ES2051694T3 - Derivados de ergolina disustituidos en posiciones 1,2. - Google Patents

Derivados de ergolina disustituidos en posiciones 1,2.

Info

Publication number
ES2051694T3
ES2051694T3 ES86730153T ES86730153T ES2051694T3 ES 2051694 T3 ES2051694 T3 ES 2051694T3 ES 86730153 T ES86730153 T ES 86730153T ES 86730153 T ES86730153 T ES 86730153T ES 2051694 T3 ES2051694 T3 ES 2051694T3
Authority
ES
Spain
Prior art keywords
lower alkyl
optionally
substituted
group
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86730153T
Other languages
English (en)
Inventor
Andreas Dr Huth
Gerhard Dr Sauer
Helmut Dr Wachtel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2051694T3 publication Critical patent/ES2051694T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN DERIVADOS 1,2-DISUSTITUIDOS DE FORM. FIGXX EN LA CUAL X ES UN ATOMO DE OXIGENO O DE AZUFRE, R1 ES UN GRUPO ALQUILO INFERIOR R2 ES UN HALOGENO, UN GRUPO ACILO, UN GRUPO ALQUILO SATURADO O NO SATURADO QUE PUEDE ESTAR SUSTITUIDO CON OR4 (SIENDO R4 H, UN GRUPO ALQUILO INFERIOR, TETRAHIDROPIRANILO O CICLOALQUILO) O UN GRUPO ARILO SUSTITUIDO, O BIEN, UN GRUPO S-R5 EN EL QUE R5 REPRESENTA UN GRUPO ALQUILO INFERIOR QUE PUEDE ESTAR SUSTITUIDO, EN SU CASO, POR UN GRUPO ARILO, O BIEN, POR UN GRUPO ARILO SUSTITUIDO, O BIEN, EN GRUPO II SIENDO N=2, O, N=3, O BIEN, UN GRUPO -CHO. R3 ES UN GRUPO ALQUILO O ARILO INFERIOR Y C1-C10 REPRESENTA UN ENLACE C C SENCILLO O DOBLE Y EL ATOMO DE H SE ENCUENTRA SIEMPRE EN POSICION 10-ALFA SI EL ENLACE C9-C10 ES SENCILLO. SE DESCRIBEN ASIMISMO LAS SALES ACIDAS DE ADICION DE ESTOS DERIVADOS. ESTOS COMPUESTOS PRESENTAN VALIOSAS PROPIEDADES FARMACOLOGICAS.
ES86730153T 1985-10-04 1986-10-03 Derivados de ergolina disustituidos en posiciones 1,2. Expired - Lifetime ES2051694T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853535929 DE3535929A1 (de) 1985-10-04 1985-10-04 1,2-disubstituierte ergolinderivate

Publications (1)

Publication Number Publication Date
ES2051694T3 true ES2051694T3 (es) 1994-07-01

Family

ID=6283084

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86730153T Expired - Lifetime ES2051694T3 (es) 1985-10-04 1986-10-03 Derivados de ergolina disustituidos en posiciones 1,2.

Country Status (8)

Country Link
US (1) US4874768A (es)
EP (1) EP0217736B1 (es)
JP (1) JPH0670051B2 (es)
AT (1) ATE74919T1 (es)
CS (1) CS259893B2 (es)
DE (2) DE3535929A1 (es)
ES (1) ES2051694T3 (es)
GR (1) GR3005135T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3824659A1 (de) * 1988-07-15 1990-02-08 Schering Ag 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
WO1994014806A1 (en) * 1992-12-24 1994-07-07 Farmitalia Carlo Erba S.R.L. Serotoninergic ergoline derivatives
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
EP2067780A1 (en) * 2007-12-07 2009-06-10 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
JP6856532B2 (ja) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ エルゴリン化合物およびその使用
MX2019014272A (es) 2017-06-01 2020-12-11 Xoc Pharmaceuticals Inc Compuestos policiclicos y usos de los mismos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
DE3587860D1 (de) * 1984-04-09 1994-07-28 Schering Ag 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate

Also Published As

Publication number Publication date
DE3684855D1 (de) 1992-05-21
EP0217736B1 (de) 1992-04-15
ATE74919T1 (de) 1992-05-15
EP0217736A2 (de) 1987-04-08
DE3535929A1 (de) 1987-04-09
JPH0670051B2 (ja) 1994-09-07
GR3005135T3 (es) 1993-05-24
EP0217736A3 (en) 1989-03-22
JPS62174075A (ja) 1987-07-30
CS715486A2 (en) 1988-03-15
CS259893B2 (en) 1988-11-15
US4874768A (en) 1989-10-17

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