FR2425245A1 - Procede pour la preparation d'une composition injectable d'urokinase - Google Patents

Procede pour la preparation d'une composition injectable d'urokinase

Info

Publication number
FR2425245A1
FR2425245A1 FR7911841A FR7911841A FR2425245A1 FR 2425245 A1 FR2425245 A1 FR 2425245A1 FR 7911841 A FR7911841 A FR 7911841A FR 7911841 A FR7911841 A FR 7911841A FR 2425245 A1 FR2425245 A1 FR 2425245A1
Authority
FR
France
Prior art keywords
urokinase
preparation
injectable composition
lyophilizing
lyophilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7911841A
Other languages
English (en)
Other versions
FR2425245B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2425245A1 publication Critical patent/FR2425245A1/fr
Application granted granted Critical
Publication of FR2425245B1 publication Critical patent/FR2425245B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

ON PREPARE UNE COMPOSITION INJECTABLE D'UROKINASE STABLE PAR LA LYOPHILISATION DE L'UROKINASE. LE PROCEDE CONSISTE A LYOPHILISER UNE SOLUTION AQUEUSE CONTENANT DE L'UROKINASE, DE L'ALBUMINE DE SERUM HUMAIN ET UN OU PLUSIEURS COMPOSES AMINOACIDES CHOISIS PARMI LES AMINOACIDES POLAIRES ET LEURS SELS. L'UROKINASE EST LARGEMENT UTILISEE EN TANT QU'AGENT FIBRINOLYTIQUE DANS LE TRAITEMENT DE MALADIES THROMBOTIQUES; LA PREPARATION DE L'INVENTION CONTENANT DE L'ACIDE GLUTAMIQUE A EGALEMENT UNE PROPRIETE CARACTERISTIQUE EXCELLENTE EN CE QUI CONCERNE SON ACTIVITE THROMBOLYTIQUE.
FR7911841A 1978-05-12 1979-05-10 Procede pour la preparation d'une composition injectable d'urokinase Granted FR2425245A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5682678A JPS54147916A (en) 1978-05-12 1978-05-12 Preparation of urokinase injection

Publications (2)

Publication Number Publication Date
FR2425245A1 true FR2425245A1 (fr) 1979-12-07
FR2425245B1 FR2425245B1 (fr) 1983-03-11

Family

ID=13038173

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7911841A Granted FR2425245A1 (fr) 1978-05-12 1979-05-10 Procede pour la preparation d'une composition injectable d'urokinase

Country Status (10)

Country Link
US (1) US4244943A (fr)
JP (1) JPS54147916A (fr)
CA (1) CA1115206A (fr)
CH (1) CH641046A5 (fr)
DE (1) DE2917899A1 (fr)
DK (1) DK147812B (fr)
FR (1) FR2425245A1 (fr)
GB (1) GB2021412B (fr)
IT (1) IT7949032A0 (fr)
SE (1) SE7904118L (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5813521A (ja) * 1981-07-16 1983-01-26 Green Cross Corp:The ミエロペルオキシダ−ゼの粉末製剤
US4350659A (en) * 1981-07-30 1982-09-21 Corning Glass Works Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives
JPS59139323A (ja) * 1983-01-28 1984-08-10 Green Cross Corp:The ウロキナ−ゼ乾燥製剤
SU1128601A1 (ru) * 1983-05-10 1985-07-15 Всесоюзный кардиологический научный центр АМН СССР Урокиназа,иммобилизированна на фибриногене
JPS6051119A (ja) * 1983-08-30 1985-03-22 Green Cross Corp:The ウロキナ−ゼ乾燥製剤
JPS61111684A (ja) * 1984-11-05 1986-05-29 Terumo Corp 精製されたウロキナ−ゼ複合体の製造方法
JPS61124383A (ja) * 1984-11-16 1986-06-12 Unitika Ltd 固定化線維素溶解活性酵素の安定化法
DE3586952T2 (de) * 1985-01-14 1993-07-22 Shiseido Co Ltd Fibrinophiler urokinase-komplex und dessen herstellung.
JPS61238732A (ja) * 1985-04-16 1986-10-24 Green Cross Corp:The ウロキナーゼ前駆体乾燥製剤
CA1336585C (fr) * 1985-04-16 1995-08-08 Kazuo Morimoto Methode de stabilisation du precurseur de l'urokinose et preparation contenant ce precurseur
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
WO1990001334A1 (fr) * 1988-08-05 1990-02-22 Codon Formules d'activateur du plasminogene a base d'aspartate
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
JPH02268681A (ja) * 1989-04-07 1990-11-02 Green Cross Corp:The ウロキナーゼ前駆体の安定化方法及び乾燥製剤
DE69025934T2 (de) * 1989-05-17 1996-09-19 Res Corp Technologies Inc Verfahren und zusammensetzung zur thrombosebehandlung beim säugetier
CA2020148C (fr) * 1989-06-30 1995-07-11 Robert Angelo Mercuri Graphite pur et souple, ultramince
EP2236617A1 (fr) 2009-03-31 2010-10-06 Leukocare Ag Procédés de stérilisation de terminal de compositions biofonctionnelles
BR112012027361A2 (pt) 2010-04-27 2021-04-27 Scil Technology Gmbh formulação mia/cd-rap estável.
CN104906054B (zh) * 2015-06-15 2017-08-25 武汉人福药业有限责任公司 一种尿激酶冻干剂的制备方法
CN111450052A (zh) * 2020-04-22 2020-07-28 南京南大药业有限责任公司 一种尿激酶注射液制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665076A (fr) * 1963-12-23 1965-12-08
FR2209776A1 (fr) * 1972-12-07 1974-07-05 Ajinomoto Kk

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665076A (fr) * 1963-12-23 1965-12-08
FR2209776A1 (fr) * 1972-12-07 1974-07-05 Ajinomoto Kk

Also Published As

Publication number Publication date
CA1115206A (fr) 1981-12-29
SE7904118L (sv) 1979-11-13
GB2021412B (en) 1982-08-25
JPS54147916A (en) 1979-11-19
DK147812B (da) 1984-12-17
CH641046A5 (de) 1984-02-15
GB2021412A (en) 1979-12-05
IT7949032A0 (it) 1979-05-11
US4244943A (en) 1981-01-13
DE2917899A1 (de) 1979-11-22
FR2425245B1 (fr) 1983-03-11
DK195079A (da) 1979-11-13

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