FR2412529A1 - Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols - Google Patents

Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols

Info

Publication number
FR2412529A1
FR2412529A1 FR7905185A FR7905185A FR2412529A1 FR 2412529 A1 FR2412529 A1 FR 2412529A1 FR 7905185 A FR7905185 A FR 7905185A FR 7905185 A FR7905185 A FR 7905185A FR 2412529 A1 FR2412529 A1 FR 2412529A1
Authority
FR
France
Prior art keywords
hydroxy
substitute
phenyl
azacycloalcane
ols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7905185A
Other languages
English (en)
Other versions
FR2412529B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2412529A1 publication Critical patent/FR2412529A1/fr
Application granted granted Critical
Publication of FR2412529B1 publication Critical patent/FR2412529B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)

Abstract

L'INVENTION CONCERNE DE NOUVEAUX DERIVES DU TYPE 4-PIPERIDINOLS OU DE SES HOMOLOGUES AYANT 4 A 7 ATOMES DE CARBONE DANS LE NOYAU AZACYCLOALCANOL. CES DERIVES PORTENT EN POSITION 3 UN GROUPE 2-HYDROXY-4(SUBSTITUANT)PHENYLE, EN POSITION 4 UN GROUPE HYDROXY ET EVENTUELLEMENT D'AUTRES SUBSTITUANTS EN POSITIONS 1 ET 4. LES DERIVES EN QUESTION SONT UTILES POUR LA PREPARATION DE MEDICAMENTS.
FR7905185A 1977-09-13 1979-02-28 Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols Granted FR2412529A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/832,869 US4147872A (en) 1977-09-13 1977-09-13 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor

Publications (2)

Publication Number Publication Date
FR2412529A1 true FR2412529A1 (fr) 1979-07-20
FR2412529B1 FR2412529B1 (fr) 1983-01-14

Family

ID=25262819

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7826195A Granted FR2401913A1 (fr) 1977-09-13 1978-09-12 Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcanes et medicament les contenant
FR7905185A Granted FR2412529A1 (fr) 1977-09-13 1979-02-28 Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcane-4-ols
FR7905183A Granted FR2412531A1 (fr) 1977-09-13 1979-02-28 Nouveaux 3-(2-hydroxy-4-(substituant)-phenyl)-azacycloalcanones
FR7905184A Granted FR2412530A1 (fr) 1977-09-13 1979-02-28 Nouveaux 3-(2'-hydroxy-4'(substituant)-phenyl)-4-alkylidene ou 4-phenylalkylidene-azacycloalcanes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7826195A Granted FR2401913A1 (fr) 1977-09-13 1978-09-12 Nouveaux 3-(2-hydroxy-4(substituant)-phenyl)-azacycloalcanes et medicament les contenant

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7905183A Granted FR2412531A1 (fr) 1977-09-13 1979-02-28 Nouveaux 3-(2-hydroxy-4-(substituant)-phenyl)-azacycloalcanones
FR7905184A Granted FR2412530A1 (fr) 1977-09-13 1979-02-28 Nouveaux 3-(2'-hydroxy-4'(substituant)-phenyl)-4-alkylidene ou 4-phenylalkylidene-azacycloalcanes

Country Status (23)

Country Link
US (1) US4147872A (fr)
JP (5) JPS5935397B2 (fr)
AR (2) AR222019A1 (fr)
AT (1) AT368753B (fr)
AU (1) AU507953B1 (fr)
BE (1) BE870403A (fr)
CA (1) CA1113463A (fr)
CH (1) CH638187A5 (fr)
DE (1) DE2839883A1 (fr)
DK (1) DK401078A (fr)
ES (2) ES473287A1 (fr)
FI (1) FI66173C (fr)
FR (4) FR2401913A1 (fr)
GB (1) GB2004548B (fr)
IE (1) IE47717B1 (fr)
IL (1) IL55555A (fr)
IT (1) IT1099026B (fr)
LU (1) LU80219A1 (fr)
NL (1) NL7809272A (fr)
PH (1) PH15372A (fr)
PT (1) PT68542A (fr)
SE (2) SE7809606L (fr)
YU (1) YU215678A (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FI792076A (fi) * 1978-07-05 1980-01-06 Ciba Geigy Ag Foerfarande foer framstaellning av nya fenylpiperidinderivat
US4302590A (en) * 1979-02-23 1981-11-24 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
US4312876A (en) * 1979-02-23 1982-01-26 Hoechst-Roussel Pharmaceuticals Incorporated Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
ZA821888B (en) * 1981-04-01 1983-02-23 Haessle Ab Novel phenyl-piperidines
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4529732A (en) * 1983-03-14 1985-07-16 Pfizer Inc. 2-[2-Hydroxy-4-(substituted)phenyl]piperidines
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN1671639A (zh) * 2002-08-23 2005-09-21 康涅狄格大学 新型联苯大麻素和类似联苯的大麻素
DE102004036349A1 (de) * 2004-07-27 2006-03-23 Grünenthal GmbH Substituierte 3-Phenylpiperidin-Derivate
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (fr) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
US8445002B2 (en) 2009-05-06 2013-05-21 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA2900309A1 (fr) * 2013-02-14 2014-08-21 Galderma Research & Development Procede de synthese de 4-piperidin-4-yl-benzene-1,3-diol et de ses sels et nouveau compose 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310761A1 (fr) * 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
SE8305422L (sv) 1983-10-03
GB2004548B (en) 1982-03-24
IT7827557A0 (it) 1978-09-12
JPS5538365A (en) 1980-03-17
JPS5935397B2 (ja) 1984-08-28
DE2839883A1 (de) 1979-03-15
JPS5492973A (en) 1979-07-23
PT68542A (en) 1978-10-01
FR2412531B1 (fr) 1983-01-14
JPS5538366A (en) 1980-03-17
IT1099026B (it) 1985-09-18
BE870403A (fr) 1979-03-12
FR2412529B1 (fr) 1983-01-14
FI66173B (fi) 1984-05-31
IL55555A (en) 1982-08-31
SE7809606L (sv) 1979-03-14
CH638187A5 (fr) 1983-09-15
JPS5640155B2 (fr) 1981-09-18
NL7809272A (nl) 1979-03-15
FR2412530B1 (fr) 1982-11-12
US4147872A (en) 1979-04-03
AU507953B1 (en) 1980-03-06
IE781837L (en) 1979-03-13
PH15372A (en) 1982-12-10
FR2412530A1 (fr) 1979-07-20
JPS5495577A (en) 1979-07-28
DK401078A (da) 1979-03-14
AR222019A1 (es) 1981-04-15
LU80219A1 (fr) 1980-04-21
ES480151A1 (es) 1980-04-01
ES473287A1 (es) 1980-03-01
AR220567A1 (es) 1980-11-14
AT368753B (de) 1982-11-10
FI782793A (fi) 1979-03-14
SE8305422D0 (sv) 1983-10-03
YU215678A (en) 1983-06-30
IE47717B1 (en) 1984-05-30
FR2401913B1 (fr) 1983-01-21
GB2004548A (en) 1979-04-04
ATA658078A (de) 1982-03-15
CA1113463A (fr) 1981-12-01
IL55555A0 (en) 1978-12-17
FI66173C (fi) 1984-09-10
JPS5463086A (en) 1979-05-21
FR2412531A1 (fr) 1979-07-20
FR2401913A1 (fr) 1979-03-30

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