KR900004730A - 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교결합된 이환상 이미드 - Google Patents
정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교결합된 이환상 이미드 Download PDFInfo
- Publication number
- KR900004730A KR900004730A KR1019890013262A KR890013262A KR900004730A KR 900004730 A KR900004730 A KR 900004730A KR 1019890013262 A KR1019890013262 A KR 1019890013262A KR 890013262 A KR890013262 A KR 890013262A KR 900004730 A KR900004730 A KR 900004730A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- compound
- benzisothiazolyl
- piperazinyl
- butyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 일반식(Ⅰ)의 화합물 또는 그의 약학적으로 허용되는 산 부가염.상기식에서, R1및 R2는 각각 동일하거나 상이할 수 있으며, 수소, 메틸 또는 에틸이고; X는 -CH2-, -CH2CH2- 또는 -CH2CH2CH2-이며; Y는 CR3R4(여기서 R3및 R4는 각각 동일하거나 상이할 수 있으며, 수소 또는 메틸이다)이다.
- 제1항에 있어서, R1및 R2는 각각 수소이며; Y는 CH2이고; X는 -CH2-인 화합물.
- 제1항에 있어서, R1이 메틸이고; R2는 수소이며; Y는 CH2이고; X는 -CH2CH2-인 화합물.
- 제1항에 있어서, R1이 메틸이고; R2는 수소이며; Y는 C(CH3)2이고; X는 -CH2CH2-인 화합물.
- 환자의 정신병 치료용 약물의 제조를 위한 제1항에 따른 화합물의 용도.
- 정신병 치료 유효량의 제1항에 따른 화합물 및 약학적으로 허용되는 담체를 함유하는 정신병 치료 활성을 갖는 약학 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
USPCT/US83/03230 | 1988-09-16 | ||
US88-03230 | 1988-09-16 | ||
PCT/US1988/003230 WO1990002552A1 (en) | 1988-09-16 | 1988-09-16 | Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900004730A true KR900004730A (ko) | 1990-04-12 |
KR930002568B1 KR930002568B1 (ko) | 1993-04-03 |
Family
ID=22208913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890013262A KR930002568B1 (ko) | 1988-09-16 | 1989-09-12 | 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교 결합된 이환상 이미드 |
Country Status (20)
Country | Link |
---|---|
US (1) | US5077295A (ko) |
EP (1) | EP0364091B1 (ko) |
JP (1) | JPH0631231B2 (ko) |
KR (1) | KR930002568B1 (ko) |
AT (1) | ATE92063T1 (ko) |
AU (1) | AU607354B2 (ko) |
CA (1) | CA1339314C (ko) |
DE (1) | DE68907845T2 (ko) |
DK (1) | DK175200B1 (ko) |
ES (1) | ES2058542T3 (ko) |
FI (1) | FI911285A0 (ko) |
HU (1) | HUT61760A (ko) |
IE (1) | IE61413B1 (ko) |
IL (1) | IL91552A (ko) |
MY (1) | MY104207A (ko) |
NO (1) | NO911042L (ko) |
NZ (1) | NZ230672A (ko) |
PT (1) | PT91703B (ko) |
WO (1) | WO1990002552A1 (ko) |
ZA (1) | ZA897049B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5235283A (en) * | 1991-02-07 | 1993-08-10 | Siemens Aktiengesellschaft | Gradient coil system for a nuclear magnetic resonance tomography apparatus which reduces acoustic noise |
EP0790236B1 (en) * | 1996-02-13 | 2003-11-19 | Pfizer Inc. | Pro-drugs of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one |
US6084097A (en) * | 1997-10-20 | 2000-07-04 | Council Of Scientific & Industrial Research | Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl] propanes |
US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4507303A (en) * | 1981-12-22 | 1985-03-26 | Sumitomo Chemical Company, Limited | Succinimide derivatives, compositions and method of use |
US4452799A (en) * | 1981-12-23 | 1984-06-05 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
JPS5995267A (ja) * | 1982-11-25 | 1984-06-01 | Eisai Co Ltd | カルボン酸イミド誘導体およびその製造方法 |
US4524206A (en) * | 1983-09-12 | 1985-06-18 | Mead Johnson & Company | 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives |
US4562255A (en) * | 1984-03-30 | 1985-12-31 | American Home Products Corporation | Substituted bi-alicyclic imides |
US4585773A (en) * | 1984-07-11 | 1986-04-29 | Bristol-Myers Company | Isoindolinyl-alkyl-piperazines |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
JPH0625181B2 (ja) * | 1985-03-27 | 1994-04-06 | 住友製薬株式会社 | 新規なイミド誘導体 |
US4656173A (en) * | 1985-04-24 | 1987-04-07 | Bristol-Myers Company | Antipsychotic benzisothiazole S-oxide compound |
HUT43600A (en) * | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
US4732984A (en) * | 1985-10-17 | 1988-03-22 | American Home Products Corporation | Piperazinoisothiazolones with psychotropic activity |
JPS6310786A (ja) * | 1986-07-01 | 1988-01-18 | Sumitomo Pharmaceut Co Ltd | 新規イミド誘導体およびその製造法 |
JPS6310760A (ja) * | 1986-07-01 | 1988-01-18 | Sumitomo Pharmaceut Co Ltd | イミド誘導体の新規製造法 |
DD263531A5 (de) * | 1986-10-21 | 1989-01-04 | ������@���Kk�� | Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen |
US4748240A (en) * | 1987-04-03 | 1988-05-31 | American Home Products Corporation | Psychotropic bicyclic imides |
US4883795A (en) * | 1988-01-22 | 1989-11-28 | Pfizer Inc. | Piperazinyl-heterocyclic compounds |
JPH0310760A (ja) * | 1989-06-09 | 1991-01-18 | Nippon Spindle Mfg Co Ltd | 結晶質脆性材料切断用ワイヤソー |
-
1988
- 1988-09-16 HU HU892131A patent/HUT61760A/hu unknown
- 1988-09-16 US US07/659,407 patent/US5077295A/en not_active Expired - Lifetime
- 1988-09-16 WO PCT/US1988/003230 patent/WO1990002552A1/en active Application Filing
-
1989
- 1989-08-22 EP EP89308479A patent/EP0364091B1/en not_active Expired - Lifetime
- 1989-08-22 ES ES89308479T patent/ES2058542T3/es not_active Expired - Lifetime
- 1989-08-22 AT AT89308479T patent/ATE92063T1/de not_active IP Right Cessation
- 1989-08-22 DE DE89308479T patent/DE68907845T2/de not_active Expired - Fee Related
- 1989-09-07 IL IL9155289A patent/IL91552A/en not_active IP Right Cessation
- 1989-09-12 KR KR1019890013262A patent/KR930002568B1/ko not_active IP Right Cessation
- 1989-09-13 PT PT91703A patent/PT91703B/pt not_active IP Right Cessation
- 1989-09-13 JP JP1238347A patent/JPH0631231B2/ja not_active Expired - Fee Related
- 1989-09-14 CA CA000611376A patent/CA1339314C/en not_active Expired - Fee Related
- 1989-09-14 MY MYPI89001253A patent/MY104207A/en unknown
- 1989-09-15 NZ NZ230672A patent/NZ230672A/en unknown
- 1989-09-15 AU AU41506/89A patent/AU607354B2/en not_active Ceased
- 1989-09-15 IE IE294989A patent/IE61413B1/en not_active IP Right Cessation
- 1989-09-15 ZA ZA897049A patent/ZA897049B/xx unknown
- 1989-09-15 DK DK198904563A patent/DK175200B1/da not_active IP Right Cessation
-
1991
- 1991-03-15 NO NO91911042A patent/NO911042L/no unknown
- 1991-03-15 FI FI911285A patent/FI911285A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL91552A (en) | 1994-02-27 |
PT91703B (pt) | 1995-07-18 |
NO911042L (no) | 1991-05-15 |
EP0364091A1 (en) | 1990-04-18 |
ATE92063T1 (de) | 1993-08-15 |
DK175200B1 (da) | 2004-07-05 |
CA1339314C (en) | 1997-08-19 |
ES2058542T3 (es) | 1994-11-01 |
AU4150689A (en) | 1990-03-22 |
NO911042D0 (no) | 1991-03-15 |
PT91703A (pt) | 1990-03-30 |
DE68907845T2 (de) | 1993-11-11 |
DE68907845D1 (de) | 1993-09-02 |
ZA897049B (en) | 1991-04-24 |
IE61413B1 (en) | 1994-11-02 |
MY104207A (en) | 1994-02-28 |
IL91552A0 (en) | 1990-04-29 |
AU607354B2 (en) | 1991-02-28 |
EP0364091B1 (en) | 1993-07-28 |
KR930002568B1 (ko) | 1993-04-03 |
FI911285A0 (fi) | 1991-03-15 |
WO1990002552A1 (en) | 1990-03-22 |
JPH02121986A (ja) | 1990-05-09 |
IE892949L (en) | 1990-03-16 |
HUT61760A (en) | 1993-03-01 |
JPH0631231B2 (ja) | 1994-04-27 |
NZ230672A (en) | 1990-12-21 |
DK456389A (da) | 1990-03-17 |
DK456389D0 (da) | 1989-09-15 |
US5077295A (en) | 1991-12-31 |
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