FR2372176A1 - Procede de preparation de derives d'alcoxy-3 androstanones-17 - Google Patents

Procede de preparation de derives d'alcoxy-3 androstanones-17

Info

Publication number
FR2372176A1
FR2372176A1 FR7806457A FR7806457A FR2372176A1 FR 2372176 A1 FR2372176 A1 FR 2372176A1 FR 7806457 A FR7806457 A FR 7806457A FR 7806457 A FR7806457 A FR 7806457A FR 2372176 A1 FR2372176 A1 FR 2372176A1
Authority
FR
France
Prior art keywords
derivatives
preparation
androstanones
alcoxy
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7806457A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of FR2372176A1 publication Critical patent/FR2372176A1/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Abstract

Procédé de préparation de dérivés de l'androstane répondant à la formule génerale VI dans laquelle n désigne le nombre 1 ou 2, R1 represente un atome d'hydrogène ou un radical alkyle inférieur, R2 représente un radical alkyle éventuellement interrompu par un atome d'oxygène ou encore, lorsque n est égal à 2, peut représenter un atome d'hydrogène, et X représente un groupe carbonyle ou hydroxyméthylène, procédé caractérisé en ce qu'on hydrogène un dérivé de l'androstène-5 one-17 de formule générale Ic dans laquelle n, R 1 et R2 sont tels que définis ci-dessus.
FR7806457A 1976-07-16 1978-03-07 Procede de preparation de derives d'alcoxy-3 androstanones-17 Pending FR2372176A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762632677 DE2632677A1 (de) 1976-07-16 1976-07-16 Verfahren zur herstellung von androstan-17-on-derivaten und deren verwendung

Publications (1)

Publication Number Publication Date
FR2372176A1 true FR2372176A1 (fr) 1978-06-23

Family

ID=5983514

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7721932A Granted FR2365588A1 (fr) 1976-07-16 1977-07-18 Procede de preparation d'androstanones-17
FR7806457A Pending FR2372176A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de derives d'alcoxy-3 androstanones-17
FR7806455A Pending FR2372175A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de l'hydroxy-3 androstanone-17 et de l'hydroxy-3 androstene-5 one-17
FR7806456A Pending FR2372174A1 (fr) 1976-07-16 1978-03-07 Procede de preparation d'alcoxy-3 hydroxy-17 androstanes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7721932A Granted FR2365588A1 (fr) 1976-07-16 1977-07-18 Procede de preparation d'androstanones-17

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7806455A Pending FR2372175A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de l'hydroxy-3 androstanone-17 et de l'hydroxy-3 androstene-5 one-17
FR7806456A Pending FR2372174A1 (fr) 1976-07-16 1978-03-07 Procede de preparation d'alcoxy-3 hydroxy-17 androstanes

Country Status (18)

Country Link
US (1) US4179336A (fr)
JP (1) JPS5315493A (fr)
AT (1) AT363196B (fr)
BE (1) BE856860A (fr)
CH (3) CH627190A5 (fr)
CS (1) CS200517B2 (fr)
DD (4) DD136142A5 (fr)
DE (1) DE2632677A1 (fr)
DK (1) DK142372C (fr)
FR (4) FR2365588A1 (fr)
GB (1) GB1585786A (fr)
HU (4) HU182790B (fr)
IE (1) IE45304B1 (fr)
IT (1) IT1077339B (fr)
NL (1) NL7706638A (fr)
SE (1) SE440779B (fr)
SU (1) SU980628A3 (fr)
YU (1) YU164277A (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55148083A (en) * 1979-05-04 1980-11-18 Mitsubishi Chem Ind Ltd Microorganism
JPS55150893A (en) * 1979-05-11 1980-11-25 Mitsubishi Chem Ind Ltd Novel microorganism
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4444884A (en) * 1982-05-25 1984-04-24 Wisconsin Alumni Research Foundation Process for preparing steroids
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids
JPH0512528Y2 (fr) * 1987-09-08 1993-03-31
DE69621281T2 (de) * 1995-02-28 2002-12-05 Nippon Catalytic Chem Ind Acryl-Säure-Derivate, Verfahren zur Herstellung von Acryl-Säure-Derivaten und Acryl-Säure-Polymere
TR201907313T4 (tr) * 2003-05-23 2019-06-21 Nektar Therapeutics İki PEG zinciri içeren PEG türevleri.
CN102656153B (zh) * 2009-10-29 2015-02-18 延世大学校产学协力团 新型血管渗漏阻断剂
US9388210B2 (en) 2011-02-25 2016-07-12 Washington University Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
US20150291654A1 (en) 2011-10-14 2015-10-15 Sage Therapeutics, Inc. 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
SI2935307T1 (en) 2012-12-18 2018-08-31 Washington University Non-reactive 19-alkoxy-17-substituted steroids useful in therapeutic procedures
EP2956466A4 (fr) * 2013-02-15 2016-11-02 Univ Washington Stéroïdes énantiomères neuroactifs susbtitués en position 15, 16 et 17, utilisés comme modulateurs de récepteurs gaba de type a
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
EP3909966A1 (fr) 2013-04-17 2021-11-17 Sage Therapeutics, Inc. Stéroïde 19-nor c3,3-disubstitué c21-n-pyrazolyl pour le traitement thérapeutique
WO2014169831A1 (fr) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor-hétéroaryl-stéroïdes c21-c-liés c3,3-disubstitués et procédés d'utilisation de ceux-ci
EP2986624B1 (fr) 2013-04-17 2020-03-25 Sage Therapeutics, Inc. Stéroïdes neuroactifs 19-nor et pour l'utilisation thérapeutique
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
RS61733B1 (sr) 2013-07-19 2021-05-31 Sage Therapeutics Inc Neuroaktivni steroidi, njihove kompozicije i upotrebe
PT3488852T (pt) 2013-08-23 2021-02-03 Sage Therapeutics Inc Esteroides neuroativos, composições e seus usos
WO2015195962A1 (fr) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations
NZ731034A (en) 2014-10-16 2024-02-23 Sage Therapeutics Inc Compositions and methods for treating cns disorders
NZ731095A (en) 2014-10-16 2023-12-22 Sage Therapeutics Inc Compositions and methods for treating cns disorders
HUE049014T2 (hu) 2014-11-27 2020-09-28 Sage Therapeutics Inc Készítmények és módszerek a központi idegrendszer rendellenességeinek kezelésére
JP6745274B2 (ja) 2015-01-26 2020-08-26 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害を処置するための組成物および方法
US10329320B2 (en) 2015-02-20 2019-06-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
EP3481845B1 (fr) 2016-07-11 2023-09-13 Sage Therapeutics, Inc. Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
JOP20210293A1 (ar) 2019-05-31 2023-01-30 Sage Therapeutics Inc ستيرويدات ذات فعالية عصبية وتركيبات منها

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451892A (en) * 1965-10-19 1969-06-24 Schering Corp Process for the preparation of steroidal compounds
NL6705450A (fr) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US3738983A (en) * 1971-08-06 1973-06-12 Searle & Co Process for the preparation of 3-(3beta,17beta-dihydroxyandrost-5-en-17alpha-yl) propionic acid gamma-lactone
DE2534911C2 (de) * 1975-08-01 1985-04-18 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 5-Androsten-17-on-Derivaten

Also Published As

Publication number Publication date
SU980628A3 (ru) 1982-12-07
FR2372174A1 (fr) 1978-06-23
US4179336A (en) 1979-12-18
BE856860A (fr) 1978-01-16
DD136142A5 (de) 1979-06-20
DE2632677A1 (de) 1978-01-26
JPS5315493A (en) 1978-02-13
DD132439A5 (de) 1978-09-27
HU182681B (en) 1984-02-28
HU179344B (en) 1982-10-28
GB1585786A (en) 1981-03-11
AT363196B (de) 1981-07-10
DD137235A5 (de) 1979-08-22
IT1077339B (it) 1985-05-04
CS200517B2 (en) 1980-09-15
DK142372C (da) 1981-03-23
SE440779B (sv) 1985-08-19
ATA504677A (de) 1980-12-15
DD136141A5 (de) 1979-06-20
YU164277A (en) 1982-08-31
IE45304L (en) 1978-01-16
CH629222A5 (de) 1982-04-15
IE45304B1 (en) 1982-07-28
JPS6117477B2 (fr) 1986-05-07
FR2365588B1 (fr) 1982-06-25
CH627190A5 (fr) 1981-12-31
HU182789B (en) 1984-03-28
NL7706638A (nl) 1978-01-18
HU182790B (en) 1984-03-28
FR2365588A1 (fr) 1978-04-21
DK142372B (da) 1980-10-20
CH629503A5 (de) 1982-04-30
DE2632677C2 (fr) 1988-06-16
DK323677A (da) 1978-01-17
SE7708192L (sv) 1978-01-17
FR2372175A1 (fr) 1978-06-23

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