TNSN86144A1 - Procede pour la preparation de derives de la flavone - Google Patents
Procede pour la preparation de derives de la flavoneInfo
- Publication number
- TNSN86144A1 TNSN86144A1 TNTNSN86144A TNSN86144A TNSN86144A1 TN SN86144 A1 TNSN86144 A1 TN SN86144A1 TN TNSN86144 A TNTNSN86144 A TN TNSN86144A TN SN86144 A TNSN86144 A TN SN86144A TN SN86144 A1 TNSN86144 A1 TN SN86144A1
- Authority
- TN
- Tunisia
- Prior art keywords
- carbon atoms
- alkyl
- different
- phenyl
- general formula
- Prior art date
Links
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N flavone Chemical class O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 6
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- -1 3,3- DIPHENYLPROPYL Chemical class 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002212 flavone derivatives Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
PROCEDE POUR LA PREPARTION DE NOUVEAUX DERIVES DE LA FLAVONE DE FORMULE GENERALE (I) DANS LESQUELS R ET R1 PEUVENT ETRE EGAUX OU DIFFERENTS ET SONT UN ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE, HYDROXY ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE, FORMYLALKYLE OU CYANOALKYLE, R2 ET R3 PEUVENT ETRE EGAUX OU DIFFERENTS ET SONT UN ALKYLE LINEAIRE OU RAMIFIE CONTENANT 1 A 6 ATOMES DE CARBONE, ALKENYLE LINEAIRE OU RAMIFIE CONTENANT 2 A 6 ATOMES DE CARBONE, ALKYNYLE CONTENANT 2 A 6 ATOMES DE CARBONE, CYCLOALKYLE AYANT 5 A 7 ATOMES DE CARBONE, ARALKYLE, PHENYLE, CYANOALKYLE, HALOALKYLE, MONO- OU POLY- HYDROXYALKYLE, ALKOXYALKYLE, ALKYLTHIOALKYLE, ALKYLSULFONYLALKYLE, ACYLOXYALKYLE, ACYLALKYLE, R4R5N-ALKYLE LINEAIRE OU RAMIFIE AYANT 2 A 6 ATOMES DE CARBONE, OU R4 ET R5 SONT EGAUX OU DIFFERENTS ET SONT HYDROGENE, ALKYLE, CYCLOALKYLE, ARALKYLE, PHENYLE, 3,3- DIPHENYLPROPYLE, OU EN ALTERNATIVE, ENSEMBLE AVEC L'ATOME D'HYROGENE, ILS FORMENT UNE CHAINE DE 4 A 7 ELEMENTS SATUREE OU NON SATUREE, CONTENANT D'AUTRES HETEROATOMES TELS QUE O, N OU LE GROUPE NR6 OU R6 EST UN ALKYLE, LEURS ISOMERES OPTIQUES ET DIASTEREOISOMERES, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES. LES COMPOSES DE FORMULE GENERALE (I) MONTRENT UNE ACTIVITE CALCIUM-ANTAGONISTE ET/OU UNE ACTIVITE DE RELACHEMENT SUR LA MUSCULATURE LISSE (NOTAMMENT SUR LA VESSIE)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22578/85A IT1190405B (it) | 1985-10-22 | 1985-10-22 | Derivati del flavone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN86144A1 true TNSN86144A1 (fr) | 1990-01-01 |
Family
ID=11198039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN86144A TNSN86144A1 (fr) | 1985-10-22 | 1986-10-21 | Procede pour la preparation de derives de la flavone |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4806534A (fr) |
| EP (1) | EP0223744B1 (fr) |
| JP (1) | JPH0772186B2 (fr) |
| KR (1) | KR910009269B1 (fr) |
| CN (1) | CN86107544A (fr) |
| AR (1) | AR243883A1 (fr) |
| AT (1) | ATE73453T1 (fr) |
| AU (1) | AU596382B2 (fr) |
| CA (1) | CA1330994C (fr) |
| DE (1) | DE3684244D1 (fr) |
| DK (1) | DK169408B1 (fr) |
| EG (1) | EG18109A (fr) |
| ES (1) | ES2002425A6 (fr) |
| FI (1) | FI89167C (fr) |
| GR (1) | GR862546B (fr) |
| HU (1) | HU202863B (fr) |
| IE (1) | IE58330B1 (fr) |
| IL (1) | IL80229A0 (fr) |
| IT (1) | IT1190405B (fr) |
| NO (1) | NO167570C (fr) |
| NZ (1) | NZ217964A (fr) |
| PH (1) | PH22766A (fr) |
| PT (1) | PT83604B (fr) |
| SG (1) | SG55192G (fr) |
| TN (1) | TNSN86144A1 (fr) |
| ZA (1) | ZA867941B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912223A (en) * | 1988-01-28 | 1990-03-27 | Nelson Research & Development Co. | 1,4-Dihydropyridines |
| US5580751A (en) * | 1990-09-14 | 1996-12-03 | Carlsberg A/S | Process for the preparation of C-terminally amidated peptides |
| US5244602A (en) * | 1990-12-03 | 1993-09-14 | Ppg Industries, Inc. | Photochromic naphthopyrans |
| DE4321030A1 (de) * | 1993-06-24 | 1995-01-05 | Bayer Ag | 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel |
| SE9703377D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| KR100392468B1 (ko) * | 2000-09-18 | 2003-07-22 | 주식회사 엘지생명과학 | 사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체 |
| JP4280067B2 (ja) | 2001-01-16 | 2009-06-17 | アストラゼネカ・アクチエボラーグ | 治療用ヘテロ環式化合物 |
| DE102005034264A1 (de) | 2005-07-22 | 2007-02-01 | Bayer Healthcare Ag | 4-Chromenonyl-1,4-dihydropyridincarbonitrile und ihre Verwendung |
| DE102005034267A1 (de) * | 2005-07-22 | 2007-01-25 | Bayer Healthcare Ag | 4-Chromenonyl-1,4-dihydropyridine und ihre Verwendung |
| CN103254122B (zh) * | 2013-06-19 | 2015-04-22 | 湖南师范大学 | 一种心血管药物尼伐地平的制备方法 |
| AR121719A1 (es) | 2020-04-03 | 2022-06-29 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| CR20230517A (es) | 2021-05-03 | 2023-11-28 | Petra Pharma Corp | Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades |
| BR112023022890A2 (pt) | 2021-05-27 | 2024-01-23 | Petra Pharma Corp | Inibidores de cromenona alostéricos de fosfoinositídio 3-cinase (pi3k), composições farmacêuticas que os compreendem e usos dos mesmos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2921070A (en) * | 1957-11-05 | 1960-01-12 | Recordati Lab Farmacologico S | Basic esters of 3-methylflavone-8-carboxylic acid |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3311005A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
-
1985
- 1985-10-22 IT IT22578/85A patent/IT1190405B/it active
-
1986
- 1986-10-03 IL IL80229A patent/IL80229A0/xx not_active IP Right Cessation
- 1986-10-14 GR GR862546A patent/GR862546B/el unknown
- 1986-10-15 NO NO864108A patent/NO167570C/no unknown
- 1986-10-15 AR AR86305576A patent/AR243883A1/es active
- 1986-10-16 NZ NZ217964A patent/NZ217964A/en unknown
- 1986-10-20 DE DE8686830300T patent/DE3684244D1/de not_active Expired - Fee Related
- 1986-10-20 ZA ZA867941A patent/ZA867941B/xx unknown
- 1986-10-20 AT AT86830300T patent/ATE73453T1/de not_active IP Right Cessation
- 1986-10-20 ES ES8602677A patent/ES2002425A6/es not_active Expired
- 1986-10-20 EP EP86830300A patent/EP0223744B1/fr not_active Expired - Lifetime
- 1986-10-21 TN TNTNSN86144A patent/TNSN86144A1/fr unknown
- 1986-10-21 FI FI864260A patent/FI89167C/fi not_active IP Right Cessation
- 1986-10-21 HU HU864363A patent/HU202863B/hu not_active IP Right Cessation
- 1986-10-21 JP JP61251553A patent/JPH0772186B2/ja not_active Expired - Lifetime
- 1986-10-21 CA CA000520953A patent/CA1330994C/fr not_active Expired - Fee Related
- 1986-10-21 IE IE276886A patent/IE58330B1/en not_active IP Right Cessation
- 1986-10-22 PT PT83604A patent/PT83604B/pt not_active IP Right Cessation
- 1986-10-22 AU AU64273/86A patent/AU596382B2/en not_active Ceased
- 1986-10-22 CN CN198686107544A patent/CN86107544A/zh active Pending
- 1986-10-22 PH PH34400A patent/PH22766A/en unknown
- 1986-10-22 KR KR1019860008836A patent/KR910009269B1/ko not_active IP Right Cessation
- 1986-10-22 DK DK506386A patent/DK169408B1/da not_active IP Right Cessation
- 1986-10-22 US US06/921,397 patent/US4806534A/en not_active Expired - Fee Related
- 1986-10-22 EG EG662/86A patent/EG18109A/xx active
-
1992
- 1992-05-23 SG SG551/92A patent/SG55192G/en unknown
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