NO150436C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivater - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivaterInfo
- Publication number
- NO150436C NO150436C NO803547A NO803547A NO150436C NO 150436 C NO150436 C NO 150436C NO 803547 A NO803547 A NO 803547A NO 803547 A NO803547 A NO 803547A NO 150436 C NO150436 C NO 150436C
- Authority
- NO
- Norway
- Prior art keywords
- phenylamino
- preparation
- therapeutic active
- imidazoline derivatives
- analogue procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000000059 bradycardiac effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792947563 DE2947563A1 (de) | 1979-11-26 | 1979-11-26 | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO803547L NO803547L (no) | 1981-05-27 |
| NO150436B NO150436B (no) | 1984-07-09 |
| NO150436C true NO150436C (no) | 1984-10-17 |
Family
ID=6086893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO803547A NO150436C (no) | 1979-11-26 | 1980-11-25 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4361575A (no) |
| EP (1) | EP0029505B1 (no) |
| JP (1) | JPS5687568A (no) |
| AT (1) | ATE9333T1 (no) |
| AU (1) | AU539870B2 (no) |
| DE (2) | DE2947563A1 (no) |
| DK (1) | DK146688C (no) |
| ES (2) | ES8201140A1 (no) |
| FI (1) | FI68616C (no) |
| IE (1) | IE50570B1 (no) |
| IL (1) | IL61560A (no) |
| NO (1) | NO150436C (no) |
| ZA (1) | ZA807337B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2499991A1 (fr) * | 1981-02-19 | 1982-08-20 | Sandoz Sa | Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| DE3514351A1 (de) * | 1985-04-20 | 1986-11-06 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| AU704972B2 (en) | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US6737433B1 (en) * | 2002-12-16 | 2004-05-18 | Laboratoire Theramex | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759048A (fr) * | 1969-11-17 | 1971-05-17 | Boehringer Sohn Ingelheim | Nouvelles n-aminoalcoyl-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
| BE759125A (fr) * | 1969-11-19 | 1971-05-18 | Boehringer Sohn Ingelheim | Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
| US3850926A (en) * | 1971-01-21 | 1974-11-26 | Boehringer Sohn Ingelheim | 2-(n-substituted-phenylamino)-imidazolines-(2) |
| BE787683A (fr) * | 1971-08-20 | 1973-02-19 | Boehringer Sohn Ingelheim | 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| DE2259160A1 (de) * | 1972-12-02 | 1974-06-06 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylaminoimidazoline, deren saeureadditionssalze und verfahren zur herstellung derselben sowie ihre verwendung als arzneimittel |
| DE2457979A1 (de) * | 1974-12-07 | 1976-06-16 | Beiersdorf Ag | 2-n-aryl-hydroxyamino-imidazoline-(2) und verfahren zu deren herstellung |
| DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2636732A1 (de) * | 1976-08-14 | 1978-02-16 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino- imidazoline- (2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2830278A1 (de) * | 1978-07-10 | 1980-01-31 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2831234A1 (de) * | 1978-07-15 | 1980-01-31 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2) deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
| DE2831671A1 (de) * | 1978-07-19 | 1980-02-07 | Boehringer Sohn Ingelheim | Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
-
1979
- 1979-11-26 DE DE19792947563 patent/DE2947563A1/de not_active Withdrawn
-
1980
- 1980-10-21 AT AT80106396T patent/ATE9333T1/de not_active IP Right Cessation
- 1980-10-21 DE DE8080106396T patent/DE3069173D1/de not_active Expired
- 1980-10-21 EP EP80106396A patent/EP0029505B1/de not_active Expired
- 1980-11-24 FI FI803654A patent/FI68616C/fi not_active IP Right Cessation
- 1980-11-25 DK DK501480A patent/DK146688C/da active
- 1980-11-25 NO NO803547A patent/NO150436C/no unknown
- 1980-11-25 JP JP16577780A patent/JPS5687568A/ja active Pending
- 1980-11-25 ES ES497105A patent/ES8201140A1/es not_active Expired
- 1980-11-25 AU AU64691/80A patent/AU539870B2/en not_active Ceased
- 1980-11-25 IE IE2445/80A patent/IE50570B1/en unknown
- 1980-11-25 ZA ZA00807337A patent/ZA807337B/xx unknown
- 1980-11-25 IL IL61560A patent/IL61560A/xx unknown
-
1981
- 1981-06-23 US US06/276,703 patent/US4361575A/en not_active Expired - Fee Related
- 1981-10-08 ES ES506103A patent/ES8301219A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2947563A1 (de) | 1981-06-04 |
| DE3069173D1 (en) | 1984-10-18 |
| IL61560A (en) | 1984-09-30 |
| NO150436B (no) | 1984-07-09 |
| NO803547L (no) | 1981-05-27 |
| AU6469180A (en) | 1981-06-04 |
| ES506103A0 (es) | 1982-11-16 |
| ES497105A0 (es) | 1981-12-01 |
| ES8301219A1 (es) | 1982-11-16 |
| EP0029505A1 (de) | 1981-06-03 |
| IE50570B1 (en) | 1986-05-14 |
| ATE9333T1 (de) | 1984-09-15 |
| JPS5687568A (en) | 1981-07-16 |
| FI803654L (fi) | 1981-05-27 |
| EP0029505B1 (de) | 1984-09-12 |
| FI68616C (fi) | 1985-10-10 |
| IE802445L (en) | 1981-05-26 |
| FI68616B (fi) | 1985-06-28 |
| ZA807337B (en) | 1982-08-25 |
| DK146688B (da) | 1983-12-05 |
| ES8201140A1 (es) | 1981-12-01 |
| US4361575A (en) | 1982-11-30 |
| AU539870B2 (en) | 1984-10-18 |
| DK501480A (da) | 1981-05-27 |
| IL61560A0 (en) | 1980-12-31 |
| DK146688C (da) | 1984-05-21 |
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