende fibrinogen | |
| BE904831A (fr) | Composition d'activateur tissulaire du plasminogene. | |
| FR2426732A1 (fr) | Compositions detergentes liquides stabilisees contenant des enzymes | |
| BE1002109A3 (fr) | Composition pharmaceutique a activite analgesique. | |
| Ohno et al. | A new fluorogenic peptide substrate for vitamin K-dependent blood coagulation factor, bovine protein C | |
| FR2425245A1 (fr) | Procede pour la preparation d'une composition injectable d'urokinase | |
| Wagner et al. | Inhibitors of a rat brain enkephalin aminopeptidase | |
| Tam et al. | The importance of disulfide bridges in human endopeptidase (enkephalinase) after proteolytic cleavage | |
| CA2070882A1 (en) | A process for large-scale production of antimicrobial peptide in high purity | |
| US5387517A (en) | Thiol activated protease from stem bromelain for treating devitalized tissue | |
| Mäkinen | Inhibition by bacitracin of some hydrolytic enzymes | |
| Summaria et al. | Direct activation of human plasminogen by streptokinase | |
| EP0203696A3 (en) | Stabilized radiolabelled compounds | |
| EP0310887A3 (en) | Vasoconstrictor peptide | |
| Chin et al. | The preparation of matrix-bound proteases and their use in the hydrolysis of proteins | |
| Ichihashi et al. | Analysis of the mechanism of bleomycin-induced cutaneous fibrosis in mice | |
| US5260060A (en) | Fibrinolytic enzymes | |
| RU94031068A (ru) | Биологически активная добавка для косметических средств |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: THE WELLCOME FOUNDATION LTD Effective date: 19950531 |