NO178687C - Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater - Google Patents

Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater

Info

Publication number
NO178687C
NO178687C NO883926A NO883926A NO178687C NO 178687 C NO178687 C NO 178687C NO 883926 A NO883926 A NO 883926A NO 883926 A NO883926 A NO 883926A NO 178687 C NO178687 C NO 178687C
Authority
NO
Norway
Prior art keywords
storage
compatible
preparation
stable
preparations
Prior art date
Application number
NO883926A
Other languages
English (en)
Other versions
NO883926D0 (no
NO883926L (no
NO178687B (no
Inventor
Heinrich Woog
Werner Gruber
Hans-Jorg Markl
Fritz Demmer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO883926D0 publication Critical patent/NO883926D0/no
Publication of NO883926L publication Critical patent/NO883926L/no
Publication of NO178687B publication Critical patent/NO178687B/no
Publication of NO178687C publication Critical patent/NO178687C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
NO883926A 1987-09-05 1988-09-02 Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater NO178687C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873729863 DE3729863A1 (de) 1987-09-05 1987-09-05 Stabilisierte erythropoietin-lyophilisate

Publications (4)

Publication Number Publication Date
NO883926D0 NO883926D0 (no) 1988-09-02
NO883926L NO883926L (no) 1989-03-06
NO178687B NO178687B (no) 1996-02-05
NO178687C true NO178687C (no) 1996-05-15

Family

ID=6335375

Family Applications (1)

Application Number Title Priority Date Filing Date
NO883926A NO178687C (no) 1987-09-05 1988-09-02 Fremgangsmåte for fremstilling av forenlige, lagringsstabile erythropoietinpreparater

Country Status (29)

Country Link
US (1) US4992419A (no)
EP (1) EP0306824B1 (no)
JP (1) JPH0780782B2 (no)
KR (1) KR960009929B1 (no)
CN (1) CN1027224C (no)
AT (1) ATE77556T1 (no)
AU (1) AU610636B2 (no)
CA (1) CA1330301C (no)
CS (1) CS274681B2 (no)
DD (1) DD273004A5 (no)
DE (2) DE3729863A1 (no)
DK (1) DK174811B1 (no)
ES (1) ES2051806T3 (no)
FI (1) FI93517C (no)
GR (1) GR3005454T3 (no)
HK (1) HK89495A (no)
HU (1) HU202761B (no)
IE (1) IE60310B1 (no)
IL (1) IL87628A (no)
LV (1) LV10178B (no)
MX (1) MX12880A (no)
NO (1) NO178687C (no)
NZ (1) NZ225975A (no)
PH (1) PH25618A (no)
PL (1) PL157944B1 (no)
PT (1) PT88417B (no)
RU (2) RU2043118C1 (no)
UA (2) UA26123A (no)
ZA (1) ZA886528B (no)

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DE4014654A1 (de) * 1990-05-08 1991-11-14 Behringwerke Ag Galenische waessrige formulierungen von erythropoietin und ihre verwendung
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DE4126983A1 (de) 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh Verfahren zur herstellung von humanprotein-enthaltenden, konservierten arzneimitteln fuer infusions- oder injektionszwecke
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US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US20030035845A1 (en) * 1992-06-11 2003-02-20 Zale Stephen E. Composition for sustained release of non-aggregated erythropoietin
US5661125A (en) * 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
EP0582933A1 (de) * 1992-08-11 1994-02-16 F. Hoffmann-La Roche Ag Therapeutisches System zur parenteralen Verabreichung von hämatopoetischen Wachstumsfaktoren
DE4242919A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF
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IL116085A (en) * 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
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DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
US20030138402A1 (en) * 1995-12-25 2003-07-24 Otsuka Pharmaceutical Co., Ltd. Dry compositions
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
TW518219B (en) * 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
US20030190307A1 (en) * 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
CN1222315C (zh) * 1996-12-24 2005-10-12 拜奥根有限公司 稳定的液体干扰素制剂
DE19716154A1 (de) * 1997-04-18 1998-10-22 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsform für Peptide, Proteine und Nukleinsäuren
PT986644E (pt) * 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
US6548296B1 (en) * 1997-07-23 2003-04-15 Roche Diagnostics Gmbh Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof
AR019025A1 (es) 1998-04-09 2001-12-26 Roche Diagnostics Gmbh Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado
EP0965349A1 (de) * 1998-06-18 1999-12-22 Roche Diagnostics GmbH Verwendung von Erythropoietin zur Behandlung von Hämochromatosen
JP2000247903A (ja) 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
MXPA01010208A (es) 1999-04-09 2003-07-21 Johnson & Johnson Composiciones farmaceuticas de eritropoyetina.
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7253142B1 (en) * 1999-09-08 2007-08-07 Chugai Seiyaku Kabushiki Kaisha Protein solution preparation and method of stabilizing the same
AU2005225151B2 (en) * 2000-05-15 2008-05-29 F. Hoffmann-La Roche Ag New pharmaceutical composition
CN1309416C (zh) * 2000-05-15 2007-04-11 霍夫曼-拉罗奇有限公司 新的药物组合物
JP5485489B2 (ja) * 2000-08-11 2014-05-07 中外製薬株式会社 抗体含有安定化製剤
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
DE10149030A1 (de) 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
US7425618B2 (en) * 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US7132100B2 (en) * 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
SI21257A (sl) * 2002-07-17 2004-02-29 LEK farmacevtska dru�ba d.d. Stabilni farmacevtski pripravek, ki vsebuje eritropoietin
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
US20040208869A1 (en) * 2003-01-30 2004-10-21 Medimmune, Inc. Uses of anti-integrin alphanubeta3 antibody formulations
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HUT41632A (en) * 1985-03-06 1987-05-28 Survival Technology Process for preparing agents for the enhancement of protein absorption

Also Published As

Publication number Publication date
IL87628A (en) 1993-07-08
NO883926D0 (no) 1988-09-02
CA1330301C (en) 1994-06-21
NO883926L (no) 1989-03-06
PL157944B1 (en) 1992-07-31
CS590188A2 (en) 1990-12-13
HUT47863A (en) 1989-04-28
IL87628A0 (en) 1989-01-31
PT88417A (pt) 1989-07-31
GR3005454T3 (no) 1993-05-24
EP0306824B1 (de) 1992-06-24
RU2043118C1 (ru) 1995-09-10
PT88417B (pt) 1992-10-30
JPS6471818A (en) 1989-03-16
NZ225975A (en) 1991-07-26
LV10178B (en) 1995-04-20
US4992419A (en) 1991-02-12
JPH0780782B2 (ja) 1995-08-30
FI93517B (fi) 1995-01-13
DD273004A5 (de) 1989-11-01
ATE77556T1 (de) 1992-07-15
DE3872334D1 (de) 1992-07-30
EP0306824A2 (de) 1989-03-15
IE60310B1 (en) 1994-06-29
RU2100032C1 (ru) 1997-12-27
HU202761B (en) 1991-04-29
HK89495A (en) 1995-06-16
DK174811B1 (da) 2003-12-01
NO178687B (no) 1996-02-05
AU2173988A (en) 1989-04-27
EP0306824A3 (en) 1990-01-31
FI884051A0 (fi) 1988-09-02
DE3729863A1 (de) 1989-03-16
AU610636B2 (en) 1991-05-23
KR960009929B1 (ko) 1996-07-25
IE882671L (en) 1989-03-05
FI884051A (fi) 1989-03-06
UA26123A (uk) 1999-06-07
PH25618A (en) 1991-08-08
KR890004718A (ko) 1989-05-09
ES2051806T3 (es) 1994-07-01
CN1031801A (zh) 1989-03-22
DK483188D0 (da) 1988-08-30
UA26855C2 (uk) 1999-12-29
MX12880A (es) 1993-12-01
PL274485A1 (en) 1989-04-17
ZA886528B (en) 1989-05-30
LV10178A (lv) 1994-10-20
DK483188A (da) 1989-03-06
FI93517C (fi) 1995-04-25
CN1027224C (zh) 1995-01-04
CS274681B2 (en) 1991-09-15

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