ES8603406A1 - Un procedimiento para producir derivados de acilindol - Google Patents
Un procedimiento para producir derivados de acilindolInfo
- Publication number
- ES8603406A1 ES8603406A1 ES536293A ES536293A ES8603406A1 ES 8603406 A1 ES8603406 A1 ES 8603406A1 ES 536293 A ES536293 A ES 536293A ES 536293 A ES536293 A ES 536293A ES 8603406 A1 ES8603406 A1 ES 8603406A1
- Authority
- ES
- Spain
- Prior art keywords
- platelet
- formula
- carbon atoms
- alkyl group
- aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DE DERIVADOS DE ACILINDOL, DE FORMULA GENERAL (I), EN LA QUE R1 Y R2, QUE PUEDEN SER IGUALES O DIFERENTES, SIGNIFICAN UN ATOMO DE HIDROGENO, UN GRYPO ALQUILO INFERIOR CON 1 A 5 ATOMOS DE CARBONO O UN GRUPO ALQUILO INFERIOR, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE HACE REACCIONAR UN INDOL CON UN REACTIVO DE GRIGNARD Y A CONTINUACION CON CLORURO DE ACIDO (R2COCL); SEGUNDA, EL COMPUESTO OBTENIDO SE HACE REACCIONAR CON UN ALCANO HALOGENADO O CON UN HIDROXIALCANO HALOGENADO; Y POR ULTIMO, LA REACCION AMTERIOR SE PUEDE REALIZAR EN PRESENCIA DE UN CATALIZADOR ACIDO O BASICO. DE APLICACION EN LA PREPARACION DE FARMACOS UTILES PARA EVITAR O REMEDIAR LA TROMBOSIS, LA EMBOLIA O LAS ENFERMEDADES ORIGINADAS POR ELLAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58181084A JPH0751560B2 (ja) | 1983-09-28 | 1983-09-28 | 新規アシルインドール誘導体及び該化合物を含有する医薬組成物 |
JP59168928A JPH0647574B2 (ja) | 1984-08-11 | 1984-08-11 | 新規アシルインド−ル誘導体及び該化合物を有効成分として含有する血小板凝集抑制剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES536293A0 ES536293A0 (es) | 1985-12-16 |
ES8603406A1 true ES8603406A1 (es) | 1985-12-16 |
Family
ID=26492437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES536293A Expired ES8603406A1 (es) | 1983-09-28 | 1984-09-27 | Un procedimiento para producir derivados de acilindol |
Country Status (7)
Country | Link |
---|---|
US (1) | US4708961A (es) |
EP (1) | EP0149419B1 (es) |
AU (1) | AU574383B2 (es) |
CA (1) | CA1331604C (es) |
DE (1) | DE3473444D1 (es) |
DK (1) | DK425384A (es) |
ES (1) | ES8603406A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4803266A (en) * | 1986-10-17 | 1989-02-07 | Taisho Pharmaceutical Co., Ltd. | 3-Oxoalkylidene-2-azetidinone derivatives |
EP0264232A1 (en) * | 1986-10-17 | 1988-04-20 | Taisho Pharmaceutical Co. Ltd | 2-Azetidinone derivatives |
CA2118697A1 (en) * | 1991-09-11 | 1993-03-18 | Satoshi Okada | Indole derivatives as 5-alpha-reductase inhibitor |
AU6476700A (en) * | 1999-08-26 | 2001-03-26 | Fujisawa Pharmaceutical Co., Ltd. | Process for the preparation of indole derivatives or salts thereof |
DE19947863A1 (de) * | 1999-09-23 | 2001-04-05 | Werner Loewe | Salicyloyl-substituierte Indolderivate und ihre Verwendung |
GB9923314D0 (en) * | 1999-10-01 | 1999-12-08 | Pfizer Ltd | Acylation process |
US20050256117A1 (en) * | 2002-06-14 | 2005-11-17 | Meng Hsin Chen | Ophthalmic compositions for treating ocular hypertension |
CN104945376B (zh) * | 2015-07-09 | 2017-03-15 | 安徽理工大学 | 一种3‑芳酰基吲哚化合物的合成方法 |
WO2019141259A1 (zh) * | 2018-01-19 | 2019-07-25 | 苏州信诺维医药科技有限公司 | 杂环化合物、制备方法及其在医药上的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB869775A (en) * | 1958-09-24 | 1961-06-07 | Upjohn Co | 3-indolyl ketones |
DE3062613D1 (en) * | 1979-06-28 | 1983-05-11 | Teijin Ltd | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them |
JPS609761A (ja) * | 1983-06-30 | 1985-01-18 | Toshiba Corp | カラ−シリアルプリンタ |
-
1984
- 1984-09-06 DK DK425384A patent/DK425384A/da not_active Application Discontinuation
- 1984-09-06 AU AU32762/84A patent/AU574383B2/en not_active Ceased
- 1984-09-17 CA CA000463386A patent/CA1331604C/en not_active Expired - Fee Related
- 1984-09-24 DE DE8484810466T patent/DE3473444D1/de not_active Expired
- 1984-09-24 EP EP84810466A patent/EP0149419B1/en not_active Expired
- 1984-09-27 ES ES536293A patent/ES8603406A1/es not_active Expired
-
1986
- 1986-10-16 US US06/919,746 patent/US4708961A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK425384A (da) | 1985-03-29 |
CA1331604C (en) | 1994-08-23 |
ES536293A0 (es) | 1985-12-16 |
AU574383B2 (en) | 1988-07-07 |
EP0149419A1 (en) | 1985-07-24 |
DK425384D0 (da) | 1984-09-06 |
AU3276284A (en) | 1985-04-04 |
DE3473444D1 (en) | 1988-09-22 |
US4708961A (en) | 1987-11-24 |
EP0149419B1 (en) | 1988-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8605806A1 (es) | Procedimiento de preparacion de nuevos derivados de la xan- tina y de sus sales de adicion con acidos apropiados | |
MX9804457A (es) | Inhibidores de las metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y metodos y compuestos intermedios utiles para su preparacion. | |
DE3271269D1 (en) | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
ES8306160A1 (es) | "procedimiento para preparar un nuevo compuesto de cefem". | |
ES2076009T3 (es) | Nuevos inhibidores de n-miristoil-transferasa, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
ES488656A1 (es) | Procedimiento para la preparacion de derivados de acidos aziridin-2-carboxilicos substituidos en n | |
ES8603406A1 (es) | Un procedimiento para producir derivados de acilindol | |
GR3001506T3 (en) | N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | |
DE3574256D1 (en) | New cephem compounds, process for preparation thereof and pharmaceutical compositions containing them | |
ES8404360A1 (es) | Un procedimiento para preparar compuestos de cefem. | |
ES2056073T3 (es) | Aril-aralquil-eteres, procedimientos para su preparacion y composicion farmaceutica que los comprende. | |
AU558261B2 (en) | Dialkylaminoalkyoxybenzylalcohol derivatives | |
GB9100028D0 (en) | Compounds | |
NZ227082A (en) | N-(23-vinblastinoyl) derivatives of 1-aminomethyl-phosphonic acid; process for their preparation; and pharmaceutical compositions containing them | |
HUT58269A (en) | Process for producing aralkyl-amine derivatives and pharmaceutical compositions containing them as active components | |
SE8205868L (sv) | Vissa 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel och kompositioner innehallande dem | |
IN162570B (es) | ||
ES8304133A1 (es) | "procedimiento para preparar nuevos derivados de triazoloquinazolinona". | |
KR880013896A (ko) | 벤조푸로[3,2-c]퀴놀린 화합물 | |
ATE29251T1 (de) | Aminopyridincarbonsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
SE8205767L (sv) | Vissa mono-substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt kompositioner innehallande dem |