AT368753B - Verfahren zur herstellung von neuen azacycloalkanen - Google Patents

Verfahren zur herstellung von neuen azacycloalkanen

Info

Publication number
AT368753B
AT368753B AT0658078A AT658078A AT368753B AT 368753 B AT368753 B AT 368753B AT 0658078 A AT0658078 A AT 0658078A AT 658078 A AT658078 A AT 658078A AT 368753 B AT368753 B AT 368753B
Authority
AT
Austria
Prior art keywords
azacycloalcanes
producing new
producing
new
new azacycloalcanes
Prior art date
Application number
AT0658078A
Other languages
English (en)
Other versions
ATA658078A (de
Inventor
Thomas Henry Althuis
Charles Armon Harbert
Michael Ross Johnson
Lawrence Sherman Melvin Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ATA658078A publication Critical patent/ATA658078A/de
Application granted granted Critical
Publication of AT368753B publication Critical patent/AT368753B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
AT0658078A 1977-09-13 1978-09-12 Verfahren zur herstellung von neuen azacycloalkanen AT368753B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/832,869 US4147872A (en) 1977-09-13 1977-09-13 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor

Publications (2)

Publication Number Publication Date
ATA658078A ATA658078A (de) 1982-03-15
AT368753B true AT368753B (de) 1982-11-10

Family

ID=25262819

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0658078A AT368753B (de) 1977-09-13 1978-09-12 Verfahren zur herstellung von neuen azacycloalkanen

Country Status (23)

Country Link
US (1) US4147872A (de)
JP (5) JPS5935397B2 (de)
AR (2) AR222019A1 (de)
AT (1) AT368753B (de)
AU (1) AU507953B1 (de)
BE (1) BE870403A (de)
CA (1) CA1113463A (de)
CH (1) CH638187A5 (de)
DE (1) DE2839883A1 (de)
DK (1) DK401078A (de)
ES (2) ES473287A1 (de)
FI (1) FI66173C (de)
FR (4) FR2401913A1 (de)
GB (1) GB2004548B (de)
IE (1) IE47717B1 (de)
IL (1) IL55555A (de)
IT (1) IT1099026B (de)
LU (1) LU80219A1 (de)
NL (1) NL7809272A (de)
PH (1) PH15372A (de)
PT (1) PT68542A (de)
SE (2) SE7809606L (de)
YU (1) YU215678A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FI792076A7 (fi) * 1978-07-05 1981-01-01 Ciba Geigy Ag Menetelmä uusien fenyylipiperidiinijohdannaisten valmistamiseksi.
US4312876A (en) * 1979-02-23 1982-01-26 Hoechst-Roussel Pharmaceuticals Incorporated Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
US4302590A (en) * 1979-02-23 1981-11-24 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
ZA821888B (en) * 1981-04-01 1983-02-23 Haessle Ab Novel phenyl-piperidines
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4529732A (en) * 1983-03-14 1985-07-16 Pfizer Inc. 2-[2-Hydroxy-4-(substituted)phenyl]piperidines
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
AU2003265659A1 (en) * 2002-08-23 2004-03-11 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
DE102004036349A1 (de) * 2004-07-27 2006-03-23 Grünenthal GmbH Substituierte 3-Phenylpiperidin-Derivate
EP2392258B1 (de) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-Informatiksystem
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
JP2016511761A (ja) * 2013-02-14 2016-04-21 ガルデルマ・リサーチ・アンド・デヴェロップメント ４−ピペリジン−４−イル−ベンゼン−１，３−ジオール及びその塩の合成方法、並びに新規化合物ｔｅｒｔ−ブチル４−（２，４−ジヒドロキシ−フェニル）−４−ヒドロキシ−ピペリジン−１−カルボキシレート

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310761A1 (fr) * 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
FR2401913A1 (fr) 1979-03-30
IE47717B1 (en) 1984-05-30
CA1113463A (en) 1981-12-01
ES480151A1 (es) 1980-04-01
ATA658078A (de) 1982-03-15
AR222019A1 (es) 1981-04-15
FI66173B (fi) 1984-05-31
JPS5935397B2 (ja) 1984-08-28
FR2412530B1 (de) 1982-11-12
GB2004548B (en) 1982-03-24
JPS5495577A (en) 1979-07-28
FI66173C (fi) 1984-09-10
NL7809272A (nl) 1979-03-15
JPS5538366A (en) 1980-03-17
JPS5538365A (en) 1980-03-17
FR2412530A1 (fr) 1979-07-20
SE8305422D0 (sv) 1983-10-03
FI782793A7 (fi) 1979-03-14
FR2412531B1 (de) 1983-01-14
DE2839883A1 (de) 1979-03-15
SE8305422L (sv) 1983-10-03
IL55555A (en) 1982-08-31
JPS5640155B2 (de) 1981-09-18
DK401078A (da) 1979-03-14
IT1099026B (it) 1985-09-18
IL55555A0 (en) 1978-12-17
FR2412529A1 (fr) 1979-07-20
US4147872A (en) 1979-04-03
YU215678A (en) 1983-06-30
JPS5492973A (en) 1979-07-23
JPS5463086A (en) 1979-05-21
PT68542A (en) 1978-10-01
GB2004548A (en) 1979-04-04
AU507953B1 (en) 1980-03-06
ES473287A1 (es) 1980-03-01
SE7809606L (sv) 1979-03-14
FR2401913B1 (de) 1983-01-21
AR220567A1 (es) 1980-11-14
FR2412531A1 (fr) 1979-07-20
FR2412529B1 (de) 1983-01-14
IT7827557A0 (it) 1978-09-12
BE870403A (fr) 1979-03-12
LU80219A1 (fr) 1980-04-21
IE781837L (en) 1979-03-13
CH638187A5 (fr) 1983-09-15
PH15372A (en) 1982-12-10

Similar Documents

Publication Publication Date Title
AT372093B (de) Verfahren zur herstellung von neuen corticoid-17- alkylcarbonaten
AT367425B (de) Verfahren zur herstellung von neuen cephemderivaten
AT367426B (de) Verfahren zur herstellung von neuen cephemderivaten
AT360153B (de) Verfahren zur herstellung von neuen ver- bindungen
AT362065B (de) Verfahren zur herstellung von neuen pleuromutilinglycosidderivaten
LU79212A1 (de) Verfahren zur herstellung von neuen 4-acylamino-phenylaethanolaminen
AT363182B (de) Verfahren zur herstellung von neuen cephemderivaten
AT371455B (de) Verfahren zur herstellung von neuen prostanderivaten
AT368753B (de) Verfahren zur herstellung von neuen azacycloalkanen
AT361455B (de) Verfahren zur herstellung von neuen substituierten 3-phenyl-cycloalkan- oder - -cycloalken-1-olen
AT368137B (de) Verfahren zur herstellung von neuen 4-amino-5alkylthiopyrimidinen
AT366368B (de) Verfahren zur herstellung von neuen chinolylguanidinen
AT357673B (de) Verfahren zur herstellung von neuen 9-amino- desoxyclavulansaeurederivaten
AT361622B (de) Verfahren zur herstellung von neuen anthra- cyclinglycosid-anitbiotika
AT365591B (de) Verfahren zur herstellung von neuen indolderivaten
AT358169B (de) Verfahren zur herstellung von neuen ver- bindungen
AT357677B (de) Verfahren zur herstellung von neuen azacyclyl- -verbindungen
AT362368B (de) Verfahren zur herstellung von neuen oxazolidin- 2-on-derivaten
AT372690B (de) Verfahren zur herstellung von neuen polyhydantoinen
AT360676B (de) Verfahren zur herstellung von neuen 17beta- -hydroxy-4-androsten-3-onen
AT371109B (de) Verfahren zur herstellung von neuen benzolsulfonamidderivaten
ATA750578A (de) Verfahren zur herstellung von neuen pyridothiazo- linen
AT365203B (de) Verfahren zur herstellung von neuen 9-fluorprednisolon-derivaten
AT359517B (de) Verfahren zur herstellung von neuen alfa- -halogenaethylcarbamidsaeurehalogeniden
AT372954B (de) Verfahren zur herstellung von neuen spirobenzofuranonverbindungen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee