AR245718A1 - Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina - Google Patents

Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina

Info

Publication number
AR245718A1
AR245718A1 AR87308224A AR30822487A AR245718A1 AR 245718 A1 AR245718 A1 AR 245718A1 AR 87308224 A AR87308224 A AR 87308224A AR 30822487 A AR30822487 A AR 30822487A AR 245718 A1 AR245718 A1 AR 245718A1
Authority
AR
Argentina
Prior art keywords
same
compound
imidazo
pharmaceutical compositions
compositions containing
Prior art date
Application number
AR87308224A
Other languages
English (en)
Original Assignee
Tokio Tanabe Company Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokio Tanabe Company Ltd filed Critical Tokio Tanabe Company Ltd
Application granted granted Critical
Publication of AR245718A1 publication Critical patent/AR245718A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN COMPUESTO DE IMIDAZOL ¡4,5-B¿ PIRIDINA DE FORMULA (I), DONDE R1 ES ALCOXI SUSTITUIDO O NO CON CICLOALQUILO, O FLUOROALQUILOXI, R2 ES HIDROGENO, METILO O METOXI,Y R3 Y R4 SON HIDROGENO O METILO, EFECTUANDO LAS ETAPAS DE: (A) CONDENSAR UN COMPUESTO TIOL DE FORMULA (III) CON UN COMPUESTO PIRIDINA DE FORMULA (IV), EN UN SOLVENTE DE REACCION Y EN PRESENCIA O AUSENCIA DE UNA BASE, PARA OBTENER UN COMPUESTO SULFURO DE FORMULA (II); Y (B) OXIDAR EL COMPUESTO DE SULFURO RESULTANTE EN PRESENCIA DE UN SOLVENTE APROPIADO CON LA AYUDA DE UN AGENTE OXIDANTE.
AR87308224A 1986-07-25 1987-07-22 Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina AR245718A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17355186 1986-07-25
JP62133534A JPH0643426B2 (ja) 1986-07-25 1987-05-30 イミダゾ〔４，５−ｂ〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤

Publications (1)

Publication Number Publication Date
AR245718A1 true AR245718A1 (es) 1994-02-28

Family

ID=26467860

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87308224A AR245718A1 (es) 1986-07-25 1987-07-22 Procedimiento para preparar un compuesto de imidazo (4,5-b)-piridina

Country Status (14)

Country Link
US (1) US4808596A (es)
EP (1) EP0254588B1 (es)
JP (1) JPH0643426B2 (es)
KR (1) KR940002824B1 (es)
AR (1) AR245718A1 (es)
AT (1) ATE71626T1 (es)
AU (1) AU598564B2 (es)
CA (1) CA1329204C (es)
DE (1) DE3776018D1 (es)
ES (1) ES2038184T3 (es)
GR (1) GR3003777T3 (es)
HU (1) HU200458B (es)
MX (1) MX168756B (es)
ZA (1) ZA875151B (es)

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DE3579436D1 (de) * 1984-12-18 1990-10-04 Otsuka Pharma Co Ltd Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen.
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
US5200407A (en) * 1989-06-29 1993-04-06 Meiji Seika Kaburhiki Kaisha Azole derivatives and anti-ulcerative composition containing same
JP2679745B2 (ja) * 1989-06-29 1997-11-19 明治製菓株式会社 アゾール誘導体及びそれらを有効成分とする抗潰瘍剤
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IE990506A1 (en) * 1998-06-26 2000-11-15 Russinsky Ltd Pyridine Building Blocks
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US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
DE10140492A1 (de) 2001-08-17 2003-08-14 Gruenenthal Gmbh Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung
EP1534278A4 (en) 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
MY148805A (en) 2002-10-16 2013-05-31 Takeda Pharmaceutical Controlled release preparation
FR2845916B1 (fr) * 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un antagoniste des recepteurs h2 a l'histamine
FR2845915B1 (fr) 2002-10-21 2006-06-23 Negma Gild Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien
FR2845917B1 (fr) 2002-10-21 2006-07-07 Negma Gild Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire
FR2848555B1 (fr) 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
US20050220870A1 (en) * 2003-02-20 2005-10-06 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
CN100558726C (zh) 2003-02-24 2009-11-11 田边三菱制药株式会社 泰妥拉唑的对映体及其在治疗中的应用
EP1611901B1 (en) * 2003-03-13 2013-07-10 Eisai R&D Management Co., Ltd. Preventive or remedy for teeth grinding
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
AR045062A1 (es) * 2003-07-18 2005-10-12 Santarus Inc Formulaciones farmaceuticas para inhibir la secrecion de acido y metodos para preparar y utilizarlas
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
WO2005076987A2 (en) * 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
US20050239845A1 (en) * 2004-04-16 2005-10-27 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
BRPI0510251A (pt) * 2004-04-28 2007-10-23 Altana Pharma Ag derivados de dialcóxi-imidazopiridina
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TW200613301A (en) * 2004-06-15 2006-05-01 Altana Pharma Ag Novel amino-halogen-imidazopyridines
FR2871800B1 (fr) 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
CN100364989C (zh) * 2004-09-30 2008-01-30 江苏豪森药业股份有限公司 拉唑类衍生物及其盐和用途
EP1824850A2 (en) * 2004-12-09 2007-08-29 Nycomed GmbH SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS INHIBITORS OF GASTRIC ACID SECRETION
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EA016814B1 (ru) * 2005-07-26 2012-07-30 Никомед Гмбх Замещенные изотопами ингибиторы протонного насоса
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CN100376574C (zh) * 2006-06-14 2008-03-26 浙江大学 泰妥拉唑的制备方法
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
GB2444593B (en) 2006-10-05 2010-06-09 Santarus Inc Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
EP2486910A3 (en) 2006-10-27 2012-08-22 The Curators Of The University Of Missouri Multi-chambered apparatus comprising a dispenser head
FR2909380B1 (fr) * 2006-12-04 2009-02-20 Sidem Pharma Sa Sa Conglomerats de sels de potassium de tenatoprazole
CN101497616B (zh) * 2008-01-30 2011-05-18 山东轩竹医药科技有限公司 含有氨基氧基取代的吡啶的咪唑并吡啶的化合物
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
CN102725289B (zh) 2009-07-07 2015-12-02 科学与工业研究委员会 用于制备亚砜化合物的连续流方法
WO2013108068A1 (en) 2012-01-21 2013-07-25 Jubilant Life Sciences Limited Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234058A (es) * 1968-10-21 1971-06-03
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
JPS6034956A (ja) * 1983-08-04 1985-02-22 Fujisawa Pharmaceut Co Ltd 新規チアゾリウム化合物およびその製造法
DE3579436D1 (de) * 1984-12-18 1990-10-04 Otsuka Pharma Co Ltd Tetrahydrochinolin- derivate, verfahren zu deren herstellung und diese enthaltende antimagengeschwuerzusammensetzungen.
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
JPS62207271A (ja) * 1986-03-06 1987-09-11 Yamanouchi Pharmaceut Co Ltd ２−ピリジルメチルチオ基または２−ピリジルメチルスルフイニル基で置換された縮合環化合物
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
CA1329204C (en) 1994-05-03
JPS63146882A (ja) 1988-06-18
HU200458B (en) 1990-06-28
AU7562887A (en) 1988-01-28
US4808596A (en) 1989-02-28
KR880001651A (ko) 1988-04-25
ATE71626T1 (de) 1992-02-15
ES2038184T3 (es) 1993-07-16
GR3003777T3 (es) 1993-03-16
AU598564B2 (en) 1990-06-28
HUT46000A (en) 1988-09-28
EP0254588B1 (en) 1992-01-15
ZA875151B (en) 1988-01-21
KR940002824B1 (ko) 1994-04-04
MX168756B (es) 1993-06-07
DE3776018D1 (de) 1992-02-27
JPH0643426B2 (ja) 1994-06-08
EP0254588A1 (en) 1988-01-27

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