MX168756B - PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE IMIDAZO (4,5-b) PIRIDINA - Google Patents
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE IMIDAZO (4,5-b) PIRIDINAInfo
- Publication number
- MX168756B MX168756B MX007489A MX748987A MX168756B MX 168756 B MX168756 B MX 168756B MX 007489 A MX007489 A MX 007489A MX 748987 A MX748987 A MX 748987A MX 168756 B MX168756 B MX 168756B
- Authority
- MX
- Mexico
- Prior art keywords
- group
- compound
- general formula
- procedure
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para preparar un compuesto de imidazo (4,5-b)piridina, de la fórmula general: en la cual R1 es un grupo alquilo, de cadena recta o ramificada, con 1 a 8 átomos de carbono, que puede estar substituído con un grupo cicloalquilo o un grupo fluoroalquiloxi con 2 a 4 átomos de carbono; R2 es un átomo de hidrógeno, un grupo metilo o un grupo metoxi; y R3 y R4 son cada uno un átomo de hidrógeno o un grupo metilo, y pueden ser iguales o diferentes, el cual comprende las etapas de: a) condensar un compuesto de tiol, de la fórmula general: en que R1 es como se definió previamente, con un compuesto de piridina, de la fórmula general: en que R2, R3 y R4 tienen las definiciones anteriores, en un solvente de reacción, en la presencia o ausencia de una base, para obtener un compuesto de sulfuro, de la fórmula general: enq ue R1, R2, R3 y R4 tienen las definiciones anteriores; y b) oxidar el compuesto de sulfuro resultante en la presencia de un solvente adecuado y con la ayuda de un agente oxidante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17355186 | 1986-07-25 | ||
JP62133534A JPH0643426B2 (ja) | 1986-07-25 | 1987-05-30 | イミダゾ〔4,5−b〕ピリジン誘導体、その製造法及びそれを含有する抗潰瘍剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX168756B true MX168756B (es) | 1993-06-07 |
Family
ID=26467860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX007489A MX168756B (es) | 1986-07-25 | 1987-07-24 | PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE IMIDAZO (4,5-b) PIRIDINA |
Country Status (14)
Country | Link |
---|---|
US (1) | US4808596A (es) |
EP (1) | EP0254588B1 (es) |
JP (1) | JPH0643426B2 (es) |
KR (1) | KR940002824B1 (es) |
AR (1) | AR245718A1 (es) |
AT (1) | ATE71626T1 (es) |
AU (1) | AU598564B2 (es) |
CA (1) | CA1329204C (es) |
DE (1) | DE3776018D1 (es) |
ES (1) | ES2038184T3 (es) |
GR (1) | GR3003777T3 (es) |
HU (1) | HU200458B (es) |
MX (1) | MX168756B (es) |
ZA (1) | ZA875151B (es) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL71664A (en) * | 1983-05-03 | 1987-11-30 | Byk Gulden Lomberg Chem Fab | Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same |
DK585485A (da) * | 1984-12-18 | 1986-08-08 | Utsuka Pharm Co Ltd | Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse |
KR950001015B1 (ko) * | 1986-01-10 | 1995-02-07 | 닛뽕 케미화 가부시끼가이샤 | 술폭시드 유도체의 제조방법 |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
JP2679745B2 (ja) * | 1989-06-29 | 1997-11-19 | 明治製菓株式会社 | アゾール誘導体及びそれらを有効成分とする抗潰瘍剤 |
US5200407A (en) * | 1989-06-29 | 1993-04-06 | Meiji Seika Kaburhiki Kaisha | Azole derivatives and anti-ulcerative composition containing same |
ZW1992A1 (en) * | 1991-02-25 | 1993-09-22 | Janssen Pharmaceutica Nv | 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol |
NZ244301A (en) * | 1991-09-20 | 1994-08-26 | Merck & Co Inc | Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds |
ZA945609B (en) * | 1993-07-28 | 1995-05-12 | Rhone Poulenc Rorer Ltd | [Di(ether or thioether)heteroaryl or fluoro substituted aryl] compounds |
US6051570A (en) * | 1997-05-30 | 2000-04-18 | Dr. Reddy's Research Foundation | Benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them |
WO2000000474A1 (en) * | 1998-06-26 | 2000-01-06 | Russinsky Limited | Pyridine building blocks as intermediates in the synthesis of pharmaceutically active compounds |
US6166213A (en) * | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
US6268385B1 (en) | 1999-08-26 | 2001-07-31 | Robert R. Whittle | Dry blend pharmaceutical formulations |
US6316020B1 (en) | 1999-08-26 | 2001-11-13 | Robert R. Whittle | Pharmaceutical formulations |
US6262086B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6312723B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Pharmaceutical unit dosage form |
US6312712B1 (en) | 1999-08-26 | 2001-11-06 | Robert R. Whittle | Method of improving bioavailability |
US6262085B1 (en) | 1999-08-26 | 2001-07-17 | Robert R. Whittle | Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US6326384B1 (en) | 1999-08-26 | 2001-12-04 | Robert R. Whittle | Dry blend pharmaceutical unit dosage form |
US6780880B1 (en) | 1999-08-26 | 2004-08-24 | Robert R. Whittle | FT-Raman spectroscopic measurement |
DE10140492A1 (de) | 2001-08-17 | 2003-08-14 | Gruenenthal Gmbh | Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung |
US7211590B2 (en) | 2002-08-01 | 2007-05-01 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
FR2845915B1 (fr) | 2002-10-21 | 2006-06-23 | Negma Gild | Utilisation du tenatoprazole pour le traitement du reflux gastro-oesophagien |
FR2845917B1 (fr) * | 2002-10-21 | 2006-07-07 | Negma Gild | Composition pharmaceutique associant le tenatoprazole et un anti-inflammatoire |
FR2845916B1 (fr) * | 2002-10-21 | 2006-07-07 | Negma Gild | Composition pharmaceutique associant le tenatoprazole et un antagoniste des recepteurs h2 a l'histamine |
FR2848555B1 (fr) | 2002-12-16 | 2006-07-28 | Negma Gild | Enantiomere(-)du tenatoprazole et son application en therapeutique |
US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
KR20120102571A (ko) | 2003-02-24 | 2012-09-18 | 미쓰비시 타나베 파마 코퍼레이션 | 테나토프라졸의 거울상 이성질체 및 치료를 위한 그 용도 |
EP1611901B1 (en) * | 2003-03-13 | 2013-07-10 | Eisai R&D Management Co., Ltd. | Preventive or remedy for teeth grinding |
TWI337877B (en) * | 2003-07-18 | 2011-03-01 | Santarus Inc | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
EP1718303A4 (en) * | 2004-02-10 | 2010-09-01 | Santarus Inc | COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG |
CA2561700A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
TW200606163A (en) * | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
CN1946722A (zh) * | 2004-04-28 | 2007-04-11 | 奥坦纳医药公司 | 二烷氧基咪唑并吡啶衍生物 |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
TW200613301A (en) * | 2004-06-15 | 2006-05-01 | Altana Pharma Ag | Novel amino-halogen-imidazopyridines |
FR2871800B1 (fr) * | 2004-06-17 | 2006-08-25 | Sidem Pharma Sa Sa | Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique |
CN100364989C (zh) * | 2004-09-30 | 2008-01-30 | 江苏豪森药业股份有限公司 | 拉唑类衍生物及其盐和用途 |
WO2006061380A2 (en) * | 2004-12-09 | 2006-06-15 | Altana Pharma Ag | SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS INHIBITORS OF GASTRIC ACID SECRETION |
US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
US7601737B2 (en) | 2005-07-26 | 2009-10-13 | Nycomed Gmbh | Isotopically substituted proton pump inhibitors |
KR101358509B1 (ko) * | 2005-07-26 | 2014-02-05 | 다케다 게엠베하 | 동위 원소 치환된 양성자 펌프 억제제 |
CN1982311B (zh) * | 2005-12-13 | 2010-10-13 | 天津维智精细化工有限公司 | 2-巯基-5-甲氧基咪唑[4,5-b]并吡啶的合成工艺 |
CN100376574C (zh) * | 2006-06-14 | 2008-03-26 | 浙江大学 | 泰妥拉唑的制备方法 |
WO2008036201A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
EP2068841B1 (en) | 2006-10-05 | 2018-09-26 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
EP2486910A3 (en) | 2006-10-27 | 2012-08-22 | The Curators Of The University Of Missouri | Multi-chambered apparatus comprising a dispenser head |
FR2909380B1 (fr) * | 2006-12-04 | 2009-02-20 | Sidem Pharma Sa Sa | Conglomerats de sels de potassium de tenatoprazole |
CN101497616B (zh) * | 2008-01-30 | 2011-05-18 | 山东轩竹医药科技有限公司 | 含有氨基氧基取代的吡啶的咪唑并吡啶的化合物 |
US8247440B2 (en) | 2008-02-20 | 2012-08-21 | Curators Of The University Of Missouri | Composition comprising omeprazole, lansoprazole and at least one buffering agent |
ES2445711T3 (es) | 2009-07-07 | 2014-03-04 | Council Of Scientific & Industrial Research | Procedimiento de flujo continuo para la preparación de compuestos de sulfóxido |
WO2013108068A1 (en) | 2012-01-21 | 2013-07-25 | Jubilant Life Sciences Limited | Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers |
WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1234058A (es) * | 1968-10-21 | 1971-06-03 | ||
IL71664A (en) * | 1983-05-03 | 1987-11-30 | Byk Gulden Lomberg Chem Fab | Fluoroalkoxy compounds,process for their preparation and pharmaceutical compositions containing the same |
JPS6034956A (ja) * | 1983-08-04 | 1985-02-22 | Fujisawa Pharmaceut Co Ltd | 新規チアゾリウム化合物およびその製造法 |
DK585485A (da) * | 1984-12-18 | 1986-08-08 | Utsuka Pharm Co Ltd | Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse |
KR950001015B1 (ko) * | 1986-01-10 | 1995-02-07 | 닛뽕 케미화 가부시끼가이샤 | 술폭시드 유도체의 제조방법 |
JPS62207271A (ja) * | 1986-03-06 | 1987-09-11 | Yamanouchi Pharmaceut Co Ltd | 2−ピリジルメチルチオ基または2−ピリジルメチルスルフイニル基で置換された縮合環化合物 |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
-
1987
- 1987-05-30 JP JP62133534A patent/JPH0643426B2/ja not_active Expired - Lifetime
- 1987-07-14 AU AU75628/87A patent/AU598564B2/en not_active Expired
- 1987-07-14 ZA ZA875151A patent/ZA875151B/xx unknown
- 1987-07-21 CA CA000542637A patent/CA1329204C/en not_active Expired - Lifetime
- 1987-07-22 AR AR87308224A patent/AR245718A1/es active
- 1987-07-24 MX MX007489A patent/MX168756B/es unknown
- 1987-07-24 ES ES198787306570T patent/ES2038184T3/es not_active Expired - Lifetime
- 1987-07-24 US US07/077,686 patent/US4808596A/en not_active Expired - Lifetime
- 1987-07-24 KR KR1019870008092A patent/KR940002824B1/ko not_active IP Right Cessation
- 1987-07-24 AT AT87306570T patent/ATE71626T1/de not_active IP Right Cessation
- 1987-07-24 EP EP87306570A patent/EP0254588B1/en not_active Expired - Lifetime
- 1987-07-24 DE DE8787306570T patent/DE3776018D1/de not_active Expired - Lifetime
- 1987-07-24 HU HU873407A patent/HU200458B/hu unknown
-
1992
- 1992-02-11 GR GR920400203T patent/GR3003777T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA875151B (en) | 1988-01-21 |
ES2038184T3 (es) | 1993-07-16 |
GR3003777T3 (es) | 1993-03-16 |
JPH0643426B2 (ja) | 1994-06-08 |
ATE71626T1 (de) | 1992-02-15 |
HU200458B (en) | 1990-06-28 |
AU598564B2 (en) | 1990-06-28 |
EP0254588A1 (en) | 1988-01-27 |
AU7562887A (en) | 1988-01-28 |
AR245718A1 (es) | 1994-02-28 |
JPS63146882A (ja) | 1988-06-18 |
EP0254588B1 (en) | 1992-01-15 |
HUT46000A (en) | 1988-09-28 |
KR880001651A (ko) | 1988-04-25 |
US4808596A (en) | 1989-02-28 |
DE3776018D1 (de) | 1992-02-27 |
CA1329204C (en) | 1994-05-03 |
KR940002824B1 (ko) | 1994-04-04 |
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