ES2002425A6 - Un procedimiento para preparar nuevos derivados de flavona - Google Patents

Un procedimiento para preparar nuevos derivados de flavona

Info

Publication number
ES2002425A6
ES2002425A6 ES8602677A ES8602677A ES2002425A6 ES 2002425 A6 ES2002425 A6 ES 2002425A6 ES 8602677 A ES8602677 A ES 8602677A ES 8602677 A ES8602677 A ES 8602677A ES 2002425 A6 ES2002425 A6 ES 2002425A6
Authority
ES
Spain
Prior art keywords
formula
compounds
activity
derivatives
flavone derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8602677A
Other languages
English (en)
Inventor
Amedeo Leonardi
Renzo Pennini
Pietro Cazzulani
Dante Nardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Recordati SA
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA filed Critical Recordati SA
Publication of ES2002425A6 publication Critical patent/ES2002425A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE FLAVONA. LOS COMPUESTOS DE FORMULA (I) EN LOS QUE R, R1, R2 Y R3 REPRESENTAN VARIOS RADICALES ORGANICOS, SE OBTIENEN POR REACCION DE UN ALDEHIDO DE FORMULA (II) CON UN CETO-ESTER DE FORMULA (III) Y CON UNA ENAMINA DE FORMULA (IV). ESTOS COMPUESTOS DE FORMULA (I) SON UTILES POR SU ACTIVIDAD ANTAGONICA DEL CALCIO ASI COMO POR SU ACTIVIDAD RELAJANTE DE LA MUSCULATURA LISA, EN PARTICULAR DE LA VEJIGA.
ES8602677A 1985-10-22 1986-10-20 Un procedimiento para preparar nuevos derivados de flavona Expired ES2002425A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22578/85A IT1190405B (it) 1985-10-22 1985-10-22 Derivati del flavone

Publications (1)

Publication Number Publication Date
ES2002425A6 true ES2002425A6 (es) 1988-08-01

Family

ID=11198039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8602677A Expired ES2002425A6 (es) 1985-10-22 1986-10-20 Un procedimiento para preparar nuevos derivados de flavona

Country Status (26)

Country Link
US (1) US4806534A (es)
EP (1) EP0223744B1 (es)
JP (1) JPH0772186B2 (es)
KR (1) KR910009269B1 (es)
CN (1) CN86107544A (es)
AR (1) AR243883A1 (es)
AT (1) ATE73453T1 (es)
AU (1) AU596382B2 (es)
CA (1) CA1330994C (es)
DE (1) DE3684244D1 (es)
DK (1) DK169408B1 (es)
EG (1) EG18109A (es)
ES (1) ES2002425A6 (es)
FI (1) FI89167C (es)
GR (1) GR862546B (es)
HU (1) HU202863B (es)
IE (1) IE58330B1 (es)
IL (1) IL80229A0 (es)
IT (1) IT1190405B (es)
NO (1) NO167570C (es)
NZ (1) NZ217964A (es)
PH (1) PH22766A (es)
PT (1) PT83604B (es)
SG (1) SG55192G (es)
TN (1) TNSN86144A1 (es)
ZA (1) ZA867941B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912223A (en) * 1988-01-28 1990-03-27 Nelson Research & Development Co. 1,4-Dihydropyridines
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
US5244602A (en) * 1990-12-03 1993-09-14 Ppg Industries, Inc. Photochromic naphthopyrans
DE4321030A1 (de) * 1993-06-24 1995-01-05 Bayer Ag 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel
SE9703377D0 (sv) * 1997-09-18 1997-09-18 Astra Ab New compounds
KR100392468B1 (ko) * 2000-09-18 2003-07-22 주식회사 엘지생명과학 사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체
MXPA03006250A (es) 2001-01-16 2003-09-22 Astrazeneca Ab Compuestos heterociclicos terapeuticos.
DE102005034267A1 (de) * 2005-07-22 2007-01-25 Bayer Healthcare Ag 4-Chromenonyl-1,4-dihydropyridine und ihre Verwendung
DE102005034264A1 (de) * 2005-07-22 2007-02-01 Bayer Healthcare Ag 4-Chromenonyl-1,4-dihydropyridincarbonitrile und ihre Verwendung
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
JP7308369B2 (ja) 2021-05-03 2023-07-13 ペトラ・ファーマ・コーポレイション 疾患の治療のためのホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤
EP4347040A1 (en) 2021-05-27 2024-04-10 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921070A (en) * 1957-11-05 1960-01-12 Recordati Lab Farmacologico S Basic esters of 3-methylflavone-8-carboxylic acid
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3311005A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
NZ217964A (en) 1990-04-26
PT83604A (en) 1986-11-01
KR910009269B1 (ko) 1991-11-08
FI864260A0 (fi) 1986-10-21
FI89167B (fi) 1993-05-14
ATE73453T1 (de) 1992-03-15
NO864108D0 (no) 1986-10-15
CN86107544A (zh) 1987-11-25
NO167570C (no) 1991-11-20
DK506386A (da) 1987-04-23
HU202863B (en) 1991-04-29
DE3684244D1 (de) 1992-04-16
ZA867941B (en) 1987-06-24
EP0223744A3 (en) 1988-09-14
EG18109A (en) 1992-08-30
FI864260A (fi) 1987-04-23
CA1330994C (en) 1994-07-26
AU6427386A (en) 1987-04-30
EP0223744B1 (en) 1992-03-11
FI89167C (fi) 1993-08-25
HUT45525A (en) 1988-07-28
IT8522578A0 (it) 1985-10-22
DK506386D0 (da) 1986-10-22
IE58330B1 (en) 1993-09-08
EP0223744A2 (en) 1987-05-27
KR870004022A (ko) 1987-05-07
IT1190405B (it) 1988-02-16
PT83604B (pt) 1988-10-14
NO864108L (no) 1987-04-23
JPS62161781A (ja) 1987-07-17
US4806534A (en) 1989-02-21
PH22766A (en) 1988-12-12
TNSN86144A1 (fr) 1990-01-01
GR862546B (en) 1987-03-04
IL80229A0 (en) 1987-01-30
AR243883A1 (es) 1993-09-30
AU596382B2 (en) 1990-05-03
SG55192G (en) 1992-07-24
NO167570B (no) 1991-08-12
DK169408B1 (da) 1994-10-24
IE862768L (en) 1987-04-22
JPH0772186B2 (ja) 1995-08-02

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-10-20