BE903128A - Derives de benzimidazole procede pour leur preparation et agents anti-ulceres en contenant - Google Patents
Derives de benzimidazole procede pour leur preparation et agents anti-ulceres en contenantInfo
- Publication number
- BE903128A BE903128A BE0/215506A BE215506A BE903128A BE 903128 A BE903128 A BE 903128A BE 0/215506 A BE0/215506 A BE 0/215506A BE 215506 A BE215506 A BE 215506A BE 903128 A BE903128 A BE 903128A
- Authority
- BE
- Belgium
- Prior art keywords
- group
- preparation
- agents containing
- benzimidazole derivatives
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59182400A JPS6160660A (ja) | 1984-08-31 | 1984-08-31 | ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
JP60061194A JPH068283B2 (ja) | 1985-03-26 | 1985-03-26 | ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
JP60061195A JPH0764826B2 (ja) | 1985-03-26 | 1985-03-26 | ベンズイミダゾール誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE903128A true BE903128A (fr) | 1985-12-16 |
Family
ID=27297422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/215506A BE903128A (fr) | 1984-08-31 | 1985-08-27 | Derives de benzimidazole procede pour leur preparation et agents anti-ulceres en contenant |
Country Status (14)
Country | Link |
---|---|
KR (1) | KR920004936B1 (es) |
AR (1) | AR242195A1 (es) |
AU (3) | AU4640985A (es) |
BE (1) | BE903128A (es) |
BR (1) | BR8504252A (es) |
CH (1) | CH665417A5 (es) |
DE (1) | DE3531487C2 (es) |
ES (1) | ES8703142A1 (es) |
FR (1) | FR2569691B1 (es) |
GB (1) | GB2163747B (es) |
IT (1) | IT1189601B (es) |
MX (1) | MX159807A (es) |
NL (1) | NL8502384A (es) |
SE (1) | SE500669C2 (es) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8417194D0 (en) * | 1984-07-05 | 1984-08-08 | Boots Co Plc | Therapeutic agents |
GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
DE3585252D1 (de) | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
AU5768886A (en) * | 1985-05-24 | 1986-11-27 | G.D. Searle & Co. | 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines |
US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
US4824856A (en) * | 1985-08-14 | 1989-04-25 | Nippon Chemiphar Co., Ltd. | Method of protecting gastrointestinal tract |
WO1987001114A2 (en) * | 1985-08-21 | 1987-02-26 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New amines, process for their manufacture, their use and medicines containing them |
AR243167A1 (es) | 1985-08-24 | 1993-07-30 | Hoechst Ag | Procedimiento para la preparacion de toluidinas sustituidas. |
AU619444B2 (en) * | 1986-06-02 | 1992-01-30 | Nippon Chemiphar Co. Ltd. | 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives |
EP0251536A1 (en) * | 1986-06-24 | 1988-01-07 | FISONS plc | Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors |
DE3639926A1 (de) * | 1986-11-22 | 1988-06-01 | Hoechst Ag | Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
JP2614756B2 (ja) * | 1988-08-10 | 1997-05-28 | 日本ケミファ株式会社 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
JPH06298611A (ja) * | 1993-04-16 | 1994-10-25 | Nippon Chemiphar Co Ltd | 抗菌剤 |
SE9301489D0 (sv) | 1993-04-30 | 1993-04-30 | Ab Astra | Veterinary composition |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
HRP960232A2 (en) * | 1995-07-03 | 1998-02-28 | Astra Ab | A process for the optical purification of compounds |
NZ318501A (en) * | 1995-09-21 | 1999-06-29 | Pharma Pass Llc | Novel composition containing an acid-labile omeprazole and process for its preparation |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
US6380222B2 (en) | 1996-10-11 | 2002-04-30 | Astrazeneca Ab | Use of an H+, K+-atpase inhibitor in the treatment of nasal polyps |
PT1003554E (pt) | 1997-07-25 | 2005-03-31 | Altana Pharma Ag | Inibidor da bomba de protoes em combinacao terapeutica com substancias antibacterianas |
SE9704869D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulaton II |
SE9704870D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulation I |
WO2000009092A1 (en) | 1998-08-12 | 2000-02-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles |
AU1054899A (en) * | 1998-11-06 | 2000-05-29 | Dong-A Pharmaceutical Co., Ltd. | Method of preparing sulfide derivatives |
TWI243672B (en) | 1999-06-01 | 2005-11-21 | Astrazeneca Ab | New use of compounds as antibacterial agents |
PT1187601E (pt) | 1999-06-07 | 2005-11-30 | Altana Pharma Ag | Nova forma de preparacao e a administracao compreendendo um inibidor da bomba de protoes instavel em meio acido |
SE9903831D0 (sv) | 1999-10-22 | 1999-10-22 | Astra Ab | Formulation of substituted benzimidazoles |
SE0000774D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
SE0102993D0 (sv) | 2001-09-07 | 2001-09-07 | Astrazeneca Ab | New self emulsifying drug delivery system |
US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
KR20050005437A (ko) | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
MXPA04009968A (es) | 2002-04-09 | 2004-12-13 | Flamel Tech Sa | Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s). |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
EP2112920B1 (en) | 2003-06-26 | 2018-07-25 | Intellipharmaceutics Corp. | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
WO2005072079A2 (en) | 2003-09-26 | 2005-08-11 | Alza Coporation | Drug coating providing high drug loading and methods for providing the same |
US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
CA2648280C (en) | 2006-04-03 | 2014-03-11 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
PL2046334T3 (pl) | 2006-07-25 | 2015-02-27 | Vecta Ltd | Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI |
RU2491075C2 (ru) | 2006-12-22 | 2013-08-27 | Айронвуд Фармасьютикалз, Инк. | Способы и композиции для лечения расстройств пищевода |
KR20110079641A (ko) | 2008-09-09 | 2011-07-07 | 아스트라제네카 아베 | 제약 조성물을 이를 필요로 하는 환자에게 전달하는 방법 |
AU2010263304A1 (en) | 2009-06-25 | 2012-02-02 | Astrazeneca Ab | Method for treating a patient at risk for developing an NSAID-associated ulcer |
WO2011080500A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
WO2011080502A2 (en) | 2009-12-29 | 2011-07-07 | Orexo Ab | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
US20120294937A1 (en) | 2009-12-29 | 2012-11-22 | Novartis Ag | New pharmaceutical dosage form for the treatment of gastric acid-related disorders |
WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
EP2601947A1 (en) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Fixed-dose combination for treatment of helicobacter pylori associated diseases |
EP2797600A4 (en) | 2011-12-28 | 2015-09-16 | Pozen Inc | IMPROVED COMPOSITIONS AND METHODS OF DISTRIBUTING OMEPRAZOLE AND ACETYL SALICYLIC ACID |
CA2898362C (en) | 2013-01-15 | 2020-09-01 | Ironwood Pharmaceuticals, Inc. | Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant |
EP2801565B1 (en) * | 2013-05-06 | 2015-07-22 | King Saud University | Compounds for use as anti-ulcer agent and/or anti-Helicobacter pylori agent and pharmaceutical compositions thereof |
US20180015118A1 (en) | 2015-02-03 | 2018-01-18 | Ironwood Pharmaceuticals, Inc. | Methods of treating upper gastrointestinal disorders in ppi refractory gerd |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
DE3585252D1 (de) * | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
-
1985
- 1985-08-19 AU AU46409/85A patent/AU4640985A/en not_active Abandoned
- 1985-08-27 ES ES546445A patent/ES8703142A1/es not_active Expired
- 1985-08-27 BE BE0/215506A patent/BE903128A/fr not_active IP Right Cessation
- 1985-08-29 GB GB08521493A patent/GB2163747B/en not_active Expired
- 1985-08-29 CH CH3709/85A patent/CH665417A5/fr not_active IP Right Cessation
- 1985-08-30 KR KR1019850006307A patent/KR920004936B1/ko not_active IP Right Cessation
- 1985-08-30 FR FR858512961A patent/FR2569691B1/fr not_active Expired
- 1985-08-30 BR BR8504252A patent/BR8504252A/pt unknown
- 1985-08-30 DE DE3531487A patent/DE3531487C2/de not_active Expired - Fee Related
- 1985-08-30 SE SE8504048A patent/SE500669C2/sv unknown
- 1985-08-30 IT IT67743/85A patent/IT1189601B/it active
- 1985-08-30 MX MX206462A patent/MX159807A/es unknown
- 1985-08-30 AR AR85301474A patent/AR242195A1/es active
- 1985-08-30 NL NL8502384A patent/NL8502384A/nl not_active Application Discontinuation
-
1989
- 1989-09-11 AU AU41271/89A patent/AU4127189A/en not_active Abandoned
-
1992
- 1992-11-27 AU AU29750/92A patent/AU647978B2/en not_active Ceased
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
Also Published As
Publication number | Publication date |
---|---|
IT8567743A0 (it) | 1985-08-30 |
NL8502384A (nl) | 1986-03-17 |
IT1189601B (it) | 1988-02-04 |
ES546445A0 (es) | 1986-11-16 |
BR8504252A (pt) | 1986-06-17 |
KR860001793A (ko) | 1986-03-22 |
AU647978B2 (en) | 1994-03-31 |
FR2569691B1 (fr) | 1989-08-04 |
AR242195A1 (es) | 1993-03-31 |
GB8521493D0 (en) | 1985-10-02 |
DE3531487A1 (de) | 1986-03-13 |
CH665417A5 (fr) | 1988-05-13 |
AU4127189A (en) | 1989-12-21 |
SE8504048D0 (sv) | 1985-08-30 |
GB2163747A (en) | 1986-03-05 |
SE8504048L (sv) | 1986-03-01 |
FR2569691A1 (fr) | 1986-03-07 |
ES8703142A1 (es) | 1986-11-16 |
MX159807A (es) | 1989-08-31 |
KR920004936B1 (ko) | 1992-06-22 |
GB2163747B (en) | 1989-02-08 |
AU4640985A (en) | 1986-03-06 |
SE500669C2 (sv) | 1994-08-08 |
AU2975092A (en) | 1993-01-28 |
DE3531487C2 (de) | 1995-08-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: NIPPON CHEMIPHAR CO. LTD Effective date: 20000831 |