PT82646B - Processo para a preparacao de composicoes farmaceuticas liofilizadas contendo um activador de plasminogeneo de tecidos - Google Patents

Processo para a preparacao de composicoes farmaceuticas liofilizadas contendo um activador de plasminogeneo de tecidos

Info

Publication number
PT82646B
PT82646B PT82646A PT8264686A PT82646B PT 82646 B PT82646 B PT 82646B PT 82646 A PT82646 A PT 82646A PT 8264686 A PT8264686 A PT 8264686A PT 82646 B PT82646 B PT 82646B
Authority
PT
Portugal
Prior art keywords
plasticizer
activator
preparation
pharmaceutical compositions
woven fabrics
Prior art date
Application number
PT82646A
Other languages
English (en)
Other versions
PT82646A (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of PT82646A publication Critical patent/PT82646A/pt
Publication of PT82646B publication Critical patent/PT82646B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
PT82646A 1985-05-28 1986-05-27 Processo para a preparacao de composicoes farmaceuticas liofilizadas contendo um activador de plasminogeneo de tecidos PT82646B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (2)

Publication Number Publication Date
PT82646A PT82646A (en) 1986-06-01
PT82646B true PT82646B (pt) 1989-01-30

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
PT82646A PT82646B (pt) 1985-05-28 1986-05-27 Processo para a preparacao de composicoes farmaceuticas liofilizadas contendo um activador de plasminogeneo de tecidos

Country Status (22)

Country Link
US (2) US4929444A (pt)
JP (1) JPH0759517B2 (pt)
AU (1) AU567236B2 (pt)
BE (1) BE904830A (pt)
CA (1) CA1300008C (pt)
CH (1) CH665356A5 (pt)
DE (1) DE3617752A1 (pt)
DK (1) DK163173C (pt)
ES (2) ES8800601A1 (pt)
FI (1) FI85335C (pt)
FR (1) FR2583984B1 (pt)
GB (1) GB2176702B (pt)
GR (1) GR861366B (pt)
HU (1) HU195733B (pt)
IL (1) IL78938A (pt)
IT (1) IT1191926B (pt)
LU (1) LU86444A1 (pt)
NL (1) NL8601355A (pt)
NO (1) NO171345C (pt)
NZ (1) NZ216307A (pt)
PT (1) PT82646B (pt)
SE (1) SE462016B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR861365B (en) * 1985-05-28 1986-09-29 Wellcome Found Novel formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
NL8701113A (nl) * 1986-05-12 1987-12-01 Wellcome Found Nieuwe farmaceutische toepassing.
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
DK0643772T3 (da) * 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
CN1202932A (zh) * 1995-10-23 1998-12-23 儿童医学中心公司 治疗用抗血管生成的组合物和方法
WO1997023500A1 (en) * 1995-12-13 1997-07-03 The Children's Medical Center Corporation Endothelial cell proliferation inhibitor and method of use
DK0827751T3 (da) * 1996-09-06 2003-03-31 Chemo Sero Therapeut Res Inst Medicinsk præparat indeholdende vævsplasminogenaktivator og nicotinamid
WO2003022997A2 (en) * 2001-09-07 2003-03-20 Global Biotech Inc. Human tissue urokinase type plasminogen activator formulation
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
US9045796B2 (en) * 2003-06-20 2015-06-02 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
US8822535B2 (en) * 2005-04-20 2014-09-02 Fred Hutchinson Cancer Research Center Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (pt) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
NL191755C (nl) * 1982-10-29 1996-07-02 Mitsui Toatsu Chemicals Plasminogeenactivator en trombolytisch middel.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
GR861366B (en) 1986-09-29
CA1300008C (en) 1992-05-05
DK163173C (da) 1992-06-22
IT1191926B (it) 1988-03-31
HUT41638A (en) 1987-05-28
BE904830A (fr) 1986-11-27
FI85335B (fi) 1991-12-31
NO171345C (no) 1993-03-03
DK246786A (da) 1986-11-29
PT82646A (en) 1986-06-01
ES555353A0 (es) 1987-11-16
ES8800601A1 (es) 1987-11-16
DK246786D0 (da) 1986-05-27
IT8648065A0 (it) 1986-05-27
FI862227A (fi) 1986-11-29
FR2583984A1 (fr) 1987-01-02
SE8602405L (sv) 1986-11-29
US4929444A (en) 1990-05-29
US4968617A (en) 1990-11-06
AU567236B2 (en) 1987-11-12
JPH0759517B2 (ja) 1995-06-28
FR2583984B1 (fr) 1989-06-02
GB2176702B (en) 1989-07-05
FI862227A0 (fi) 1986-05-27
DE3617752A1 (de) 1986-12-04
AU5796486A (en) 1986-12-04
ES557374A0 (es) 1988-06-01
ES8802439A1 (es) 1988-06-01
NO862096L (no) 1986-12-01
IL78938A0 (en) 1986-09-30
GB8612780D0 (en) 1986-07-02
NO171345B (no) 1992-11-23
HU195733B (en) 1988-07-28
FI85335C (fi) 1992-04-10
GB2176702A (en) 1987-01-07
NL8601355A (nl) 1986-12-16
NZ216307A (en) 1989-10-27
SE8602405D0 (sv) 1986-05-27
JPH06183995A (ja) 1994-07-05
CH665356A5 (de) 1988-05-13
IL78938A (en) 1993-02-21
SE462016B (sv) 1990-04-30
DK163173B (da) 1992-02-03
DE3617752C2 (pt) 1988-06-30
LU86444A1 (fr) 1986-12-05

Similar Documents

Publication Publication Date Title
PT82646B (pt) Processo para a preparacao de composicoes farmaceuticas liofilizadas contendo um activador de plasminogeneo de tecidos
PT91731A (pt) Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas
PT88538A (pt) Processo para a preparacao de composicoes liofilizadas estaveis contendo factores de crescimento
BR8702527A (pt) Processo para a preparacao de uma triazol-sulfonamida
BR8805820A (pt) Processo para a preparacao de uma composicao polimerica
PT83756B (pt) Processo para a preparacao de composicoes farmaceuticas com libertacao controlada
PT90523A (pt) Processo para a preparacao de adsorvatos de ranitidina
PT82989B (pt) Processo para a preparacao de antibioticos beta-lactamicos
PT84477B (pt) Processo para a preparacao de uma composicao solida explosiva
PT82805B (pt) Processo para a preparacao de uma composicao de gasolina
PT83684B (pt) Processo para a preparacao de acidos heterociclil-oxoftalazinil-aceticos
PT83722B (pt) Processo para a preparacao de uma composicao detergente liquida contendo parafino-sulfonato
BR8705812A (pt) Po detergente,processo para a preparacao de um po detergente e composicao detergente granular
PT92120A (pt) Processo para a preparacao de composicoes oftalmologicas contendo ciclosporina
PT84570B (pt) Processo para a preparacao de clorato de sodio
BR8707028A (pt) Processo para a preparacao de mercaptometilfenois
PT91954A (pt) Processo para a preparacao de uma composicao aquosa de revestimento para proteccao temporaria
PT90051A (pt) Processo para a preparacao de composicoes contendo poliesteres hidrofilicos modificados
BR8807191A (pt) Maquina para aplicacao de tira alongada de material a um substrato em movimento
PT90630A (pt) Processo para a preparacao de composicoes de psilio facilmente dispersiveis
BR8702278A (pt) Processo para a preparacao de um composto e composicao
PT84072B (pt) Processo para a preparacao de esteroides aminoglicosidicos
BR8702112A (pt) Processo para a preparacao de um derivado de pirazol pirimidina
PT90435A (pt) Processo aperfeicoado para a preparacao de uma cetimina
BR8702111A (pt) Processo para a preparacao de uma sulfonamida de tiazoltriazol

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960131