ES2004141A6 - Un procedimiento de preparacion de nuevas 1,4-dihidropiridinas - Google Patents
Un procedimiento de preparacion de nuevas 1,4-dihidropiridinasInfo
- Publication number
- ES2004141A6 ES2004141A6 ES8701462A ES8701462A ES2004141A6 ES 2004141 A6 ES2004141 A6 ES 2004141A6 ES 8701462 A ES8701462 A ES 8701462A ES 8701462 A ES8701462 A ES 8701462A ES 2004141 A6 ES2004141 A6 ES 2004141A6
- Authority
- ES
- Spain
- Prior art keywords
- dihydropyridines
- processes
- preparation
- antithrombotic drugs
- saturated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE NUEVAS 1,4©DIHIDROPIRIDINAS UTILES COMO MEDICAMENTOS ANTITROMBOTICOS. DICHAS NUEVAS 1,4©DIHIDROPIRIDINAS TIENEN LA SIGUIENTE FORMULA GENERAL (I) EN LA CUAL R REPRESENTA HIDROGENO O UN GRUPO ALQUILO SATURADO O INSATURADO DE CADENA LINEAL O RAMIFICADA DE 1 A 8 ATOMOS DE CARBONO, R1 REPRESENTA UN RADICAL ALQUILICO DE CADENA LINEAL, RAMIFICADA O CICLICA, SATURADA O INSATURADA DE 1 A 12 ATOMOS DE CARBONO QUE PUEDE ESTAR INTERRUMPIDA POR UN ATOMO DE OXIGENO O POR UN GRUPO 2©(N©SALICILAMIDO)ETILO, N ES UN NUMERO IGUAL A 1 O
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863617976 DE3617976A1 (de) | 1986-05-28 | 1986-05-28 | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2004141A6 true ES2004141A6 (es) | 1988-12-01 |
Family
ID=6301807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8701462A Expired ES2004141A6 (es) | 1986-05-28 | 1987-05-18 | Un procedimiento de preparacion de nuevas 1,4-dihidropiridinas |
Country Status (12)
Country | Link |
---|---|
US (1) | US4782069A (es) |
EP (1) | EP0253092B1 (es) |
JP (1) | JPS62289578A (es) |
AR (1) | AR243185A1 (es) |
AT (1) | AT395011B (es) |
CA (1) | CA1311481C (es) |
DE (1) | DE3617976A1 (es) |
ES (1) | ES2004141A6 (es) |
GR (1) | GR870824B (es) |
MX (1) | MX163341A (es) |
PT (1) | PT84959B (es) |
ZA (1) | ZA873778B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4003541C1 (es) * | 1990-02-06 | 1991-08-08 | Alter S.A., Madrid, Es | |
US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
AU668694B2 (en) * | 1991-12-19 | 1996-05-16 | Sanofi-Synthelabo | Saccharin derivative proteolytic enzyme inhibitors |
AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
TW226016B (es) * | 1991-12-30 | 1994-07-01 | Sterling Winthrop Inc | |
WO1995014018A1 (es) * | 1993-11-19 | 1995-05-26 | Laboratorios Alter, S.A. | Nuevos derivados de 1,4-dihidropiridina, procedimiento para su fabricacion y uso como agentes terapeuticos |
EP0771560A1 (en) * | 1995-08-25 | 1997-05-07 | Laboratorios Alter, S.A. | Use of 2- N-(1,2-benzoisothiazolyl-3(2H)one-1,1-dioxide ethyl 5-ethoxycarbonyl-2,4,6-trimethyl-1,4-dihydropiridine-3-carboxylate in the treatment of vascular disorders |
MX2022000133A (es) | 2019-07-01 | 2022-04-27 | Tonix Pharma Ltd | Anticuerpos anti-cd154 y usos de los mismos. |
US20240059781A1 (en) | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ182325A (en) * | 1975-11-18 | 1979-03-16 | Beecham Group Ltd | 2-substituted-1,2-benzisothiazol-3-ones |
EP0000254B1 (en) * | 1977-06-20 | 1981-06-10 | Beecham Group Plc | Antithrombotic 2-(gamma-(1-piperidinyl)propyl)1,2-benzisothiazol 3-one, its pharmaceutically acceptable acid addition salts, their preparation and their compositions |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
DE3420784A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
JPS6143165A (ja) * | 1984-08-07 | 1986-03-01 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体の製造法 |
GR851819B (es) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
US4757071A (en) * | 1984-12-14 | 1988-07-12 | Nisshin Flour Milling Co., Ltd. | 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases |
-
1986
- 1986-05-28 DE DE19863617976 patent/DE3617976A1/de active Granted
-
1987
- 1987-05-14 EP EP87107008A patent/EP0253092B1/en not_active Expired - Lifetime
- 1987-05-18 ES ES8701462A patent/ES2004141A6/es not_active Expired
- 1987-05-18 US US07/051,852 patent/US4782069A/en not_active Expired - Fee Related
- 1987-05-21 MX MX6578A patent/MX163341A/es unknown
- 1987-05-25 GR GR870824A patent/GR870824B/el unknown
- 1987-05-25 CA CA000537913A patent/CA1311481C/en not_active Expired - Fee Related
- 1987-05-26 AR AR87307647A patent/AR243185A1/es active
- 1987-05-26 ZA ZA873778A patent/ZA873778B/xx unknown
- 1987-05-27 PT PT84959A patent/PT84959B/pt not_active IP Right Cessation
- 1987-05-27 AT AT0135687A patent/AT395011B/de not_active IP Right Cessation
- 1987-05-28 JP JP62133243A patent/JPS62289578A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
AT395011B (de) | 1992-08-25 |
PT84959B (pt) | 1990-02-08 |
AR243185A1 (es) | 1993-07-30 |
EP0253092A1 (en) | 1988-01-20 |
EP0253092B1 (en) | 1991-09-25 |
DE3617976C2 (es) | 1989-05-03 |
PT84959A (en) | 1987-06-01 |
ZA873778B (en) | 1987-11-20 |
JPS62289578A (ja) | 1987-12-16 |
MX163341A (es) | 1992-04-24 |
JPH0411547B2 (es) | 1992-02-28 |
DE3617976A1 (de) | 1988-01-14 |
GR870824B (en) | 1987-09-30 |
ATA135687A (de) | 1992-01-15 |
US4782069A (en) | 1988-11-01 |
CA1311481C (en) | 1992-12-15 |
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