FR2569691B1 - Derives de benzimidazole, procede pour les preparer et agents anti-ulcereux les contenant - Google Patents

Derives de benzimidazole, procede pour les preparer et agents anti-ulcereux les contenant

Info

Publication number
FR2569691B1
FR2569691B1 FR858512961A FR8512961A FR2569691B1 FR 2569691 B1 FR2569691 B1 FR 2569691B1 FR 858512961 A FR858512961 A FR 858512961A FR 8512961 A FR8512961 A FR 8512961A FR 2569691 B1 FR2569691 B1 FR 2569691B1
Authority
FR
France
Prior art keywords
preparation
agents containing
benzimidazole derivatives
ulcer agents
ulcer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR858512961A
Other languages
English (en)
Other versions
FR2569691A1 (fr
Inventor
Susumu Okabe
Masaru Satoh
Tomio Yamakawa
Yutaka Nomura
Masatoshi Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59182400A external-priority patent/JPS6160660A/ja
Priority claimed from JP60061194A external-priority patent/JPH068283B2/ja
Priority claimed from JP60061195A external-priority patent/JPH0764826B2/ja
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of FR2569691A1 publication Critical patent/FR2569691A1/fr
Application granted granted Critical
Publication of FR2569691B1 publication Critical patent/FR2569691B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR858512961A 1984-08-31 1985-08-30 Derives de benzimidazole, procede pour les preparer et agents anti-ulcereux les contenant Expired FR2569691B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59182400A JPS6160660A (ja) 1984-08-31 1984-08-31 ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JP60061194A JPH068283B2 (ja) 1985-03-26 1985-03-26 ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JP60061195A JPH0764826B2 (ja) 1985-03-26 1985-03-26 ベンズイミダゾール誘導体

Publications (2)

Publication Number Publication Date
FR2569691A1 FR2569691A1 (fr) 1986-03-07
FR2569691B1 true FR2569691B1 (fr) 1989-08-04

Family

ID=27297422

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858512961A Expired FR2569691B1 (fr) 1984-08-31 1985-08-30 Derives de benzimidazole, procede pour les preparer et agents anti-ulcereux les contenant

Country Status (14)

Country Link
KR (1) KR920004936B1 (fr)
AR (1) AR242195A1 (fr)
AU (3) AU4640985A (fr)
BE (1) BE903128A (fr)
BR (1) BR8504252A (fr)
CH (1) CH665417A5 (fr)
DE (1) DE3531487C2 (fr)
ES (1) ES8703142A1 (fr)
FR (1) FR2569691B1 (fr)
GB (1) GB2163747B (fr)
IT (1) IT1189601B (fr)
MX (1) MX159807A (fr)
NL (1) NL8502384A (fr)
SE (1) SE500669C2 (fr)

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US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
EP0204215B1 (fr) * 1985-05-24 1993-08-11 G.D. Searle & Co. [(1H-benzimidazol-yl-2-sulfonyl)méthyl]-2-benzèneamines
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
WO1987001114A2 (fr) * 1985-08-21 1987-02-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouvelles amines, leur procede de fabrication, leur utilisation, et medicaments les contenant
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
EP0251536A1 (fr) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, leur préparation, formulation et utilisation comme inhibiteurs de sécrétion d'acide gastrique
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JPH06298611A (ja) * 1993-04-16 1994-10-25 Nippon Chemiphar Co Ltd 抗菌剤
SE9301489D0 (sv) 1993-04-30 1993-04-30 Ab Astra Veterinary composition
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
PL186605B1 (pl) * 1995-09-21 2004-01-30 Pharma Pass Llc Tabletka lub mikrotabletka zawierająca rdzeń posiadający jako kwasolabilny składnik aktywny omeprazol oraz sposób wytwarzania tabletek lub mikrotabletek zawierających rdzeń posiadający jako kwasolabilny składnik aktywny omeprazol
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6380222B2 (en) 1996-10-11 2002-04-30 Astrazeneca Ab Use of an H+, K+-atpase inhibitor in the treatment of nasal polyps
EP1003554B1 (fr) 1997-07-25 2004-11-03 ALTANA Pharma AG Inhibiteur de la pompe a protons en combinaison therapeutique avec des substances antibacteriennes
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
SE9704870D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
SI1105105T1 (sl) 1998-08-12 2006-08-31 Altana Pharma Ag Oralna dajalna oblika za piridin-2-ilmetilsulfinil-1J-benzimidazole
AU1054899A (en) * 1998-11-06 2000-05-29 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
ATE300285T1 (de) 1999-06-07 2005-08-15 Altana Pharma Ag Neue zubereitung und darreichungsform enthaltend einen säurelabilen protonenpumpeninhibitor
SE9903831D0 (sv) 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
PT1492511E (pt) 2002-04-09 2009-04-09 Flamel Tech Sa Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s)
CA2480824A1 (fr) 2002-04-09 2003-10-16 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee d'amoxicilline
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
MXPA06003450A (es) 2003-09-26 2006-08-31 Johnson & Johnson Recubrimiento de farmaco que proporciona alta carga del farmaco y metodos para proporcionar el mismo.
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
WO2007112581A1 (fr) 2006-04-03 2007-10-11 Isa Odidi Dispositif d'administration à libération commandée comprenant un enrobage organosol
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
EP2046334B1 (fr) 2006-07-25 2014-05-21 Vecta Ltd. Compositions et procédés d'inhibition de sécrétion d'acide gastrique utilisant des dérivés de petits acides dicarboxyliques combinés á un ipp
SI2124884T1 (sl) 2006-12-22 2019-09-30 Ironwood Pharmaceuticals, Inc. Pripravki, ki obsegajo sekvestrante žolčnih kislin, za zdravljenje motenj požiralnika
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080501A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
CA2860231A1 (fr) 2011-12-28 2013-07-04 Pozen Inc. Compositions et procedes d'administration d'omeprazole plus acide acetylsalicylique ameliores
WO2014113377A1 (fr) 2013-01-15 2014-07-24 Ironwood Pharmaceuticals, Inc. Forme posologique orale à libération prolongée à rétention gastrique d'un agent séquestrant d'acide biliaire
EP2801565B1 (fr) * 2013-05-06 2015-07-22 King Saud University Composés destinés à être utilisés en tant qu'agent antiulcéreux et/ou agent anti-helicobacter pylori et leurs compositions pharmaceutiques
WO2016126625A1 (fr) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Méthodes de traitement de troubles gastro-intestinaux supérieurs de gerd réfractaire à ppi

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CA1341314C (fr) * 1984-07-06 2001-11-06 David Cox Derives de benzimidazole, benzothiazole et benzoxazole

Also Published As

Publication number Publication date
FR2569691A1 (fr) 1986-03-07
CH665417A5 (fr) 1988-05-13
GB8521493D0 (en) 1985-10-02
IT8567743A0 (it) 1985-08-30
GB2163747A (en) 1986-03-05
BR8504252A (pt) 1986-06-17
SE500669C2 (sv) 1994-08-08
KR920004936B1 (ko) 1992-06-22
SE8504048L (sv) 1986-03-01
AU647978B2 (en) 1994-03-31
NL8502384A (nl) 1986-03-17
GB2163747B (en) 1989-02-08
BE903128A (fr) 1985-12-16
ES546445A0 (es) 1986-11-16
ES8703142A1 (es) 1986-11-16
AU4127189A (en) 1989-12-21
MX159807A (es) 1989-08-31
DE3531487C2 (de) 1995-08-17
AU2975092A (en) 1993-01-28
DE3531487A1 (de) 1986-03-13
IT1189601B (it) 1988-02-04
AU4640985A (en) 1986-03-06
AR242195A1 (es) 1993-03-31
KR860001793A (ko) 1986-03-22
SE8504048D0 (sv) 1985-08-30

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Legal Events

Date Code Title Description
ST Notification of lapse