FR2408584A1 - Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation - Google Patents

Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation

Info

Publication number
FR2408584A1
FR2408584A1 FR7831718A FR7831718A FR2408584A1 FR 2408584 A1 FR2408584 A1 FR 2408584A1 FR 7831718 A FR7831718 A FR 7831718A FR 7831718 A FR7831718 A FR 7831718A FR 2408584 A1 FR2408584 A1 FR 2408584A1
Authority
FR
France
Prior art keywords
compounds
antifibrinolysin
guanidinobenzoic
preparation process
antitrypsin activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7831718A
Other languages
English (en)
Other versions
FR2408584B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of FR2408584A1 publication Critical patent/FR2408584A1/fr
Application granted granted Critical
Publication of FR2408584B1 publication Critical patent/FR2408584B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES GUANIDINOBENZOIQUES ET UN PROCEDE DE LEUR PREPARATION. LES COMPOSES DE L'INVENTION REPONDENT A LA FORMULE (I) (CF DESSIN DANS BOPI) OU Z REPRESENTE UN RADICAL METHYLENE, ETHYLENE OU VINYLENE ET R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE INFERIEUR ET LEURS SELS D'ADDITION D'ACIDES; UN PROCEDE DE PREPARATION DE CES COMPOSES EST EGALEMENT DECRIT. LES COMPOSES DE L'INVENTION SONT DES MEDICAMENTS UTILES NOTAMMENT COMME ANTIFIBRINOLYSINE ET ANTITRYPSINE.
FR7831718A 1977-11-09 1978-11-09 Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation Granted FR2408584A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13337977A JPS5470241A (en) 1977-11-09 1977-11-09 Guanidinobenzoic acid derivative and its preparation

Publications (2)

Publication Number Publication Date
FR2408584A1 true FR2408584A1 (fr) 1979-06-08
FR2408584B1 FR2408584B1 (fr) 1983-12-09

Family

ID=15103351

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7831718A Granted FR2408584A1 (fr) 1977-11-09 1978-11-09 Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation

Country Status (5)

Country Link
US (1) US4224342A (fr)
JP (1) JPS5470241A (fr)
DE (1) DE2846251A1 (fr)
FR (1) FR2408584A1 (fr)
GB (1) GB2007653B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2044760B (en) 1979-03-01 1983-03-23 Ono Pharmaceutical Co Guanidinobenzoic acid derivatives
US4490388A (en) * 1981-02-27 1984-12-25 Torii & Co., Ltd. Amidine compound and anticomplement agent comprising same
US4423069A (en) * 1982-01-20 1983-12-27 University Of Illinois Foundation Contraceptive method
JPS6254A (ja) * 1985-03-08 1987-01-06 Kanebo Ltd 新規グアニジノメチルシクロヘキサンカルボン酸誘導体および該化合物を有効成分とする抗潰瘍薬
US4843094A (en) * 1985-11-12 1989-06-27 Ono Pharmaceutical Co., Ltd. Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient
DE3681408D1 (fr) * 1985-11-12 1991-10-17 Ono Pharmaceutical Co. Ltd., Osaka, Jp
US5247084A (en) * 1985-11-12 1993-09-21 Ono Pharmaceutical Co., Ltd. Derivatives of p-guanidinobenzoic acid
JPH0676373B2 (ja) * 1985-12-27 1994-09-28 エーザイ株式会社 グアニジノ安息香酸エステル誘導体
KR20000005312A (ko) 1996-04-10 2000-01-25 오노 야꾸힝 고교 가부시키가이샤 트립타아제 억제제 및 신규 구아니디노 유도체
US6066673A (en) * 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
WO2000051625A1 (fr) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibiteurs d'activite de serine protease, methodes et compositions de traitement de virus de l'herpes
US6489308B1 (en) 1999-03-05 2002-12-03 Trustees Of University Of Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
PL2520654T3 (pl) * 2003-08-26 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
CA2839917A1 (fr) 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, procedes et utilisations de molecules de fusion de l'alpha-1 antitrypsine
AU2013202648B2 (en) 2012-01-10 2016-05-19 Konkuk University Compositions, methods and uses for alpha-1 antitrypsin fusion molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
FR2289181A1 (fr) * 1974-11-01 1976-05-28 Ono Pharmaceutical Co Nouveaux derives d'acide guanidinobenzoique et composes et procedes pour leur preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5440534B2 (fr) * 1972-05-12 1979-12-04
JPS5116631A (ja) * 1974-07-31 1976-02-10 Ono Pharmaceutical Co Guanijinoansokukosanjudotaino seizohoho

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
FR2289181A1 (fr) * 1974-11-01 1976-05-28 Ono Pharmaceutical Co Nouveaux derives d'acide guanidinobenzoique et composes et procedes pour leur preparation

Also Published As

Publication number Publication date
GB2007653B (en) 1982-04-07
JPS5735870B2 (fr) 1982-07-31
JPS5470241A (en) 1979-06-05
DE2846251C2 (fr) 1988-08-04
FR2408584B1 (fr) 1983-12-09
US4224342A (en) 1980-09-23
DE2846251A1 (de) 1979-05-10
GB2007653A (en) 1979-05-23

Similar Documents

Publication Publication Date Title
FR2408584A1 (fr) Composes guanidinobenzoiques et possedant une activite antifibrinolysine et antitrypsine et leur procede de preparation
FR2414039A1 (fr) Derives de prostacycline, leur procede de preparation et leurs applications en therapeutique
FR2603584A1 (fr) Nouveaux composes benzoheterocycliques utiles comme agents antimicrobiens, procede pour leur preparation et medicament les contenant
FR2372818A1 (fr) Acide 5-(hydroxy (substitue) methyl)-2,3-dihydrobenzofuran-2-carboxylique et ses derives utiles comme medicaments
FR2450820A1 (fr) Nouveaux derives d'acides 1- (o-mercaptoacyl) -4,5-dihydropyrazole-5-carboxyliques, utiles notamment comme agents hypotenseurs, et leur procede de preparation
FR2412535A1 (fr) Ethers imidazolylvinyliques et produits fongicides qui en contiennent
PT87277A (pt) Process for the preparation of new bicyclic compounds and pharmaceutical compositions comprising same
FR2355797A1 (fr) Procede de preparation de vinylcyclopropanes substitues utilisables dans la preparation d'insecticides
FR2407928A1 (fr) Derives de quinazoline utiles comme medicaments antihypertenseurs et procede de leur preparation
FR2445318A1 (fr) Procede de preparation de 1-(3-mercapto-propanoyl)-l-prolines
HU903092D0 (en) Process for the preparation of buten-carboxylic acid derivatives and pharmaceutical compositions containing such compounds
FR2447375A1 (fr) Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant
FR2354339A1 (fr) Procede de preparation d'acides 1-aminoalcane-1,1-diphosphoniques
FR2411173A1 (fr) Anthranilates de n-hydroxyalkyl-carboxamides et leur application comme reticulants
FR2413358A1 (fr) Nouveaux derives de 2-aminomethylphenol, utiles notamment comme agents anti-inflammatoires, et leur procede de preparation
FR2387996A1 (fr) Procede de preparation de l'auranofine
ES8100249A1 (es) Un metodo para la preparacion de un compuesto de acido hi- droxamico
ATE123487T1 (de) Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen.
FR2383177A1 (fr) Procede de preparation de derives de 2,1,3-thiadiazine-4-one-2,2-dioxyde
FR2366298A1 (fr) Procede de preparation de derives de rifamycine p et q
FR2411182A1 (fr) Esters anthraniliques d'acides cyanuriques alcoxyles, utilisables comme allongeurs de chaines ou comme reticulants
FR2368495A1 (fr) Procede de preparation d'acides 2-carbamoylphosphiniques n-substitues
FR2434807A1 (fr) Procede perfectionne de preparation d'hydroxymethyl-4(5) alkyl inferieur-5 (4)-imidazoles et de leurs sels d'addition d'acide
FR2407935A1 (fr) 4-desacetoxy-4a-hydroxyindole-dihydroindoles dimeres et leur utilisation therapeutique
FR2385723A1 (fr) Procede d'epimerisation d'une thiazolidine-azetidinone

Legal Events

Date Code Title Description
ST Notification of lapse