ZA873778B - 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs - Google Patents

1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs

Info

Publication number
ZA873778B
ZA873778B ZA873778A ZA873778A ZA873778B ZA 873778 B ZA873778 B ZA 873778B ZA 873778 A ZA873778 A ZA 873778A ZA 873778 A ZA873778 A ZA 873778A ZA 873778 B ZA873778 B ZA 873778B
Authority
ZA
South Africa
Prior art keywords
dihydropyridines
obtention
processes
antithrombotic drugs
antithrombotic
Prior art date
Application number
ZA873778A
Other languages
English (en)
Inventor
Sunkel Carlos
Fau De Casa-Juana Miguel
Dorrego Fernando
Priego Jaime
Ortega Pilar
Cillero Javier
Original Assignee
Alter, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alter, S.A. filed Critical Alter, S.A.
Publication of ZA873778B publication Critical patent/ZA873778B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA873778A 1986-05-28 1987-05-26 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs ZA873778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863617976 DE3617976A1 (de) 1986-05-28 1986-05-28 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten

Publications (1)

Publication Number Publication Date
ZA873778B true ZA873778B (en) 1987-11-20

Family

ID=6301807

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA873778A ZA873778B (en) 1986-05-28 1987-05-26 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs

Country Status (12)

Country Link
US (1) US4782069A (xx)
EP (1) EP0253092B1 (xx)
JP (1) JPS62289578A (xx)
AR (1) AR243185A1 (xx)
AT (1) AT395011B (xx)
CA (1) CA1311481C (xx)
DE (1) DE3617976A1 (xx)
ES (1) ES2004141A6 (xx)
GR (1) GR870824B (xx)
MX (1) MX163341A (xx)
PT (1) PT84959B (xx)
ZA (1) ZA873778B (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4003541C1 (xx) * 1990-02-06 1991-08-08 Alter S.A., Madrid, Es
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
AU668694B2 (en) * 1991-12-19 1996-05-16 Sanofi-Synthelabo Saccharin derivative proteolytic enzyme inhibitors
US5378720A (en) * 1991-12-19 1995-01-03 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
TW226016B (xx) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
WO1995014018A1 (es) * 1993-11-19 1995-05-26 Laboratorios Alter, S.A. Nuevos derivados de 1,4-dihidropiridina, procedimiento para su fabricacion y uso como agentes terapeuticos
EP0771560A1 (en) * 1995-08-25 1997-05-07 Laboratorios Alter, S.A. Use of 2- N-(1,2-benzoisothiazolyl-3(2H)one-1,1-dioxide ethyl 5-ethoxycarbonyl-2,4,6-trimethyl-1,4-dihydropiridine-3-carboxylate in the treatment of vascular disorders
CN114423785A (zh) 2019-07-01 2022-04-29 通尼克斯制药有限公司 抗-cd154抗体及其用途
MX2023008055A (es) 2021-01-06 2023-08-22 Tonix Pharma Ltd Métodos para inducir tolerancia inmune con anticuerpos anti-cd154 modificados.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ182325A (en) * 1975-11-18 1979-03-16 Beecham Group Ltd 2-substituted-1,2-benzisothiazol-3-ones
DE2860750D1 (en) * 1977-06-20 1981-09-17 Beecham Group Plc Antithrombotic 2-(gamma-(1-piperidinyl)propyl)1,2-benzisothiazol 3-one, its pharmaceutically acceptable acid addition salts, their preparation and their compositions
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
AU561213B2 (en) * 1983-06-02 1987-04-30 Teijin Limited 1, 4-dihydropyridine derivative
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
DE3420784A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
GR851819B (xx) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases

Also Published As

Publication number Publication date
AR243185A1 (es) 1993-07-30
GR870824B (en) 1987-09-30
PT84959A (en) 1987-06-01
AT395011B (de) 1992-08-25
EP0253092A1 (en) 1988-01-20
JPS62289578A (ja) 1987-12-16
DE3617976C2 (xx) 1989-05-03
US4782069A (en) 1988-11-01
DE3617976A1 (de) 1988-01-14
PT84959B (pt) 1990-02-08
EP0253092B1 (en) 1991-09-25
ES2004141A6 (es) 1988-12-01
ATA135687A (de) 1992-01-15
MX163341A (es) 1992-04-24
CA1311481C (en) 1992-12-15
JPH0411547B2 (xx) 1992-02-28

Similar Documents

Publication Publication Date Title
IL82671A0 (en) 1,5-diaryl-3-substituted-pyrazoles,their preparation and pharmaceutical compositions containing them
IL81672A0 (en) N,n'-dihalo-2-imidazolidinones and their use as disinfectants
IL81793A (en) C(29)-acyloxy-milbemycin derivatives,their preparation and their use as pesticides
IL83034A (en) Alpha-aryl-alpha-phenylethyl-1h-1,2,4-triazole-1-propanenitriles,their preparation and their use as fungicides
GB2194237B (en) 1,2,2,6, 6-pentamethyl-4-piperidylaminotriazine derivatives and their use as stabilizers
ZA87327B (en) 1,4-dihydropyridines
IL84832A0 (en) 6-benzoxazinyl-and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones,their preparation and pharmaceutical compositions containing them
IL82687A0 (en) 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives,their preparation and their use as pesticides
AR244674A1 (es) Procedimiento para preparar derivados de acidos 3,4-dihidro-3-tioxo-2h-1,4-bensoxa (o tia)zin-4-aceticos.
IL81209A (en) Substituted 6h-indolo(2,3-b)-quinoxalines,their preparation and pharmaceutical compositions comprising them
IL82242A0 (en) N-substituted-n'-substituted-n,n'-diacylhydrazines and their use as insecticides
IL83413A0 (en) 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
ZA873778B (en) 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs
EP0260121A3 (en) Inosose derivatives, production and use thereof
GR3003110T3 (en) Inosose derivatives and production thereof
PH24239A (en) New 4-pyridone derivatives,their pharmaceutical compositions and use
EP0264091A3 (en) 3-propenylcephem derivative, preparation thereof, chemical intermediates therein, pharmaceutical composition and use
ZA879235B (en) Peridone derivatives,and their preparation and use
IL81355A0 (en) 8alpha-acylaminoergolines,their production and pharmaceutical compositions containing them
ZA872739B (en) Benzimidazolesulfonamides and imidazopyridine-sulfonamides,their preparation and their application as drugs
ZA878881B (en) Medicaments based on derivatives of 3,4-diphenylpiperidine,the use of the derivatives as medicaments,and novel 3,4-diphenylpiperidine derivatives and a process for the preparation thereof
IL87134A0 (en) Preparation of 1,2,4-triazol-3-ones
EP0238357A3 (en) 1,2,4-triazinone derivatives, their preparation and use
EP0267873A3 (en) Thioquinacridones and isoquinacridones, process to manufacture them and their use
IL84366A0 (en) 2,6-diamino-3-halogenbenzylpyridines,their manufacture and pharmaceutical compositions containing them