ES2058542T3 - Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas. - Google Patents

Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas.

Info

Publication number
ES2058542T3
ES2058542T3 ES89308479T ES89308479T ES2058542T3 ES 2058542 T3 ES2058542 T3 ES 2058542T3 ES 89308479 T ES89308479 T ES 89308479T ES 89308479 T ES89308479 T ES 89308479T ES 2058542 T3 ES2058542 T3 ES 2058542T3
Authority
ES
Spain
Prior art keywords
benzoisotiazolyl
antipsychotic
imides
piperazinyl
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308479T
Other languages
English (en)
Inventor
Gene Michael Bright
Iii John Adams Lowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2058542T3 publication Critical patent/ES2058542T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I): O UNA SAL DE ADICCION DEL ACIDO FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS EN DONDE CADA R1 Y R2 QUE PUEDEN SER LO MISMO O DIFERENTE ES HIDROGENO, METIL O ETIL; X ES -CH2- , -CH2CH2- O CH2CH2CH2-; Y ES CR3R4 EN DONDE CADA UNA DE R3 Y R4, QUE PUEDEN SER LO MISMO O DIFERENTES ES HIDROGENO O METIL.
ES89308479T 1988-09-16 1989-08-22 Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas. Expired - Lifetime ES2058542T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/003230 WO1990002552A1 (en) 1988-09-16 1988-09-16 Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides

Publications (1)

Publication Number Publication Date
ES2058542T3 true ES2058542T3 (es) 1994-11-01

Family

ID=22208913

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308479T Expired - Lifetime ES2058542T3 (es) 1988-09-16 1989-08-22 Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas.

Country Status (20)

Country Link
US (1) US5077295A (es)
EP (1) EP0364091B1 (es)
JP (1) JPH0631231B2 (es)
KR (1) KR930002568B1 (es)
AT (1) ATE92063T1 (es)
AU (1) AU607354B2 (es)
CA (1) CA1339314C (es)
DE (1) DE68907845T2 (es)
DK (1) DK175200B1 (es)
ES (1) ES2058542T3 (es)
FI (1) FI911285A7 (es)
HU (1) HUT61760A (es)
IE (1) IE61413B1 (es)
IL (1) IL91552A (es)
MY (1) MY104207A (es)
NO (1) NO911042L (es)
NZ (1) NZ230672A (es)
PT (1) PT91703B (es)
WO (1) WO1990002552A1 (es)
ZA (1) ZA897049B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235283A (en) * 1991-02-07 1993-08-10 Siemens Aktiengesellschaft Gradient coil system for a nuclear magnetic resonance tomography apparatus which reduces acoustic noise
DE69726206T2 (de) * 1996-02-13 2004-04-15 Pfizer Inc. Prodrogen von 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-on
US6084097A (en) * 1997-10-20 2000-07-04 Council Of Scientific & Industrial Research Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl] propanes
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
JPS5995267A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
JPH0310760A (ja) * 1989-06-09 1991-01-18 Nippon Spindle Mfg Co Ltd 結晶質脆性材料切断用ワイヤソー

Also Published As

Publication number Publication date
NO911042L (no) 1991-05-15
JPH0631231B2 (ja) 1994-04-27
FI911285A0 (fi) 1991-03-15
DE68907845D1 (de) 1993-09-02
IE892949L (en) 1990-03-16
DK175200B1 (da) 2004-07-05
NZ230672A (en) 1990-12-21
AU607354B2 (en) 1991-02-28
KR930002568B1 (ko) 1993-04-03
PT91703A (pt) 1990-03-30
FI911285A7 (fi) 1991-03-15
AU4150689A (en) 1990-03-22
CA1339314C (en) 1997-08-19
MY104207A (en) 1994-02-28
EP0364091B1 (en) 1993-07-28
IL91552A0 (en) 1990-04-29
IE61413B1 (en) 1994-11-02
ZA897049B (en) 1991-04-24
DE68907845T2 (de) 1993-11-11
JPH02121986A (ja) 1990-05-09
PT91703B (pt) 1995-07-18
ATE92063T1 (de) 1993-08-15
WO1990002552A1 (en) 1990-03-22
HUT61760A (en) 1993-03-01
EP0364091A1 (en) 1990-04-18
DK456389D0 (da) 1989-09-15
US5077295A (en) 1991-12-31
NO911042D0 (no) 1991-03-15
KR900004730A (ko) 1990-04-12
IL91552A (en) 1994-02-27
DK456389A (da) 1990-03-17

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