FR2365588B1 - - Google Patents

Info

Publication number
FR2365588B1
FR2365588B1 FR7721932A FR7721932A FR2365588B1 FR 2365588 B1 FR2365588 B1 FR 2365588B1 FR 7721932 A FR7721932 A FR 7721932A FR 7721932 A FR7721932 A FR 7721932A FR 2365588 B1 FR2365588 B1 FR 2365588B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7721932A
Other versions
FR2365588A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of FR2365588A1 publication Critical patent/FR2365588A1/fr
Application granted granted Critical
Publication of FR2365588B1 publication Critical patent/FR2365588B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7721932A 1976-07-16 1977-07-18 Procede de preparation d'androstanones-17 Granted FR2365588A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762632677 DE2632677A1 (de) 1976-07-16 1976-07-16 Verfahren zur herstellung von androstan-17-on-derivaten und deren verwendung

Publications (2)

Publication Number Publication Date
FR2365588A1 FR2365588A1 (fr) 1978-04-21
FR2365588B1 true FR2365588B1 (fr) 1982-06-25

Family

ID=5983514

Family Applications (4)

Application Number Title Priority Date Filing Date
FR7721932A Granted FR2365588A1 (fr) 1976-07-16 1977-07-18 Procede de preparation d'androstanones-17
FR7806456A Pending FR2372174A1 (fr) 1976-07-16 1978-03-07 Procede de preparation d'alcoxy-3 hydroxy-17 androstanes
FR7806457A Pending FR2372176A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de derives d'alcoxy-3 androstanones-17
FR7806455A Pending FR2372175A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de l'hydroxy-3 androstanone-17 et de l'hydroxy-3 androstene-5 one-17

Family Applications After (3)

Application Number Title Priority Date Filing Date
FR7806456A Pending FR2372174A1 (fr) 1976-07-16 1978-03-07 Procede de preparation d'alcoxy-3 hydroxy-17 androstanes
FR7806457A Pending FR2372176A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de derives d'alcoxy-3 androstanones-17
FR7806455A Pending FR2372175A1 (fr) 1976-07-16 1978-03-07 Procede de preparation de l'hydroxy-3 androstanone-17 et de l'hydroxy-3 androstene-5 one-17

Country Status (18)

Country Link
US (1) US4179336A (fr)
JP (1) JPS5315493A (fr)
AT (1) AT363196B (fr)
BE (1) BE856860A (fr)
CH (3) CH627190A5 (fr)
CS (1) CS200517B2 (fr)
DD (4) DD136141A5 (fr)
DE (1) DE2632677A1 (fr)
DK (1) DK142372C (fr)
FR (4) FR2365588A1 (fr)
GB (1) GB1585786A (fr)
HU (4) HU182790B (fr)
IE (1) IE45304B1 (fr)
IT (1) IT1077339B (fr)
NL (1) NL7706638A (fr)
SE (1) SE440779B (fr)
SU (1) SU980628A3 (fr)
YU (1) YU164277A (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55148083A (en) * 1979-05-04 1980-11-18 Mitsubishi Chem Ind Ltd Microorganism
JPS55150893A (en) * 1979-05-11 1980-11-25 Mitsubishi Chem Ind Ltd Novel microorganism
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4755463A (en) * 1982-05-25 1988-07-05 Wisconsin Alumni Research Foundation Process for preparing steroids
US4444884A (en) * 1982-05-25 1984-04-24 Wisconsin Alumni Research Foundation Process for preparing steroids
JPH0512528Y2 (fr) * 1987-09-08 1993-03-31
DE69621281T2 (de) * 1995-02-28 2002-12-05 Nippon Shokubai Co., Ltd. Acryl-Säure-Derivate, Verfahren zur Herstellung von Acryl-Säure-Derivaten und Acryl-Säure-Polymere
PT2644206T (pt) * 2003-05-23 2019-07-10 Nektar Therapeutics Derivados de peg contendo duas cadeias de peg
EP2495242B1 (fr) * 2009-10-29 2016-05-04 Industry-Academic Cooperation Foundation Yonsei University Nouvel inhibiteur de fuite vasculaire
US9388210B2 (en) 2011-02-25 2016-07-12 Washington University Neuroactive 17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
CN108976272B (zh) 2011-10-14 2021-05-25 萨奇治疗股份有限公司 3,3-二取代的19-去甲孕甾烷化合物、组合物、及其用途
TR201808616T4 (tr) 2012-12-18 2018-07-23 Sage Therapeutics Inc Nöroaktif 19-alkoksi-17-ikameli steroidler, bunların ön ilaçları ve bunları kullanan tedavi yöntemleri.
US10202413B2 (en) 2013-02-15 2019-02-12 Washington University Neuroactive enantiomeric 15-, 16- and 17-substituted steroids as modulators for GABA type-A receptors
US9512170B2 (en) 2013-03-01 2016-12-06 Washington University Neuroactive 13, 17-substituted steroids as modulators for GABA type-A receptors
US9365502B2 (en) 2013-03-11 2016-06-14 Washington University Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors
US9562026B2 (en) 2013-03-14 2017-02-07 Washington University Neuroactive substituted cyclopent[a]anthracenes as modulators for GABA type-A receptors
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
HUE041369T2 (hu) 2013-04-17 2019-05-28 Sage Therapeutics Inc 19-nor C3,3-diszubsztituált C21-N-pirazolil-szteroidok és eljárás ezek alkalmazására
ES2807264T3 (es) 2013-04-17 2021-02-22 Sage Therapeutics Inc Esteroides neuroactivos 19-nor para métodos de tratamiento
CA3199003A1 (fr) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Steroides neuroactifs, compositions, et leurs utilisations
CA3235088A1 (fr) 2013-08-23 2015-02-26 Sage Therapeutics, Inc. Steroides neuroactifs, compositions et utilisations
WO2015195962A1 (fr) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations
US20170233433A1 (en) 2014-10-16 2017-08-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
MX2017005002A (es) 2014-10-16 2018-01-23 Sage Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos del snc.
EP3719029A1 (fr) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions pour l'induction de la sédation
RS61530B1 (sr) 2015-01-26 2021-04-29 Sage Therapeutics Inc Kompozicije i postupci za lečenje poremećaja cns
DK3258939T3 (da) 2015-02-20 2022-12-12 Sage Therapeutics Inc Neuroaktive steroider, sammensætninger og anvendelser heraf
IL309259A (en) 2016-07-11 2024-02-01 Sage Therapeutics Inc C17, C20 and C21 converted neuroactive steroids and methods of using them
JP7065825B2 (ja) 2016-07-11 2022-05-12 セージ セラピューティクス， インコーポレイテッド Ｃ７、ｃ１２、およびｃ１６置換神経刺激性ステロイドおよびそれらの使用方法
MA56046A (fr) 2019-05-31 2022-04-06 Sage Therapeutics Inc Stéroïdes neuroactifs et compositions associées

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451892A (en) * 1965-10-19 1969-06-24 Schering Corp Process for the preparation of steroidal compounds
NL6705450A (fr) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US3738983A (en) * 1971-08-06 1973-06-12 Searle & Co Process for the preparation of 3-(3beta,17beta-dihydroxyandrost-5-en-17alpha-yl) propionic acid gamma-lactone
DE2534911C2 (de) * 1975-08-01 1985-04-18 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung von 5-Androsten-17-on-Derivaten

Also Published As

Publication number Publication date
GB1585786A (en) 1981-03-11
HU179344B (en) 1982-10-28
SU980628A3 (ru) 1982-12-07
FR2365588A1 (fr) 1978-04-21
IT1077339B (it) 1985-05-04
FR2372176A1 (fr) 1978-06-23
IE45304B1 (en) 1982-07-28
FR2372175A1 (fr) 1978-06-23
CH627190A5 (fr) 1981-12-31
HU182681B (en) 1984-02-28
JPS6117477B2 (fr) 1986-05-07
ATA504677A (de) 1980-12-15
DK323677A (da) 1978-01-17
CH629503A5 (de) 1982-04-30
AT363196B (de) 1981-07-10
CS200517B2 (en) 1980-09-15
HU182789B (en) 1984-03-28
DD132439A5 (de) 1978-09-27
IE45304L (en) 1978-01-16
DK142372C (da) 1981-03-23
CH629222A5 (de) 1982-04-15
DK142372B (da) 1980-10-20
DD136142A5 (de) 1979-06-20
DD137235A5 (de) 1979-08-22
BE856860A (fr) 1978-01-16
DE2632677A1 (de) 1978-01-26
DE2632677C2 (fr) 1988-06-16
JPS5315493A (en) 1978-02-13
SE7708192L (sv) 1978-01-17
NL7706638A (nl) 1978-01-18
FR2372174A1 (fr) 1978-06-23
DD136141A5 (de) 1979-06-20
YU164277A (en) 1982-08-31
SE440779B (sv) 1985-08-19
US4179336A (en) 1979-12-18
HU182790B (en) 1984-03-28

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Legal Events

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ST Notification of lapse