KR900003154A - 우울증 치료제인 n-치환된 니코틴아미드 화합물 - Google Patents
우울증 치료제인 n-치환된 니코틴아미드 화합물 Download PDFInfo
- Publication number
- KR900003154A KR900003154A KR1019890012412A KR890012412A KR900003154A KR 900003154 A KR900003154 A KR 900003154A KR 1019890012412 A KR1019890012412 A KR 1019890012412A KR 890012412 A KR890012412 A KR 890012412A KR 900003154 A KR900003154 A KR 900003154A
- Authority
- KR
- South Korea
- Prior art keywords
- fluoro
- chloro
- benzyl
- compound
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식의 화합물 또는 이의 약제학적 허용가능한 산 부가염.상기식에서, R3는 1-피페리딜, 1-(3-인돌릴)에틸(C1-4)-알킬, 페닐, 벤질, 1-(1-페닐에틸)또는 일치환된 벤질(여기에서 치환체는 클로로, 플루오로, 메틸 또는 메톡시이다)이고; R4는 바이시클로[2.2.1]헵트-2-일 또는(여기에서 Y는 수소, 플루오로 또는 클로로이고; X는 수소, 플루오로, 클로로, 메톡시, 트리플루오로메틸, 시아노, 카복시, 메틸카바모일, 디메틸카바모일 또는 카보(C1-4)알콕시이다)이며; 단 R3가 페닐, 벤질, 일치환된 벤질, 1-(1-페닐에틸) 또는 (C1-4)알킬이며, R4는 바이시클로[2.2.1]헵트-2-일이다.
- 제1항에 있어서, R3가 1-피페리딜 또는 1-(3-인돌릴)에틸인 화합물.
- 제2항에 있어서, R3가 1-(3-인돌릴)에틸이고 R4가 바이시클로[2.2.1]헵트-2-일인 화합물.
- 제2항에 있어서, R4가(여기에서 Y는 수소이고 X는 카보(C1-4)알콕시이다)인 화합물.
- 제4항에 있어서, R3가 1-피페리딜이고 R4가인 화합물.
- 활성치료 물질로서 사용하기 위한 하기 일반식을 갖는 화합물 또는 이의 약제학적 허용가능한 산 부가염.상기식에서 R1은 1-피페리딜, 1-(3-인돌릴)에틸, (C1-4)-알킬, 페닐, 벤질, 1-(1-페닐에틸)또는 일치환된 벤질(여기에서 치환체는 클로로, 플루오로, 메틸 또는 메톡시이다)이고; R2는 바이시클로[2.2.1]헵트-2-일 또는(여기에서 Y는 수소, 플루오로 또는 클로로이고; X는 수소, 플루오로, 클로로, 메톡시, 트리플루오로메틸, 시아노, 카복시, 메틸카바모일, 디메틸카바모일 또는 카보(C1-4)알콕시이다)이다.
- 제6항에 있어서, 우울증에 거린 사람의 우울증을 치료하기 위한 약제를 제조하기 위한 물질의 용도.
- 제7항에 있어서, R2가인 물질의 용도.
- 제8항에 있어서, R1이 벤질 또는 일치환된 벤질이고 R2가인 물질의 용도.
- 제9항에 있어서, R2가인 물질의 용도.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US238,951 | 1988-08-31 | ||
US07/238,951 US4861891A (en) | 1988-08-31 | 1988-08-31 | Antidepressant N-substituted nicotinamide compounds |
US238951 | 1999-01-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900003154A true KR900003154A (ko) | 1990-03-23 |
KR920000760B1 KR920000760B1 (ko) | 1992-01-21 |
Family
ID=22899998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890012412A KR920000760B1 (ko) | 1988-08-31 | 1989-08-30 | 우울증 치료제인 n-치환된 니코틴아미드 화합물 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4861891A (ko) |
EP (1) | EP0357316B1 (ko) |
JP (1) | JPH02115168A (ko) |
KR (1) | KR920000760B1 (ko) |
AT (1) | ATE88182T1 (ko) |
AU (1) | AU609329B2 (ko) |
CA (1) | CA1329605C (ko) |
DE (1) | DE68905979T2 (ko) |
DK (1) | DK426889A (ko) |
FI (1) | FI894066A (ko) |
HU (1) | HU208120B (ko) |
IE (1) | IE892775L (ko) |
IL (1) | IL91417A0 (ko) |
MY (1) | MY104179A (ko) |
NO (1) | NO893471L (ko) |
NZ (1) | NZ230493A (ko) |
PT (1) | PT91580B (ko) |
ZA (1) | ZA896626B (ko) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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US4973597A (en) * | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
NZ337698A (en) * | 1997-04-04 | 2001-07-27 | Pfizer Prod Inc | Nicotinamide derivatives for selective inhibition of phosphodiesterase type 4 (PDE4) and the production of tumour necrosis factor (TNF) useful for the treatment of respiratory, rheumatoid and allergic diseases |
GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
AU2700201A (en) * | 2000-01-31 | 2001-08-14 | Pfizer Products Inc. | Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of pde4 isozymes |
DK1252157T3 (da) | 2000-01-31 | 2004-10-25 | Pfizer Prod Inc | Pyrimidin-carboxamider anvendelige som inhibitorer af PDE4 isozymer |
KR100661081B1 (ko) * | 2000-06-10 | 2006-12-26 | 동화약품공업주식회사 | 항바이러스제로 유용한 6-메틸니코틴아미드 유도체 |
US7250518B2 (en) * | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
EE200300362A (et) * | 2001-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid |
IL156413A0 (en) * | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
PL364910A1 (en) | 2001-01-31 | 2004-12-27 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
GB0317472D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
JP2008503446A (ja) * | 2004-05-06 | 2008-02-07 | プレキシコン,インコーポレーテッド | Pde4b阻害剤及びその使用 |
CA2583428A1 (en) * | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
DK1951663T3 (en) * | 2005-11-24 | 2016-10-10 | Dompé Farm S P A | (r)-arylkylaminoderivater og farmaceutiske sammensætninger indeholdende dem |
WO2007098352A2 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
DE102007057089B4 (de) * | 2006-12-22 | 2010-04-29 | Lg Display Co., Ltd. | Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben |
WO2008112164A2 (en) | 2007-03-08 | 2008-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
JP2012502048A (ja) | 2008-09-08 | 2012-01-26 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | アルデヒドデヒドロゲナーゼ活性のモジュレーターおよびその使用方法 |
KR20110082180A (ko) | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4251263A (en) * | 1979-09-04 | 1981-02-17 | Stauffer Chemical Company | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof |
US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
-
1988
- 1988-08-31 US US07/238,951 patent/US4861891A/en not_active Expired - Fee Related
-
1989
- 1989-08-22 AT AT89308481T patent/ATE88182T1/de active
- 1989-08-22 DE DE8989308481T patent/DE68905979T2/de not_active Expired - Fee Related
- 1989-08-22 EP EP89308481A patent/EP0357316B1/en not_active Expired - Lifetime
- 1989-08-24 IL IL91417A patent/IL91417A0/xx unknown
- 1989-08-25 MY MYPI89001168A patent/MY104179A/en unknown
- 1989-08-29 CA CA000609655A patent/CA1329605C/en not_active Expired - Fee Related
- 1989-08-30 DK DK426889A patent/DK426889A/da not_active Application Discontinuation
- 1989-08-30 ZA ZA896626A patent/ZA896626B/xx unknown
- 1989-08-30 NO NO89893471A patent/NO893471L/no unknown
- 1989-08-30 IE IE892775A patent/IE892775L/xx unknown
- 1989-08-30 KR KR1019890012412A patent/KR920000760B1/ko not_active IP Right Cessation
- 1989-08-30 AU AU40913/89A patent/AU609329B2/en not_active Ceased
- 1989-08-30 HU HU894507A patent/HU208120B/hu not_active IP Right Cessation
- 1989-08-30 FI FI894066A patent/FI894066A/fi not_active IP Right Cessation
- 1989-08-30 PT PT91580A patent/PT91580B/pt not_active IP Right Cessation
- 1989-08-30 JP JP1224342A patent/JPH02115168A/ja active Pending
- 1989-08-30 NZ NZ230493A patent/NZ230493A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU609329B2 (en) | 1991-04-26 |
NZ230493A (en) | 1991-03-26 |
DE68905979T2 (de) | 1993-07-22 |
DK426889A (da) | 1990-03-01 |
ATE88182T1 (de) | 1993-04-15 |
NO893471D0 (no) | 1989-08-30 |
EP0357316B1 (en) | 1993-04-14 |
HU208120B (en) | 1993-08-30 |
FI894066A0 (fi) | 1989-08-30 |
AU4091389A (en) | 1990-06-28 |
NO893471L (no) | 1990-03-01 |
KR920000760B1 (ko) | 1992-01-21 |
DK426889D0 (da) | 1989-08-30 |
MY104179A (en) | 1994-02-28 |
JPH02115168A (ja) | 1990-04-27 |
PT91580B (pt) | 1995-05-04 |
EP0357316A1 (en) | 1990-03-07 |
CA1329605C (en) | 1994-05-17 |
ZA896626B (en) | 1991-04-24 |
PT91580A (pt) | 1990-03-08 |
IE892775L (en) | 1990-02-28 |
HUT52058A (en) | 1990-06-28 |
DE68905979D1 (de) | 1993-05-19 |
US4861891A (en) | 1989-08-29 |
IL91417A0 (en) | 1990-04-29 |
FI894066A (fi) | 1990-03-01 |
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