ATE78830T1 - Lactamderivate, deren herstellung und deren benutzung als hypotensive mittel. - Google Patents
Lactamderivate, deren herstellung und deren benutzung als hypotensive mittel.Info
- Publication number
- ATE78830T1 ATE78830T1 AT86307853T AT86307853T ATE78830T1 AT E78830 T1 ATE78830 T1 AT E78830T1 AT 86307853 T AT86307853 T AT 86307853T AT 86307853 T AT86307853 T AT 86307853T AT E78830 T1 ATE78830 T1 AT E78830T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- lactam derivatives
- hypotensive agent
- ch2ch2
- hypotensive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22604485 | 1985-10-11 | ||
EP86307853A EP0220865B1 (de) | 1985-10-11 | 1986-10-10 | Lactamderivate, deren Herstellung und deren Benutzung als hypotensive Mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE78830T1 true ATE78830T1 (de) | 1992-08-15 |
Family
ID=16838903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT86307853T ATE78830T1 (de) | 1985-10-11 | 1986-10-10 | Lactamderivate, deren herstellung und deren benutzung als hypotensive mittel. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4734410A (de) |
EP (1) | EP0220865B1 (de) |
JP (1) | JPH0637473B2 (de) |
KR (1) | KR910001442B1 (de) |
AT (1) | ATE78830T1 (de) |
CA (1) | CA1336711C (de) |
DE (1) | DE3686232T2 (de) |
ES (1) | ES2042497T3 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4778790A (en) * | 1986-04-04 | 1988-10-18 | Sankyo Company Limited | Perhydrothiazepine and perhydroazepine derivatives and their therapeutic use |
US4831135A (en) * | 1986-06-18 | 1989-05-16 | The Regents Of The University Of California | Bengamide anthelmintics |
GB9000846D0 (en) * | 1990-01-15 | 1990-03-14 | Beecham Group Plc | Novel compounds |
US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
RU2124503C1 (ru) | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
KR950703539A (ko) * | 1992-09-28 | 1995-09-20 | 알렌 제이. 스피겔 | 당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications) |
US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
USD731632S1 (en) | 2012-12-04 | 2015-06-09 | Dri-Eaz Products, Inc. | Compact dehumidifier |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4629787A (en) * | 1980-08-18 | 1986-12-16 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
US4680392A (en) * | 1980-08-18 | 1987-07-14 | Merck & Co., Inc. | Substituted caprolactam derivatives as antihypertensives |
GR74635B (de) * | 1980-08-18 | 1984-06-29 | Merck & Co Inc | |
PT73522B (en) * | 1980-08-18 | 1983-07-14 | Merck & Co Inc | Process for preparing substituted caprylolactam derivatives as antihypertensives |
US4587050A (en) * | 1980-08-18 | 1986-05-06 | Merck & Co., Inc. | Substituted enantholactam derivatives as antihypertensives |
US4474778A (en) * | 1983-11-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Lactam containing compounds, their pharmaceutical compositions and method of use |
US4699905A (en) * | 1984-04-10 | 1987-10-13 | Sankyo Company, Limited | Perhydrothiazepine derivatives, their preparation and their therapeutic use |
-
1986
- 1986-10-02 JP JP61235178A patent/JPH0637473B2/ja not_active Expired - Lifetime
- 1986-10-09 US US06/917,041 patent/US4734410A/en not_active Expired - Lifetime
- 1986-10-10 DE DE8686307853T patent/DE3686232T2/de not_active Expired - Fee Related
- 1986-10-10 ES ES86307853T patent/ES2042497T3/es not_active Expired - Lifetime
- 1986-10-10 AT AT86307853T patent/ATE78830T1/de not_active IP Right Cessation
- 1986-10-10 CA CA000520293A patent/CA1336711C/en not_active Expired - Fee Related
- 1986-10-10 EP EP86307853A patent/EP0220865B1/de not_active Expired - Lifetime
- 1986-10-11 KR KR1019860008550A patent/KR910001442B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS62174056A (ja) | 1987-07-30 |
EP0220865B1 (de) | 1992-07-29 |
EP0220865A2 (de) | 1987-05-06 |
KR910001442B1 (ko) | 1991-03-07 |
DE3686232T2 (de) | 1993-03-25 |
KR870003992A (ko) | 1987-05-06 |
CA1336711C (en) | 1995-08-15 |
EP0220865A3 (en) | 1989-01-18 |
US4734410A (en) | 1988-03-29 |
JPH0637473B2 (ja) | 1994-05-18 |
ES2042497T3 (es) | 1993-12-16 |
DE3686232D1 (de) | 1992-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |