ES2064530T3 - Compuestos de triazina o triazolo heterociclicos con actividad de antagonista de 2-receptor de serotonina. - Google Patents

Compuestos de triazina o triazolo heterociclicos con actividad de antagonista de 2-receptor de serotonina.

Info

Publication number
ES2064530T3
ES2064530T3 ES90110479T ES90110479T ES2064530T3 ES 2064530 T3 ES2064530 T3 ES 2064530T3 ES 90110479 T ES90110479 T ES 90110479T ES 90110479 T ES90110479 T ES 90110479T ES 2064530 T3 ES2064530 T3 ES 2064530T3
Authority
ES
Spain
Prior art keywords
antagonist activity
serotonin
triazine
hetero
cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90110479T
Other languages
English (en)
Inventor
Yoshifumi C O Researc Watanabe
Hiroyuki C O Research Ins Usui
Toshiro C O Research I Shibano
Tsuyoshi C O Research I Tanaka
Yoshiyuki C O Resear Morishima
Megumi C O Research In Yasuoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1310346A external-priority patent/JPH03170431A/ja
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2064530T3 publication Critical patent/ES2064530T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE PRESENTAN LOS COMPUESTOS REPRESENTADOS POR LA FORMULA (I), SUS SALES Y SUS INTERMEDIARIOS. DICHOS COMPUESTOS, JUNTO CON SUS SALES MUESTRAN UNA ACTIVIDAD ANTAGONISTA SELECTIVA AL 2-RECEPTOR DE LA SEROTONINA, Y SON UTILES PARA LA PREVENCION, ASI COMO, PARA EL TRATAMIENTO DE ENFERMEDADES CIRCULARORIAS, POR EJEMPLO, ENFERMEDADES CARDIACAS ISQUIMICAS, PERTURBACIONES CEREBRALES Y TRASTORNOS EN LA CIRCULACION PERIFERICA.
ES90110479T 1989-06-05 1990-06-01 Compuestos de triazina o triazolo heterociclicos con actividad de antagonista de 2-receptor de serotonina. Expired - Lifetime ES2064530T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14239789 1989-06-05
JP18861789 1989-07-20
JP20203989 1989-08-03
JP1310346A JPH03170431A (ja) 1989-11-29 1989-11-29 心臓疾患治療剤

Publications (1)

Publication Number Publication Date
ES2064530T3 true ES2064530T3 (es) 1995-02-01

Family

ID=27472451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90110479T Expired - Lifetime ES2064530T3 (es) 1989-06-05 1990-06-01 Compuestos de triazina o triazolo heterociclicos con actividad de antagonista de 2-receptor de serotonina.

Country Status (17)

Country Link
US (1) US5232924A (es)
EP (1) EP0401707B1 (es)
KR (1) KR910000755A (es)
CN (1) CN1049161A (es)
AT (1) ATE111911T1 (es)
AU (1) AU628579B2 (es)
CA (1) CA2018220A1 (es)
DE (1) DE69012653T2 (es)
DK (1) DK0401707T3 (es)
ES (1) ES2064530T3 (es)
FI (1) FI902763A7 (es)
HU (1) HUT54365A (es)
IL (1) IL94592A (es)
NO (1) NO174712C (es)
NZ (1) NZ233917A (es)
PT (1) PT94270A (es)
YU (1) YU108790A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
CA2108245A1 (en) * 1992-11-04 1994-05-05 Gary J. Grover Method for treating myocardial ischemia employing serotonin receptor antagonists
TW200608978A (en) * 2004-05-28 2006-03-16 Speedel Experimenta Ag Organic compounds
RU2376307C1 (ru) * 2008-05-27 2009-12-20 Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук 4-((Z)-4'-ГИДРОКСИБУТЕН-2'-ИЛ)-2-R-6-ФЕНИЛ-1,2,4-ТРИАЗОЛО[5,1-c][1,2,4]ТРИАЗИН-7-ОНЫ
PT2399910E (pt) 2009-02-13 2014-05-02 Shionogi & Co Novo derivado de triazina e composição farmacéutica que contém o mesmo
US9212130B2 (en) 2010-08-10 2015-12-15 Shionogi & Co., Ltd. Heterocyclic derivative and pharmaceutical composition comprising the same
PL2604595T3 (pl) 2010-08-10 2016-09-30 Pochodna triazyny i związek farmaceutyczny, który ją zawiera i wykazuje aktywność przeciwbólową
US9266881B2 (en) * 2011-11-14 2016-02-23 Merck Sharp & Dohme Corp. Triazolopyridinone PDE10 inhibitors
WO2013118855A1 (ja) 2012-02-09 2013-08-15 塩野義製薬株式会社 複素環および炭素環誘導体
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
CN113185521A (zh) * 2021-05-08 2021-07-30 新乡市润宇新材料科技有限公司 一种环丙基开环制备四氢吡咯并[1,2-a]1,3,5-三嗪-4-酮类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH499531A (de) * 1968-05-06 1970-11-30 Agripat Sa Verfahren zur Herstellung neuer Pyrido (1,2-a)-s-triazin-dione
GB1328205A (en) * 1970-10-13 1973-08-30 Lilly Industries Ltd Oxazolo-triazines
US4340597A (en) * 1981-04-13 1982-07-20 Schering Corporation 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines
DE3173762D1 (de) * 1981-06-15 1986-03-27 Nippon Soda Co Thiazolinotriazine derivatives
DE3126837A1 (de) * 1981-07-08 1983-01-27 Hoechst Ag, 6000 Frankfurt Triazino-(2,1-a)isochinolinderivate

Also Published As

Publication number Publication date
NO174712C (no) 1994-06-22
HUT54365A (en) 1991-02-28
AU628579B2 (en) 1992-09-17
DE69012653T2 (de) 1995-02-09
FI902763A7 (fi) 1990-12-06
KR910000755A (ko) 1991-01-30
CN1049161A (zh) 1991-02-13
NO902439D0 (no) 1990-06-01
HU903489D0 (en) 1990-10-28
IL94592A (en) 1994-07-31
ATE111911T1 (de) 1994-10-15
AU5629590A (en) 1990-12-06
DE69012653D1 (de) 1994-10-27
FI902763A0 (fi) 1990-06-04
DK0401707T3 (da) 1994-10-17
NO902439L (no) 1990-12-06
YU108790A (en) 1991-10-31
NO174712B (no) 1994-03-14
EP0401707B1 (en) 1994-09-21
NZ233917A (en) 1991-04-26
CA2018220A1 (en) 1990-12-05
IL94592A0 (en) 1991-04-15
PT94270A (pt) 1991-02-08
US5232924A (en) 1993-08-03
EP0401707A1 (en) 1990-12-12

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