IT1189601B - Derivati di benzimidazolo procedimento per la loro preparazione e agenti antiulcera che li contengono - Google Patents

Derivati di benzimidazolo procedimento per la loro preparazione e agenti antiulcera che li contengono

Info

Publication number
IT1189601B
IT1189601B IT67743/85A IT6774385A IT1189601B IT 1189601 B IT1189601 B IT 1189601B IT 67743/85 A IT67743/85 A IT 67743/85A IT 6774385 A IT6774385 A IT 6774385A IT 1189601 B IT1189601 B IT 1189601B
Authority
IT
Italy
Prior art keywords
benzyl
alkyl
sulphinyl
pref
effected
Prior art date
Application number
IT67743/85A
Other languages
English (en)
Other versions
IT8567743A0 (it
Inventor
Okabe Susumu
Satoh Masaru
Yamakawa Tomio
Nomura Yutaka
Hayashi Masatoshi
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59182400A external-priority patent/JPS6160660A/ja
Priority claimed from JP60061195A external-priority patent/JPH0764826B2/ja
Priority claimed from JP60061194A external-priority patent/JPH068283B2/ja
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Publication of IT8567743A0 publication Critical patent/IT8567743A0/it
Application granted granted Critical
Publication of IT1189601B publication Critical patent/IT1189601B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT67743/85A 1984-08-31 1985-08-30 Derivati di benzimidazolo procedimento per la loro preparazione e agenti antiulcera che li contengono IT1189601B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59182400A JPS6160660A (ja) 1984-08-31 1984-08-31 ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JP60061195A JPH0764826B2 (ja) 1985-03-26 1985-03-26 ベンズイミダゾール誘導体
JP60061194A JPH068283B2 (ja) 1985-03-26 1985-03-26 ベンズイミダゾ−ル誘導体およびその製造法ならびにこれを含有する抗潰瘍剤

Publications (2)

Publication Number Publication Date
IT8567743A0 IT8567743A0 (it) 1985-08-30
IT1189601B true IT1189601B (it) 1988-02-04

Family

ID=27297422

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67743/85A IT1189601B (it) 1984-08-31 1985-08-30 Derivati di benzimidazolo procedimento per la loro preparazione e agenti antiulcera che li contengono

Country Status (14)

Country Link
KR (1) KR920004936B1 (it)
AR (1) AR242195A1 (it)
AU (3) AU4640985A (it)
BE (1) BE903128A (it)
BR (1) BR8504252A (it)
CH (1) CH665417A5 (it)
DE (1) DE3531487C2 (it)
ES (1) ES8703142A1 (it)
FR (1) FR2569691B1 (it)
GB (1) GB2163747B (it)
IT (1) IT1189601B (it)
MX (1) MX159807A (it)
NL (1) NL8502384A (it)
SE (1) SE500669C2 (it)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
EP0174717B1 (en) 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
EP0232399A1 (de) * 1985-08-21 1987-08-19 Byk Gulden Lomberg Chemische Fabrik GmbH Neue amine, verfahren zu ihrer herstellung, ihre anwendung und sie enthaltende arzneimittel
AR243167A1 (es) 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
DE3639926A1 (de) * 1986-11-22 1988-06-01 Hoechst Ag Substituierte thienoimidazoltoluidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
JP2614756B2 (ja) * 1988-08-10 1997-05-28 日本ケミファ株式会社 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
JPH06298611A (ja) * 1993-04-16 1994-10-25 Nippon Chemiphar Co Ltd 抗菌剤
SE9301489D0 (sv) 1993-04-30 1993-04-30 Ab Astra Veterinary composition
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
ES2236628T3 (es) * 1995-09-21 2005-07-16 Pharma Pass Ii Llc Composicion farmaceutica que contiene un omeprazol labil de acido, y procedimiento para su preparacion.
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6599927B2 (en) 1996-10-11 2003-07-29 Astrazeneca Ab Use of an H+, K+-ATPase inhibitor in the treatment of Widal's Syndrome
WO1999004816A1 (en) 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Proton pump inhibitor in therapeutic combination with antibacterial substances
SE9704870D0 (sv) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
ES2262335T3 (es) 1998-08-12 2006-11-16 Altana Pharma Ag Forma de administracion oral para piridin-2-ilmetilsulfinil-1h-bencimidazoles.
WO2000027841A1 (en) * 1998-11-06 2000-05-18 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
YU86001A (sh) 1999-06-07 2004-07-15 Altana Pharma Ag. Novi preparat i oblik, u kojem se daje lek, koji sadrži aktivno jedinjenje labilno prema kiselini
SE9903831D0 (sv) * 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
JP4698950B2 (ja) 2002-04-09 2011-06-08 フラメル・テクノロジー アモキシシリンの改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
CN100553625C (zh) 2002-04-09 2009-10-28 弗拉梅技术公司 活性成分微囊的口服混悬液
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
WO2007112581A1 (en) 2006-04-03 2007-10-11 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
AU2007278986B2 (en) 2006-07-25 2010-09-16 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
NZ598728A (en) 2006-12-22 2013-09-27 Ironwood Pharmaceuticals Inc Compositions comprising bile acid sequestrants for treating esophageal disorders
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
CA2764963C (en) 2009-06-25 2016-11-01 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico
MX383752B (es) 2013-01-15 2025-03-11 Ironwood Pharmaceuticals Inc Forma de dosificación oral de liberación sostenida gastro retentiva de un secuestrante de ácido biliar.
EP2801565B1 (en) 2013-05-06 2015-07-22 King Saud University Compounds for use as anti-ulcer agent and/or anti-Helicobacter pylori agent and pharmaceutical compositions thereof
WO2016126625A1 (en) 2015-02-03 2016-08-11 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors

Also Published As

Publication number Publication date
GB8521493D0 (en) 1985-10-02
SE8504048L (sv) 1986-03-01
NL8502384A (nl) 1986-03-17
GB2163747B (en) 1989-02-08
KR860001793A (ko) 1986-03-22
AU4640985A (en) 1986-03-06
KR920004936B1 (ko) 1992-06-22
CH665417A5 (fr) 1988-05-13
BR8504252A (pt) 1986-06-17
BE903128A (fr) 1985-12-16
IT8567743A0 (it) 1985-08-30
AR242195A1 (es) 1993-03-31
DE3531487A1 (de) 1986-03-13
SE8504048D0 (sv) 1985-08-30
DE3531487C2 (de) 1995-08-17
ES546445A0 (es) 1986-11-16
ES8703142A1 (es) 1986-11-16
MX159807A (es) 1989-08-31
FR2569691B1 (fr) 1989-08-04
AU4127189A (en) 1989-12-21
GB2163747A (en) 1986-03-05
AU2975092A (en) 1993-01-28
AU647978B2 (en) 1994-03-31
FR2569691A1 (fr) 1986-03-07
SE500669C2 (sv) 1994-08-08

Similar Documents

Publication Publication Date Title
IT1189601B (it) Derivati di benzimidazolo procedimento per la loro preparazione e agenti antiulcera che li contengono
AR245718A1 (es) Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina
DK428188A (da) Fremgangsmaade til fremstilling af 2-(2-pyridylmetylsulfinyl)-benzimidazol-forbindelser
WO2002003984A3 (en) Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
DE69120581D1 (de) 1,8-Naphthyridin-2-on-Derivate
DE3772580D1 (de) Adhaesionsvermittler, verfahren zu ihrer herstellung und ihre verwendung in polyimide-mineraloxide-metall-schichtkoerpern.
EP0927711A4 (en) ADAMANT DERIVATIVES AND METHOD FOR THEIR PRODUCTION
ES8402561A1 (es) Procedimiento para preparar derivados de guanidina.
DE3686232D1 (de) Lactamderivate, deren herstellung und deren benutzung als hypotensive mittel.
DE3872317D1 (de) Verwendung eines epoxidierungs-reagenz, sowie verfahren zur herstellung von 5 alpha(10 alpha)-epoxi delta 9,11-steroiden.
ATE97894T1 (de) Pharmakologisch-aktive alkylthiobenzimidazolderivate und verfahren zu deren herstellung.
ATE82292T1 (de) Verfahren zur herstellung von 2-alpha-methyl-2beta-(1,2,3-triazol-1-yl)methylpenam-3-alphacarbons|urederivaten.
DE3750842D1 (de) Penem-Derivate, ihre Herstellung und Verwendung.
DE59102789D1 (de) Verfahren zur Herstellung von Alkyltetrahydroanthrahydrochinonlösungen und ihre Verwendung als Arbeitslösung bei der Wasserstoffperoxid-Herstellung nach dem Anthrachinonverfahren.
ATE38665T1 (de) Verfahren zur herstellung von 5-perfluoralkyl-5,6-dihydrouracyl-derivaten und verwendbare zwischenprodukte.
KR870007142A (ko) 이환 화합물의 제조방법
IE37988B1 (en) Substituted benzene-1,3-disulphonamides and process for their manufacture
IE39170L (en) Methyl 3-(2-quinoxalinylmethlene) carbazate n', n'-dioxide
DE3851783D1 (de) Verfahren zur Herstellung von 6-[D(-)-alpha-(4-Äthyl-2,3-dioxo-1-piperazin-carboxamido)-phenylacetamido]penicillansäure.
KR890009893A (ko) 술폰 유도체의 제조방법
ATE127126T1 (de) Verfahren zur herstellung von 1-alpha,3-beta,24- trihydroxy-delta-5-steroidderivaten.
ES2058542T3 (es) Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas.
DE58906619D1 (de) Neue Leukotrien-B4-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
HUT47304A (en) Process for producing pharmacologically effective, new condensed heterocyclic compounds from secologanin
KR910021360A (ko) 하이드록시카보닐 유도체 및 이의 제조방법

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990331