ES557374A0 - Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa). - Google Patents

Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa).

Info

Publication number
ES557374A0
ES557374A0 ES557374A ES557374A ES557374A0 ES 557374 A0 ES557374 A0 ES 557374A0 ES 557374 A ES557374 A ES 557374A ES 557374 A ES557374 A ES 557374A ES 557374 A0 ES557374 A0 ES 557374A0
Authority
ES
Spain
Prior art keywords
preparing
procedure
acceptable salt
physiologically acceptable
plasminogen activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES557374A
Other languages
English (en)
Other versions
ES8802439A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES557374A0 publication Critical patent/ES557374A0/es
Publication of ES8802439A1 publication Critical patent/ES8802439A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES557374A 1985-05-28 1987-02-10 Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa). Expired ES8802439A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (2)

Publication Number Publication Date
ES557374A0 true ES557374A0 (es) 1988-06-01
ES8802439A1 ES8802439A1 (es) 1988-06-01

Family

ID=26289290

Family Applications (2)

Application Number Title Priority Date Filing Date
ES555353A Expired ES8800601A1 (es) 1985-05-28 1986-05-27 Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa)
ES557374A Expired ES8802439A1 (es) 1985-05-28 1987-02-10 Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555353A Expired ES8800601A1 (es) 1985-05-28 1986-05-27 Un procedimiento para preparar una formulacion farmaceutica liofilizada de activador de plasminogeno de tejidro (t-pa)

Country Status (22)

Country Link
US (2) US4929444A (es)
JP (1) JPH0759517B2 (es)
AU (1) AU567236B2 (es)
BE (1) BE904830A (es)
CA (1) CA1300008C (es)
CH (1) CH665356A5 (es)
DE (1) DE3617752A1 (es)
DK (1) DK163173C (es)
ES (2) ES8800601A1 (es)
FI (1) FI85335C (es)
FR (1) FR2583984B1 (es)
GB (1) GB2176702B (es)
GR (1) GR861366B (es)
HU (1) HU195733B (es)
IL (1) IL78938A (es)
IT (1) IT1191926B (es)
LU (1) LU86444A1 (es)
NL (1) NL8601355A (es)
NO (1) NO171345C (es)
NZ (1) NZ216307A (es)
PT (1) PT82646B (es)
SE (1) SE462016B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO171344C (no) * 1985-05-28 1993-03-03 Wellcome Found Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende vevsplasminogenaktivator
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
NL8701113A (nl) * 1986-05-12 1987-12-01 Wellcome Found Nieuwe farmaceutische toepassing.
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
NZ253556A (en) * 1992-06-03 1995-11-27 Genentech Inc Tissue plasminogen activator (t-pa) variants (with extended circulatory half-life and/or potency); preparation, compositions, host cells, dna sequences, and expression vehicles thereof
DE69629826T2 (de) * 1995-10-23 2004-07-01 Children's Medical Center Corp., Boston Therapeutische antiangiogenische zusammensetzungen und verfahren
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
ATE262537T1 (de) * 1995-12-13 2004-04-15 Childrens Medical Center Proliferationsinhibitor von endothellzellen und dessen verwendung
DE69719265T2 (de) * 1996-09-06 2003-12-04 Chemo Sero Therapeut Res Inst Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
US20030077682A1 (en) * 2001-09-07 2003-04-24 Hung Paul Porwen Human tissue urokinase type plasminogen activator formulation
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
US9045796B2 (en) * 2003-06-20 2015-06-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
JP2008538569A (ja) * 2005-04-20 2008-10-30 フレッド ハッチンソン キャンサー リサーチ センター 細胞、組織、臓器、および生物の生存能力を高めるための方法、組成物、および製造物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (es) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
DE3617752A1 (de) 1986-12-04
US4968617A (en) 1990-11-06
FI862227A (fi) 1986-11-29
SE8602405L (sv) 1986-11-29
CH665356A5 (de) 1988-05-13
IT8648065A0 (it) 1986-05-27
FI862227A0 (fi) 1986-05-27
PT82646A (en) 1986-06-01
GB8612780D0 (en) 1986-07-02
FR2583984B1 (fr) 1989-06-02
LU86444A1 (fr) 1986-12-05
IL78938A0 (en) 1986-09-30
HU195733B (en) 1988-07-28
AU567236B2 (en) 1987-11-12
NO171345B (no) 1992-11-23
PT82646B (pt) 1989-01-30
CA1300008C (en) 1992-05-05
HUT41638A (en) 1987-05-28
GR861366B (en) 1986-09-29
IT1191926B (it) 1988-03-31
NL8601355A (nl) 1986-12-16
DK163173B (da) 1992-02-03
DK163173C (da) 1992-06-22
ES8800601A1 (es) 1987-11-16
DK246786A (da) 1986-11-29
ES8802439A1 (es) 1988-06-01
SE8602405D0 (sv) 1986-05-27
FR2583984A1 (fr) 1987-01-02
NO171345C (no) 1993-03-03
JPH06183995A (ja) 1994-07-05
DK246786D0 (da) 1986-05-27
US4929444A (en) 1990-05-29
AU5796486A (en) 1986-12-04
GB2176702A (en) 1987-01-07
FI85335B (fi) 1991-12-31
DE3617752C2 (es) 1988-06-30
FI85335C (fi) 1992-04-10
GB2176702B (en) 1989-07-05
SE462016B (sv) 1990-04-30
NZ216307A (en) 1989-10-27
ES555353A0 (es) 1987-11-16
IL78938A (en) 1993-02-21
BE904830A (fr) 1986-11-27
JPH0759517B2 (ja) 1995-06-28
NO862096L (no) 1986-12-01

Similar Documents

Publication Publication Date Title
ES557374A0 (es) Un procedimiento para preparar una sal fisiologicamente aceptable de activador de plasminogeno de tejido (t-pa).
ES555352A0 (es) Un procedimiento para preparar una solucion parenteral de activador de plasminogeno de tejido (t-pa)
ES551770A0 (es) Un procedimiento para preparar activador de plasminogeno de tipo tejido modificado.
ES553651A0 (es) Un procedimiento para preparar un activante de plasminogeno.
ES555289A0 (es) Procedimiento para preparar una composicion efervescente de rapida disolucion de un agente terapeutico
AU6806487A (en) Tissue plasminogen activator
MX7663E (es) Un procedimiento para preparar un derivado de una enzima fibrinolitica
EP0238551A4 (en) METHODS OF RECOVERING A TISSUE PLASMINOGEN ACTIVATOR.
AU6180486A (en) Novel tissue plasminogen activator derivatives
ES554742A0 (es) Un procedimiento para preparar un derivado de 2,3-dihidro-1h-indeno y una sal del mismo
DK163639C (da) Synergistisk farmaceutisk blanding af vaevsplasminogenaktivator og et prostaglandin, farmaceutisk praeparat indeholdende blandingen samt anvendelse af blandingen til fremstilling af et laegemiddel mod blodpropper
AU3838189A (en) Tissue plasminogen activator analogues having improved activity
EP0208486A3 (en) Process for producing tissue plasminogen activator
DK369686D0 (da) Fremgangsmaade til oprensning af vaevsplasminogenaktivator
NZ219920A (en) Purification of t.p.a. (tissue plasminogen activator)
ZA863956B (en) Pharmaceutical formulations containing tissue plasminogen activator
NL189334C (nl) Therapeutisch preparaat dat catecholderivaten bevat.
EP0225177A3 (en) Dna sequence coding for human tissue plasminogen activator
IL78450A0 (en) Agent containing tissue plasminogen activator(t-pa)
ZA884012B (en) Tissue plasminogen activator analogs having modified growth factor domains
AU7090787A (en) Tissue plasminogen activator
GB8815245D0 (en) New tissue plasminogen activator
KR0135314B1 (en) Tissue plasminogen activator analogs having modified growth
EP0358274A3 (en) Method for purifying tissue plasminogen activator
AU608232C (en) Modified tissue plasminogen activator

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612