KR900004730A - 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교결합된 이환상 이미드 - Google Patents

정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교결합된 이환상 이미드 Download PDF

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Publication number
KR900004730A
KR900004730A KR1019890013262A KR890013262A KR900004730A KR 900004730 A KR900004730 A KR 900004730A KR 1019890013262 A KR1019890013262 A KR 1019890013262A KR 890013262 A KR890013262 A KR 890013262A KR 900004730 A KR900004730 A KR 900004730A
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South Korea
Prior art keywords
hydrogen
compound
benzisothiazolyl
piperazinyl
butyl
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KR1019890013262A
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KR930002568B1 (ko
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마이클 브라이트 진
Ⅲ 죤 아담스 로우
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윌리암 데이비스 헌
화이자 인코포레이티드
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Publication of KR900004730A publication Critical patent/KR900004730A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐}부틸 가교결합된 이환상 이미드
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(Ⅰ)의 화합물 또는 그의 약학적으로 허용되는 산 부가염.
    상기식에서, R1및 R2는 각각 동일하거나 상이할 수 있으며, 수소, 메틸 또는 에틸이고; X는 -CH2-, -CH2CH2- 또는 -CH2CH2CH2-이며; Y는 CR3R4(여기서 R3및 R4는 각각 동일하거나 상이할 수 있으며, 수소 또는 메틸이다)이다.
  2. 제1항에 있어서, R1및 R2는 각각 수소이며; Y는 CH2이고; X는 -CH2-인 화합물.
  3. 제1항에 있어서, R1이 메틸이고; R2는 수소이며; Y는 CH2이고; X는 -CH2CH2-인 화합물.
  4. 제1항에 있어서, R1이 메틸이고; R2는 수소이며; Y는 C(CH3)2이고; X는 -CH2CH2-인 화합물.
  5. 환자의 정신병 치료용 약물의 제조를 위한 제1항에 따른 화합물의 용도.
  6. 정신병 치료 유효량의 제1항에 따른 화합물 및 약학적으로 허용되는 담체를 함유하는 정신병 치료 활성을 갖는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013262A 1988-09-16 1989-09-12 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교 결합된 이환상 이미드 KR930002568B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1988/003230 WO1990002552A1 (en) 1988-09-16 1988-09-16 Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
USPCT/US83/03230 1988-09-16
US88-03230 1988-09-16

Publications (2)

Publication Number Publication Date
KR900004730A true KR900004730A (ko) 1990-04-12
KR930002568B1 KR930002568B1 (ko) 1993-04-03

Family

ID=22208913

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013262A KR930002568B1 (ko) 1988-09-16 1989-09-12 정신병 치료제인 4-[4-(3-벤즈이소티아졸릴)-1-피페라지닐]부틸 가교 결합된 이환상 이미드

Country Status (20)

Country Link
US (1) US5077295A (ko)
EP (1) EP0364091B1 (ko)
JP (1) JPH0631231B2 (ko)
KR (1) KR930002568B1 (ko)
AT (1) ATE92063T1 (ko)
AU (1) AU607354B2 (ko)
CA (1) CA1339314C (ko)
DE (1) DE68907845T2 (ko)
DK (1) DK175200B1 (ko)
ES (1) ES2058542T3 (ko)
FI (1) FI911285A0 (ko)
HU (1) HUT61760A (ko)
IE (1) IE61413B1 (ko)
IL (1) IL91552A (ko)
MY (1) MY104207A (ko)
NO (1) NO911042L (ko)
NZ (1) NZ230672A (ko)
PT (1) PT91703B (ko)
WO (1) WO1990002552A1 (ko)
ZA (1) ZA897049B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235283A (en) * 1991-02-07 1993-08-10 Siemens Aktiengesellschaft Gradient coil system for a nuclear magnetic resonance tomography apparatus which reduces acoustic noise
PT790236E (pt) * 1996-02-13 2004-04-30 Pfizer Pro-farmacos de 5-(2-(4-(1,2-benzisotiazol-3-il)-1-piperazinil)-etil-6-cloro-1,3-di-hidro-2h-indol-2-ona
US6084097A (en) * 1997-10-20 2000-07-04 Council Of Scientific & Industrial Research Methods for preparing 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl] propanes
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4507303A (en) * 1981-12-22 1985-03-26 Sumitomo Chemical Company, Limited Succinimide derivatives, compositions and method of use
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
JPS5995267A (ja) * 1982-11-25 1984-06-01 Eisai Co Ltd カルボン酸イミド誘導体およびその製造方法
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4585773A (en) * 1984-07-11 1986-04-29 Bristol-Myers Company Isoindolinyl-alkyl-piperazines
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
JPH0625181B2 (ja) * 1985-03-27 1994-04-06 住友製薬株式会社 新規なイミド誘導体
US4656173A (en) * 1985-04-24 1987-04-07 Bristol-Myers Company Antipsychotic benzisothiazole S-oxide compound
NL8601494A (nl) * 1985-06-22 1987-01-16 Sandoz Ag Thiazolen, hun bereiding en farmaceutische preparaten die ze bevatten.
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
DD263531A5 (de) * 1986-10-21 1989-01-04 ������@���Kk�� Verfahren zur herstellung von verbrueckten bicyclischen imidverbindungen
US4748240A (en) * 1987-04-03 1988-05-31 American Home Products Corporation Psychotropic bicyclic imides
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JPH0310760A (ja) * 1989-06-09 1991-01-18 Nippon Spindle Mfg Co Ltd 結晶質脆性材料切断用ワイヤソー

Also Published As

Publication number Publication date
DK456389A (da) 1990-03-17
ATE92063T1 (de) 1993-08-15
NO911042L (no) 1991-05-15
MY104207A (en) 1994-02-28
IE61413B1 (en) 1994-11-02
FI911285A0 (fi) 1991-03-15
KR930002568B1 (ko) 1993-04-03
NZ230672A (en) 1990-12-21
DK456389D0 (da) 1989-09-15
DE68907845D1 (de) 1993-09-02
EP0364091A1 (en) 1990-04-18
IL91552A0 (en) 1990-04-29
WO1990002552A1 (en) 1990-03-22
ES2058542T3 (es) 1994-11-01
PT91703B (pt) 1995-07-18
AU607354B2 (en) 1991-02-28
ZA897049B (en) 1991-04-24
JPH02121986A (ja) 1990-05-09
US5077295A (en) 1991-12-31
CA1339314C (en) 1997-08-19
IL91552A (en) 1994-02-27
JPH0631231B2 (ja) 1994-04-27
HUT61760A (en) 1993-03-01
NO911042D0 (no) 1991-03-15
DK175200B1 (da) 2004-07-05
EP0364091B1 (en) 1993-07-28
IE892949L (en) 1990-03-16
AU4150689A (en) 1990-03-22
PT91703A (pt) 1990-03-30
DE68907845T2 (de) 1993-11-11

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