FR2401913A1 - Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcanes et medicament les contenant - Google Patents
Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcanes et medicament les contenantInfo
- Publication number
- FR2401913A1 FR2401913A1 FR7826195A FR7826195A FR2401913A1 FR 2401913 A1 FR2401913 A1 FR 2401913A1 FR 7826195 A FR7826195 A FR 7826195A FR 7826195 A FR7826195 A FR 7826195A FR 2401913 A1 FR2401913 A1 FR 2401913A1
- Authority
- FR
- France
- Prior art keywords
- azacycloalcanes
- substitute
- hydroxy
- phenyl
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
Abstract
L'invention a trait au domaine de la chimie médicale. Elle concerne de nouveaux azacycloalcanes et leurs dérivés, y compris des analogues insaturés, chacun portant en position 3 un groupe 2-hydroxyphényle substitué en position 4 par un radical alkyle qui peut porter un atome d'oxygène, faisant partie de sa chaîne ou un groupe aralkyle qui peut porter un atome d'oxygène comme partie de sa chaîne alkylique. Les composés de l'invention agissent sur le système nerveux central; ils sont notamment doues de propriétés analgésiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/832,869 US4147872A (en) | 1977-09-13 | 1977-09-13 | 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2401913A1 true FR2401913A1 (fr) | 1979-03-30 |
FR2401913B1 FR2401913B1 (fr) | 1983-01-21 |
Family
ID=25262819
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7826195A Granted FR2401913A1 (fr) | 1977-09-13 | 1978-09-12 | Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcanes et medicament les contenant |
FR7905183A Granted FR2412531A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2-hydroxy-4-(substituant)-phenyl)-azacycloalcanones |
FR7905184A Granted FR2412530A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2'-hydroxy-4'(substituant)-phenyl)-4-alkylidene ou 4-phenylalkylidene-azacycloalcanes |
FR7905185A Granted FR2412529A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7905183A Granted FR2412531A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2-hydroxy-4-(substituant)-phenyl)-azacycloalcanones |
FR7905184A Granted FR2412530A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2'-hydroxy-4'(substituant)-phenyl)-4-alkylidene ou 4-phenylalkylidene-azacycloalcanes |
FR7905185A Granted FR2412529A1 (fr) | 1977-09-13 | 1979-02-28 | Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols |
Country Status (23)
Country | Link |
---|---|
US (1) | US4147872A (fr) |
JP (5) | JPS5935397B2 (fr) |
AR (2) | AR222019A1 (fr) |
AT (1) | AT368753B (fr) |
AU (1) | AU507953B1 (fr) |
BE (1) | BE870403A (fr) |
CA (1) | CA1113463A (fr) |
CH (1) | CH638187A5 (fr) |
DE (1) | DE2839883A1 (fr) |
DK (1) | DK401078A (fr) |
ES (2) | ES473287A1 (fr) |
FI (1) | FI66173C (fr) |
FR (4) | FR2401913A1 (fr) |
GB (1) | GB2004548B (fr) |
IE (1) | IE47717B1 (fr) |
IL (1) | IL55555A (fr) |
IT (1) | IT1099026B (fr) |
LU (1) | LU80219A1 (fr) |
NL (1) | NL7809272A (fr) |
PH (1) | PH15372A (fr) |
PT (1) | PT68542A (fr) |
SE (2) | SE7809606L (fr) |
YU (1) | YU215678A (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
FI792076A (fi) * | 1978-07-05 | 1980-01-06 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya fenylpiperidinderivat |
US4302590A (en) * | 1979-02-23 | 1981-11-24 | Hoechst-Roussel Pharmaceuticals, Inc. | Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines |
US4312876A (en) * | 1979-02-23 | 1982-01-26 | Hoechst-Roussel Pharmaceuticals Incorporated | Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines |
US4216218A (en) * | 1979-02-23 | 1980-08-05 | American Hoechst Corporation | Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines |
ZA821888B (en) * | 1981-04-01 | 1983-02-23 | Haessle Ab | Novel phenyl-piperidines |
US4709016A (en) * | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
US4529732A (en) * | 1983-03-14 | 1985-07-16 | Pfizer Inc. | 2-[2-Hydroxy-4-(substituted)phenyl]piperidines |
FI864570A0 (fi) * | 1986-11-11 | 1986-11-11 | Farmos Oy | Terapeutiskt anvaendbar foerening. |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
AU2003265659A1 (en) * | 2002-08-23 | 2004-03-11 | University Of Connecticut | Novel biphenyl and biphenyl-like cannabinoids |
DE102004036349A1 (de) * | 2004-07-27 | 2006-03-23 | Grünenthal GmbH | Substituierte 3-Phenylpiperidin-Derivate |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
WO2010095940A2 (fr) | 2009-02-20 | 2010-08-26 | To-Bbb Holding B.V. | Sustème d'administration de médicament à base de glutathionne |
NZ596876A (en) | 2009-05-06 | 2014-01-31 | Lab Skin Care Inc | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
BR112015019208A2 (pt) * | 2013-02-14 | 2017-07-18 | Galderma Res & Dev | processo de síntese |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2310761A1 (fr) * | 1975-05-16 | 1976-12-10 | Roussel Uclaf | Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments |
-
1977
- 1977-09-13 US US05/832,869 patent/US4147872A/en not_active Expired - Lifetime
-
1978
- 1978-09-12 GB GB7836419A patent/GB2004548B/en not_active Expired
- 1978-09-12 ES ES473287A patent/ES473287A1/es not_active Expired
- 1978-09-12 DK DK401078A patent/DK401078A/da not_active Application Discontinuation
- 1978-09-12 FI FI782793A patent/FI66173C/fi not_active IP Right Cessation
- 1978-09-12 IE IE1837/78A patent/IE47717B1/en unknown
- 1978-09-12 PT PT68542A patent/PT68542A/pt unknown
- 1978-09-12 JP JP53112171A patent/JPS5935397B2/ja not_active Expired
- 1978-09-12 AU AU39778/78A patent/AU507953B1/en not_active Expired
- 1978-09-12 YU YU02156/78A patent/YU215678A/xx unknown
- 1978-09-12 LU LU80219A patent/LU80219A1/fr unknown
- 1978-09-12 CA CA311,113A patent/CA1113463A/fr not_active Expired
- 1978-09-12 IT IT27557/78A patent/IT1099026B/it active
- 1978-09-12 AT AT0658078A patent/AT368753B/de not_active IP Right Cessation
- 1978-09-12 SE SE7809606A patent/SE7809606L/xx unknown
- 1978-09-12 FR FR7826195A patent/FR2401913A1/fr active Granted
- 1978-09-12 BE BE190418A patent/BE870403A/fr not_active IP Right Cessation
- 1978-09-12 NL NL7809272A patent/NL7809272A/xx not_active Application Discontinuation
- 1978-09-12 IL IL55555A patent/IL55555A/xx unknown
- 1978-09-13 PH PH21600A patent/PH15372A/en unknown
- 1978-09-13 DE DE19782839883 patent/DE2839883A1/de not_active Withdrawn
- 1978-09-13 AR AR273692A patent/AR222019A1/es active
- 1978-09-13 CH CH955778A patent/CH638187A5/fr not_active IP Right Cessation
- 1978-12-13 JP JP15404678A patent/JPS5492973A/ja active Pending
- 1978-12-13 JP JP15404778A patent/JPS5538365A/ja active Pending
- 1978-12-13 JP JP15404578A patent/JPS5495577A/ja active Granted
- 1978-12-13 JP JP15404878A patent/JPS5538366A/ja active Pending
-
1979
- 1979-02-28 FR FR7905183A patent/FR2412531A1/fr active Granted
- 1979-02-28 FR FR7905184A patent/FR2412530A1/fr active Granted
- 1979-02-28 FR FR7905185A patent/FR2412529A1/fr active Granted
- 1979-05-02 ES ES480151A patent/ES480151A1/es not_active Expired
- 1979-07-10 AR AR277236A patent/AR220567A1/es active
-
1983
- 1983-10-03 SE SE8305422A patent/SE8305422D0/xx not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |