HU179344B - Process for producing andorstan-17-one derivatives - Google Patents

Process for producing andorstan-17-one derivatives

Info

Publication number
HU179344B
HU179344B HU77SCHE614A HUSC000614A HU179344B HU 179344 B HU179344 B HU 179344B HU 77SCHE614 A HU77SCHE614 A HU 77SCHE614A HU SC000614 A HUSC000614 A HU SC000614A HU 179344 B HU179344 B HU 179344B
Authority
HU
Hungary
Prior art keywords
andorstan
derivatives
producing
producing andorstan
Prior art date
Application number
HU77SCHE614A
Other languages
English (en)
Inventor
Alfred Weber
Mario Kennecke
Helmut Dahl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of HU179344B publication Critical patent/HU179344B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU77SCHE614A 1976-07-16 1977-07-15 Process for producing andorstan-17-one derivatives HU179344B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762632677 DE2632677A1 (de) 1976-07-16 1976-07-16 Verfahren zur herstellung von androstan-17-on-derivaten und deren verwendung

Publications (1)

Publication Number Publication Date
HU179344B true HU179344B (en) 1982-10-28

Family

ID=5983514

Family Applications (4)

Application Number Title Priority Date Filing Date
HU8018A HU182789B (en) 1976-07-16 1977-07-15 Process for producing 3-beta-hydroxy-5-androsten-17-one
HU77SCHE614A HU179344B (en) 1976-07-16 1977-07-15 Process for producing andorstan-17-one derivatives
HU8020A HU182681B (en) 1976-07-16 1977-07-15 Process for preparing androstane derivatives
HU8019A HU182790B (en) 1976-07-16 1977-07-15 Process for preparing 17beta-hydroxy-5-androstene derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU8018A HU182789B (en) 1976-07-16 1977-07-15 Process for producing 3-beta-hydroxy-5-androsten-17-one

Family Applications After (2)

Application Number Title Priority Date Filing Date
HU8020A HU182681B (en) 1976-07-16 1977-07-15 Process for preparing androstane derivatives
HU8019A HU182790B (en) 1976-07-16 1977-07-15 Process for preparing 17beta-hydroxy-5-androstene derivatives

Country Status (18)

Country Link
US (1) US4179336A (hu)
JP (1) JPS5315493A (hu)
AT (1) AT363196B (hu)
BE (1) BE856860A (hu)
CH (3) CH627190A5 (hu)
CS (1) CS200517B2 (hu)
DD (4) DD136141A5 (hu)
DE (1) DE2632677A1 (hu)
DK (1) DK142372C (hu)
FR (4) FR2365588A1 (hu)
GB (1) GB1585786A (hu)
HU (4) HU182789B (hu)
IE (1) IE45304B1 (hu)
IT (1) IT1077339B (hu)
NL (1) NL7706638A (hu)
SE (1) SE440779B (hu)
SU (1) SU980628A3 (hu)
YU (1) YU164277A (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55148083A (en) * 1979-05-04 1980-11-18 Mitsubishi Chem Ind Ltd Microorganism
JPS55150893A (en) * 1979-05-11 1980-11-25 Mitsubishi Chem Ind Ltd Novel microorganism
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4444884A (en) * 1982-05-25 1984-04-24 Wisconsin Alumni Research Foundation Process for preparing steroids
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids
JPH0512528Y2 (hu) * 1987-09-08 1993-03-31
DE69621281T2 (de) * 1995-02-28 2002-12-05 Nippon Catalytic Chem Ind Acryl-Säure-Derivate, Verfahren zur Herstellung von Acryl-Säure-Derivaten und Acryl-Säure-Polymere
JP5048332B2 (ja) * 2003-05-23 2012-10-17 ネクター セラピューティクス 特定の原子配置を有するポリマー誘導体
WO2011053048A2 (ko) * 2009-10-29 2011-05-05 연세대학교 산학협력단 신규 혈관누출 차단제
WO2012116290A2 (en) 2011-02-25 2012-08-30 Washington University Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
CA3152410A1 (en) 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
MX365644B (es) 2012-12-18 2019-06-10 Univ Washington Esteroides neuroactivos sustituidos con 19-alcoxi-17, profarmacos de los mismos, y metodos de tratamiento usando los mismos.
US10202413B2 (en) 2013-02-15 2019-02-12 Washington University Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for GABA type-A receptors
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
CN113527400A (zh) 2013-04-17 2021-10-22 萨奇治疗股份有限公司 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
CN112110976B (zh) 2013-04-17 2023-08-29 萨奇治疗股份有限公司 刺激神经活性的19-去甲类固醇及其使用方法
LT3021852T (lt) 2013-07-19 2021-04-12 Sage Therapeutics, Inc. Neuroaktyvūs steroidai, jų kompozicijos ir panaudojimas
DK3488852T3 (da) 2013-08-23 2021-02-01 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser deraf
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
TW202235090A (zh) 2014-10-16 2022-09-16 美商賽吉醫療公司 用於治療中樞神經系統(cns)病症之組合物及方法
ES2808855T3 (es) 2014-10-16 2021-03-02 Sage Therapeutics Inc Composiciones y métodos para tratar trastornos del SNC
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
HUE054092T2 (hu) 2015-01-26 2021-08-30 Sage Therapeutics Inc Központi idegrendszeri zavarok kezelésére szolgáló kompozíciók és eljárások
ES2935476T3 (es) 2015-02-20 2023-03-07 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
CA3030420A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
IL264129B2 (en) 2016-07-11 2024-05-01 Sage Therapeutics Inc C20, C17 and C21 converted neuroactive steroids and methods of using them
BR112021024033A2 (pt) 2019-05-31 2022-02-08 Sage Therapeutics Inc Esteroides neuroativos e suas composições

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451892A (en) * 1965-10-19 1969-06-24 Schering Corp Process for the preparation of steroidal compounds
NL6705450A (hu) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US3738983A (en) * 1971-08-06 1973-06-12 Searle & Co Process for the preparation of 3-(3beta,17beta-dihydroxyandrost-5-en-17alpha-yl) propionic acid gamma-lactone
DE2534911C2 (de) * 1975-08-01 1985-04-18 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 5-Androsten-17-on-Derivaten

Also Published As

Publication number Publication date
DD136142A5 (de) 1979-06-20
DK142372B (da) 1980-10-20
CH629503A5 (de) 1982-04-30
ATA504677A (de) 1980-12-15
IE45304B1 (en) 1982-07-28
FR2372176A1 (fr) 1978-06-23
IE45304L (en) 1978-01-16
DE2632677A1 (de) 1978-01-26
DD136141A5 (de) 1979-06-20
DK323677A (da) 1978-01-17
FR2372175A1 (fr) 1978-06-23
CS200517B2 (en) 1980-09-15
FR2372174A1 (fr) 1978-06-23
CH627190A5 (hu) 1981-12-31
CH629222A5 (de) 1982-04-15
JPS6117477B2 (hu) 1986-05-07
GB1585786A (en) 1981-03-11
AT363196B (de) 1981-07-10
SE440779B (sv) 1985-08-19
DK142372C (da) 1981-03-23
BE856860A (fr) 1978-01-16
SE7708192L (sv) 1978-01-17
HU182790B (en) 1984-03-28
FR2365588B1 (hu) 1982-06-25
YU164277A (en) 1982-08-31
US4179336A (en) 1979-12-18
HU182681B (en) 1984-02-28
DE2632677C2 (hu) 1988-06-16
HU182789B (en) 1984-03-28
DD132439A5 (de) 1978-09-27
SU980628A3 (ru) 1982-12-07
DD137235A5 (de) 1979-08-22
NL7706638A (nl) 1978-01-18
IT1077339B (it) 1985-05-04
FR2365588A1 (fr) 1978-04-21
JPS5315493A (en) 1978-02-13

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee
HRH9 Withdrawal of annulment decision
HMM4 Cancellation of final prot. due to non-payment of fee