BE901987A - Derives d'alcanolamines et inhibiteurs de l'agregation des plaquettes en contenant comme principe actif. - Google Patents

Derives d'alcanolamines et inhibiteurs de l'agregation des plaquettes en contenant comme principe actif.

Info

Publication number
BE901987A
BE901987A BE0/214681A BE214681A BE901987A BE 901987 A BE901987 A BE 901987A BE 0/214681 A BE0/214681 A BE 0/214681A BE 214681 A BE214681 A BE 214681A BE 901987 A BE901987 A BE 901987A
Authority
BE
Belgium
Prior art keywords
hydrogen atom
fatty acid
platelet aggregation
inhibitors
active ingredient
Prior art date
Application number
BE0/214681A
Other languages
English (en)
Inventor
K Takahashi
Y Suwabe
Y Wakabayashi
Original Assignee
Terumo Kabashiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5379684A external-priority patent/JPS60197642A/ja
Priority claimed from JP2653385A external-priority patent/JPS61189252A/ja
Application filed by Terumo Kabashiki Kaisha filed Critical Terumo Kabashiki Kaisha
Publication of BE901987A publication Critical patent/BE901987A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés d'alcanolamines de la formule générale (I): où R1 représente un atome d'hydrogène ou un radical alcoyle inférieur, R2 représente un atome d'hydrogène ou un radical acyle issu de l'acide nicotinique, d'un acide gras supérieur triénique ou d'un acide gras supérieur pentaénique, R3 représente un atome d'hydrogène, un radical acyle issu de l'acide nicotinique, d'un acide gras supérieur triénique ou d'un acide gras supérieur pentaénique ou un radical 3-pyridylméthyle et n représente 2 ou 3, à l'exception des cas où R1 et R2 représentent chacun un atome d'hydrogène. Ces dérivés présentent une puissante activité inhibitrice de l'agrégation des plaquetes qui sont efficaces pour prévenir des affections telles que la thrombose. CD.CH.4
BE0/214681A 1984-03-21 1985-03-21 Derives d'alcanolamines et inhibiteurs de l'agregation des plaquettes en contenant comme principe actif. BE901987A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5379684A JPS60197642A (ja) 1984-03-21 1984-03-21 エタノ−ルアミン誘導体およびこれを有効成分として含有する血小板凝集抑制剤
JP2653385A JPS61189252A (ja) 1985-02-15 1985-02-15 アルカノ−ルアミン誘導体およびこれを有効成分として含有する血小板凝集抑制剤

Publications (1)

Publication Number Publication Date
BE901987A true BE901987A (fr) 1985-07-16

Family

ID=26364321

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214681A BE901987A (fr) 1984-03-21 1985-03-21 Derives d'alcanolamines et inhibiteurs de l'agregation des plaquettes en contenant comme principe actif.

Country Status (5)

Country Link
US (1) US4619938A (fr)
EP (1) EP0161422B1 (fr)
BE (1) BE901987A (fr)
DE (1) DE3568427D1 (fr)
IT (1) IT1185097B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2609026B1 (fr) * 1986-12-31 1989-03-31 Cird Amides de l'acide eicosatetraynoique et leur application en pharmacie et en cosmetique
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
IL103932A (en) * 1992-11-30 1997-02-18 Yissum Res & Dev Fatty acid and pharmaceutical compositions containing them
US5618955A (en) * 1992-11-30 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing same
MY118354A (en) 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
EP0823897B1 (fr) * 1995-05-01 2004-07-28 Scarista Limited Esters d'acide nicotinique et compositions pharmaceutiques contenant de tels esters
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
KR20060007385A (ko) * 2003-04-16 2006-01-24 교린 세이야꾸 가부시키 가이샤 경구 고형 제제
WO2009109973A2 (fr) * 2008-03-04 2009-09-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Composés et procédés pour le traitement de l’obésité
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
MX2012002710A (es) 2009-09-01 2012-04-19 Catabasis Pharmaceuticals Inc Conjugados de niacina y acidos grasos y sus usos.
CN103113253A (zh) * 2013-01-28 2013-05-22 国家海洋局第三海洋研究所 一种不饱和脂肪酸醇胺衍生物及其制备方法与应用
CN103833587B (zh) * 2014-03-26 2016-04-13 国家海洋局第三海洋研究所 一锅法制备高不饱和脂肪酰丙醇胺的方法
CN105230617B (zh) * 2015-09-25 2017-05-10 浙江大学 亚油酰乙醇胺在提高植物灰霉病和细菌性叶斑病抗性中的应用
CN105230616B (zh) * 2015-09-25 2017-05-10 浙江大学 廿二碳五烯酸乙醇胺在提高植物灰霉病抗性中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2304830A (en) * 1939-12-29 1942-12-15 Emulsol Corp Amides of heterocyclic carboxylic acids
CH441309A (de) * 1963-04-16 1967-08-15 Hoffmann La Roche Verfahren zur Herstellung von neuen Äthern
GB1089189A (en) * 1964-09-23 1967-11-01 Koninklijke Pharma Fab Nv Ethers of -(2-pyridyl)benzyl alcohols
CH464197A (de) * 1965-04-06 1968-10-31 Globopharm Ag Verfahren zur direkten Darstellung von freien Estern der B-Pyridincarbonsäure mit Aminoalkoholen
DE1806010A1 (de) * 1968-10-30 1970-05-21 Huels Chemische Werke Ag Verfahren zur Herstellung hellfarbiger Fettsaeureamidoaethylate
DE2129425C3 (de) * 1971-06-14 1975-05-22 Chemische Werke Huels Ag, 4370 Marl Verfahren zur Herstellung von Fettsäureäthanolamiden
HU165022B (fr) * 1972-04-28 1974-06-28
DE2461798A1 (de) * 1974-01-12 1975-07-17 Dainippon Pharmaceutical Co Neue alkylphosphorylamine, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
FR2346010A2 (fr) * 1976-03-29 1977-10-28 Fabre Sa Pierre Procede de preparation du chlorhydrate de n-nicotinoyl o-p-chloro phenoxy isobutanoyl ethanol amine, utile dans le traitement des dislipidemies et la prevention de l'atherosclerose
FR2392008A1 (fr) * 1977-05-02 1978-12-22 Fabre Sa Pierre Nouvelles formes modulees de medicaments utilisant les n-hydroxy alcoyl pyridine carboxamides comme vecteurs

Also Published As

Publication number Publication date
IT8519992A0 (it) 1985-03-21
US4619938A (en) 1986-10-28
DE3568427D1 (en) 1989-04-06
IT1185097B (it) 1987-11-04
EP0161422B1 (fr) 1989-03-01
EP0161422A1 (fr) 1985-11-21

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: TERUMO K.K.

Effective date: 19960331