HUP9902636A2 - NAALADáz inhibtor hatású foszfinil-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
NAALADáz inhibtor hatású foszfinil-származékok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9902636A2 HUP9902636A2 HU9902636A HUP9902636A HUP9902636A2 HU P9902636 A2 HUP9902636 A2 HU P9902636A2 HU 9902636 A HU9902636 A HU 9902636A HU P9902636 A HUP9902636 A HU P9902636A HU P9902636 A2 HUP9902636 A2 HU P9902636A2
- Authority
- HU
- Hungary
- Prior art keywords
- derivatives
- straight
- carbon atoms
- branched
- cycloalkenyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 hydroxyphosphinyl Chemical class 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 229940127422 Dipeptidase Inhibitors Drugs 0.000 abstract 1
- 102000003958 Glutamate Carboxypeptidase II Human genes 0.000 abstract 1
- 108090000369 Glutamate Carboxypeptidase II Proteins 0.000 abstract 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000008298 phosphoramidates Chemical class 0.000 abstract 1
- 208000017497 prostate disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány dipeptidázinhibitorokra, közelebbről az N-acetilezett a-helyzetben kapcsolódó savas dipeptidáz (NAALADase)-enzim hatását gátlóúj (I) általános képletű foszfonátszármazékokra, hidroxi-foszfinil-származékokra és foszforamidát-származékokra - ahol a képletben R1 jelentése hidrogénatom, 1-9 szénatomos egyenes vagy elágazó láncúalkil-, 2-9 szénatomos egyenes vagy elágazó láncú alkenil-, 3-8szénatomos cikloalkil-, 5-7 szénatomos cikloalkenilcsoport vagy Ar1csoport; X jelentése oxigénatom, -CH2- vagy =NR1 csoport, ahol R1 jelentése a fent megadott; és R2 jelentése 1-9 szénatomos egyenes vagy elágazó láncú alkil-, 2-9szénatomos egyenes vagy elágazó láncú alkenil-, 3-8 szénatomoscikloalkil-, 5-7 szénatomos cikloalkenilcsoport vagy Ar1 csoport, aholaz alkil-, alkenil-, cikloalkil-, cikloalkenil- vagy arilcsoport adottesetben helyettesítve van -, ezeket tartalmazó, prosztatabetegségekellen hatásos gyógyszerkészítményekre, továbbá a fenti származékokNAALADáz-enzim-aktivitást gátló hatású gyógyszerkészítményekelőállításában történő alkalmazására vonatkozik. Ó
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/665,776 US5672592A (en) | 1996-06-17 | 1996-06-17 | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
US08/775,586 US5795877A (en) | 1996-12-31 | 1996-12-31 | Inhibitors of NAALADase enzyme activity |
US08/778,733 US5863536A (en) | 1996-12-31 | 1996-12-31 | Phosphoramidate derivatives |
US08/858,985 US6025344A (en) | 1996-06-17 | 1997-05-27 | Certain dioic acid derivatives useful as NAALADase inhibitors |
PCT/US1997/011538 WO1997048399A1 (en) | 1996-06-17 | 1997-06-16 | Certain phosphinyl derivatives useful as naaladase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP9902636A2 true HUP9902636A2 (hu) | 2001-04-28 |
Family
ID=27505321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902636A HUP9902636A2 (hu) | 1996-06-17 | 1997-06-16 | NAALADáz inhibtor hatású foszfinil-származékok és ezeket tartalmazó gyógyszerkészítmények |
Country Status (15)
Country | Link |
---|---|
US (2) | US6025344A (hu) |
EP (1) | EP0957924A4 (hu) |
JP (1) | JP2002514157A (hu) |
KR (1) | KR20000016749A (hu) |
AU (1) | AU726854B2 (hu) |
CA (1) | CA2258589A1 (hu) |
CZ (1) | CZ390098A3 (hu) |
HU (1) | HUP9902636A2 (hu) |
IL (1) | IL127257A0 (hu) |
LV (1) | LV12232B (hu) |
NO (1) | NO985874L (hu) |
NZ (1) | NZ333234A (hu) |
PL (1) | PL330409A1 (hu) |
TR (1) | TR199802637T2 (hu) |
WO (1) | WO1997048399A1 (hu) |
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US20040253246A1 (en) * | 1996-02-23 | 2004-12-16 | Israeli Ron S. | Prostate-specific membrane antigen and uses thereof |
US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
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US6054444A (en) * | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
NZ333235A (en) * | 1996-06-17 | 2000-06-23 | Guilford Pharm Inc | Methods of cancer treatment using naaladase inhibitors |
US5977090A (en) * | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
US6121252A (en) * | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
ES2251204T3 (es) * | 1998-07-06 | 2006-04-16 | Mgi Gp, Inc. | Inhibidores de naaladasa utiles como compuestos y composiciones farmaceuticas. |
US6395718B1 (en) * | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
JP5095050B2 (ja) | 1999-04-28 | 2012-12-12 | ジョージタウン ユニバーシティー | 代謝調節型グルタミン酸受容体のリガンド、及び、NAALADaseの阻害剤 |
US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
US6228888B1 (en) | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
CA2410889A1 (en) * | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating retinal disorders and glaucoma |
AU2001265111A1 (en) | 2000-05-30 | 2001-12-11 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
DE60214134T2 (de) * | 2001-02-07 | 2007-07-19 | Beth Israel Deaconess Medical Center, Boston | Modifizierte psma-liganden und deren verwendung |
US20030013635A1 (en) * | 2001-04-11 | 2003-01-16 | Meyerhoff James L. | Method for the treatment of depression by inhibition of NAALADase |
AU2002310202B2 (en) * | 2001-05-30 | 2008-05-15 | Eisai Inc. | Thiolalkyl benzoic acid derivatives |
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PT1599461E (pt) * | 2003-03-03 | 2009-07-20 | Eisai Corp North America | Tiolactonas como inibidores de naaladase |
GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
ES2354338T3 (es) * | 2004-09-17 | 2011-03-14 | Idenix Pharmaceuticals, Inc. | Fosfoindoles como inhibidores de vih. |
RS50981B (sr) * | 2004-09-17 | 2010-10-31 | Idenix Pharmaceuticals Inc. | Fosfoindoli kao hiv inhibitori |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
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SI2097111T1 (sl) | 2006-11-08 | 2016-02-29 | Molecular Insight Pharmaceuticals, Inc. | Heterodimeri glutaminske kisline |
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-
1997
- 1997-05-27 US US08/858,985 patent/US6025344A/en not_active Expired - Fee Related
- 1997-06-16 NZ NZ333234A patent/NZ333234A/xx not_active IP Right Cessation
- 1997-06-16 JP JP50190298A patent/JP2002514157A/ja active Pending
- 1997-06-16 WO PCT/US1997/011538 patent/WO1997048399A1/en not_active Application Discontinuation
- 1997-06-16 CZ CZ983900A patent/CZ390098A3/cs unknown
- 1997-06-16 IL IL12725797A patent/IL127257A0/xx unknown
- 1997-06-16 CA CA002258589A patent/CA2258589A1/en not_active Abandoned
- 1997-06-16 PL PL97330409A patent/PL330409A1/xx unknown
- 1997-06-16 HU HU9902636A patent/HUP9902636A2/hu unknown
- 1997-06-16 TR TR1998/02637T patent/TR199802637T2/xx unknown
- 1997-06-16 AU AU35906/97A patent/AU726854B2/en not_active Ceased
- 1997-06-16 KR KR1019980710356A patent/KR20000016749A/ko not_active Application Discontinuation
- 1997-06-16 EP EP97932448A patent/EP0957924A4/en not_active Withdrawn
-
1998
- 1998-12-15 NO NO985874A patent/NO985874L/no unknown
- 1998-12-15 LV LVP-98-278A patent/LV12232B/en unknown
-
1999
- 1999-12-17 US US09/466,059 patent/US6479471B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL330409A1 (en) | 1999-05-10 |
WO1997048399A1 (en) | 1997-12-24 |
US6025344A (en) | 2000-02-15 |
JP2002514157A (ja) | 2002-05-14 |
LV12232A (lv) | 1999-03-20 |
US6479471B1 (en) | 2002-11-12 |
EP0957924A4 (en) | 2000-04-12 |
NO985874L (no) | 1999-02-15 |
AU726854B2 (en) | 2000-11-23 |
CA2258589A1 (en) | 1997-12-24 |
TR199802637T2 (xx) | 1999-03-22 |
EP0957924A1 (en) | 1999-11-24 |
AU3590697A (en) | 1998-01-07 |
KR20000016749A (ko) | 2000-03-25 |
LV12232B (en) | 1999-08-20 |
CZ390098A3 (cs) | 1999-05-12 |
NO985874D0 (no) | 1998-12-15 |
IL127257A0 (en) | 1999-09-22 |
NZ333234A (en) | 1999-07-29 |
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