BE893163A - Derives de cephalosporine, leur procede de preparation et leur application therapeutique - Google Patents

Derives de cephalosporine, leur procede de preparation et leur application therapeutique

Info

Publication number
BE893163A
BE893163A BE0/208075A BE208075A BE893163A BE 893163 A BE893163 A BE 893163A BE 0/208075 A BE0/208075 A BE 0/208075A BE 208075 A BE208075 A BE 208075A BE 893163 A BE893163 A BE 893163A
Authority
BE
Belgium
Prior art keywords
preparation process
therapeutic application
cephalosporin derivatives
cephalosporin
derivatives
Prior art date
Application number
BE0/208075A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of BE893163A publication Critical patent/BE893163A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
BE0/208075A 1981-05-12 1982-05-12 Derives de cephalosporine, leur procede de preparation et leur application therapeutique BE893163A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813118732 DE3118732A1 (de) 1981-05-12 1981-05-12 Cephalosporinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
BE893163A true BE893163A (fr) 1982-11-12

Family

ID=6132055

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/208075A BE893163A (fr) 1981-05-12 1982-05-12 Derives de cephalosporine, leur procede de preparation et leur application therapeutique

Country Status (36)

Country Link
US (1) US5071979A (fr)
EP (1) EP0064740B1 (fr)
JP (2) JPS57192394A (fr)
KR (1) KR880001541B1 (fr)
AR (1) AR241186A1 (fr)
AT (2) ATE19085T1 (fr)
AU (1) AU559727B2 (fr)
BE (1) BE893163A (fr)
BG (1) BG60838B2 (fr)
CA (1) CA1228850A (fr)
CH (1) CH654312A5 (fr)
CS (2) CS248025B2 (fr)
DD (1) DD202720A5 (fr)
DE (2) DE3118732A1 (fr)
DK (1) DK166500B1 (fr)
DZ (1) DZ418A1 (fr)
ES (1) ES8304143A1 (fr)
FI (1) FI70715C (fr)
FR (2) FR2511682B1 (fr)
GB (2) GB2098216A (fr)
GR (1) GR75506B (fr)
HU (1) HU186019B (fr)
IE (1) IE53296B1 (fr)
IL (1) IL65737A (fr)
IT (1) IT1157275B (fr)
LU (1) LU88736I2 (fr)
MA (1) MA19474A1 (fr)
MT (1) MTP909B (fr)
NL (3) NL8201913A (fr)
NO (2) NO162022C (fr)
NZ (1) NZ200567A (fr)
PH (1) PH20243A (fr)
PT (1) PT74877B (fr)
SE (1) SE8202961L (fr)
YU (1) YU44346B (fr)
ZA (1) ZA823226B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
RO84456B (ro) * 1981-09-08 1984-08-30 Eli Lilly And Co Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita
JPS5859991A (ja) * 1981-09-14 1983-04-09 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
EP0097961B1 (fr) * 1982-06-28 1987-11-11 Bristol-Myers Company Dérivés de céphalosporines, leur procédé de préparation et compositions pharmaceutiques les contenant
DE3247613A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3316798A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
DE3316797A1 (de) * 1983-05-07 1984-11-08 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von cephemverbindungen
US4690921A (en) * 1983-10-11 1987-09-01 Yamanouchi Pharmaceutical Co., Ltd. Cephalosporin compounds and salts thereof
GB2148289B (en) * 1983-10-17 1987-09-23 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
JPS6094984A (ja) * 1983-10-28 1985-05-28 Dai Ichi Seiyaku Co Ltd セフエム誘導体
GB8401093D0 (en) * 1984-01-16 1984-02-15 Fujisawa Pharmaceutical Co Cephem compounds
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
JPS60222490A (ja) * 1984-04-17 1985-11-07 Dai Ichi Seiyaku Co Ltd セフアロスポリン誘導体およびその塩
IL74822A (en) * 1984-04-17 1989-06-30 Daiichi Seiyaku Co Cephalosporin derivatives and salts thereof and their preparation
JPS60226884A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd セフアロスポリン誘導体
EP0160546A3 (fr) * 1984-04-26 1986-12-17 Yamanouchi Pharmaceutical Co. Ltd. Dérivés de céphalosporine, leur préparation et les médicaments les contenant
WO1985005106A1 (fr) * 1984-05-09 1985-11-21 Takeda Chemical Industries, Ltd. Composes cephem
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
JPH0613530B2 (ja) * 1984-06-08 1994-02-23 武田薬品工業株式会社 セフエム化合物
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
EP0238060B1 (fr) 1986-03-19 1992-01-08 Banyu Pharmaceutical Co., Ltd. Dérivés de céphalosporine, procédés pour leur préparation et agents antibactériens
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
JPH0242086A (ja) * 1988-08-02 1990-02-13 Banyu Pharmaceut Co Ltd （３‐ヒドロキシ‐４‐ピリドン‐１‐イル）メチル基を有する新規セファロスポリン誘導体
JPH02117679A (ja) * 1989-09-22 1990-05-02 Sankyo Co Ltd チアゾリオメチル置換基を有するセファロスポリン誘導体
US5594129A (en) * 1991-09-10 1997-01-14 Bristol-Myers Squibb Company Process for the preparation of a cephalosporin antibiotic
US5698703A (en) * 1991-09-10 1997-12-16 Bristol-Myers Squibb Company Syn-isomer of thiazolyl intermediate and process for the preparation thereof
EP0554004A3 (en) * 1992-01-27 1993-11-24 Katayama Seisakusho Cephem compounds and antibacterial agents
JPH0741485A (ja) * 1993-07-30 1995-02-10 Katayama Seiyakushiyo:Kk セフェム誘導体およびそれを含有する抗菌剤
WO1995032210A1 (fr) * 1994-05-23 1995-11-30 Korea Institute Of Science And Technology Composes de cephalosporine et leurs procedes de preparation
DE4440141A1 (de) 1994-11-10 1996-05-15 Hoechst Ag Neue kristalline Cephem-Säureadditionssalze und Verfahren zu ihrer Herstellung
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤
EP0893446B1 (fr) * 1996-04-04 2006-10-04 Shionogi & Co., Ltd. Composes de cephem et medicaments contenant ces composes
US5929086A (en) 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
KR100293728B1 (ko) * 1998-05-22 2001-09-17 손 경 식 결정성세피롬황산염의제조방법
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
ATE450540T1 (de) * 2003-05-23 2009-12-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
JP4754275B2 (ja) * 2005-06-13 2011-08-24 川崎重工業株式会社 壁掛機器用防振支持構造
EP2862569A1 (fr) 2011-09-09 2015-04-22 Cubist Pharmaceuticals, Inc. Procédés pour traiter des infections intrapulmonaires
CN102584856A (zh) * 2011-12-27 2012-07-18 开封豫港制药有限公司 硫酸头孢匹罗的制备方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
EP3100732A1 (fr) 2013-03-15 2016-12-07 Merck Sharp & Dohme Corp. Compositions antibiotiques de ceftolozane
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274990A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
EP3043797B1 (fr) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
JP6967000B2 (ja) * 2015-12-10 2021-11-17 ナエジャ−アールジーエム ファーマシューティカルズ ユーエルシー セフェム系化合物、それらの生成および使用
CN105646543B (zh) * 2016-03-17 2018-03-27 天津大学 一种头孢喹肟晶体及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082962A (en) * 1963-05-28 1967-09-13 Glaxo Lab Ltd Derivatives of 7-aminocephalosporanic acid
GB1052068A (fr) * 1963-11-04
GB1310642A (en) * 1970-11-09 1973-03-21 Pfizer Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4200746A (en) * 1974-12-20 1980-04-29 Glaxo Laboratories, Ltd. Cephalosporins
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
US4336353A (en) * 1979-09-11 1982-06-22 Ciba-Geigy Corporation Salts of 3-methyl-2-(2',4'-dimethyl-phenylimino)-4-thiazoline with polymers containing sulfonic acid groups
DE3069364D1 (en) * 1979-10-12 1984-11-08 Fujisawa Pharmaceutical Co Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR75644B (fr) * 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
US4367228A (en) * 1980-10-29 1983-01-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compound and composition
US4427677A (en) * 1980-12-31 1984-01-24 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
US4379787A (en) * 1981-10-02 1983-04-12 Eli Lilly And Company Oximino-substituted cephalosporin compounds
US4501739A (en) * 1982-01-19 1985-02-26 Eli Lilly And Company Thieno and furopyridinium-substituted cephalosporins
DE3248281A1 (de) * 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
DE3706020A1 (de) * 1987-02-25 1988-09-08 Hoechst Ag Kristallisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
YU98382A (en) 1985-08-31
NZ200567A (en) 1985-01-31
IE53296B1 (en) 1988-10-12
NL950013I2 (nl) 1997-02-03
JPH0144190B2 (fr) 1989-09-26
HU186019B (en) 1985-05-28
BG60838B2 (bg) 1996-04-30
ES511955A0 (es) 1983-02-16
AR241186A1 (es) 1992-01-31
US5071979A (en) 1991-12-10
IT8221182A0 (it) 1982-05-10
NL950013I1 (nl) 1997-02-03
CS415891A3 (en) 1992-04-15
AU8358982A (en) 1982-11-18
LU88736I2 (fr) 1996-08-23
CS248025B2 (en) 1987-01-15
FI821644A0 (fi) 1982-05-10
SE8202961L (sv) 1982-11-13
NO1999008I1 (no) 1999-05-27
DK211382A (da) 1982-11-13
CA1228850A (fr) 1987-11-03
PT74877B (de) 1984-11-26
FR2515654A1 (fr) 1983-05-06
FR2515654B1 (fr) 1986-11-14
IL65737A0 (en) 1982-08-31
EP0064740B1 (fr) 1986-04-09
ATA184382A (de) 1986-05-15
MTP909B (en) 1985-02-28
NO162022C (no) 1989-10-25
MA19474A1 (fr) 1982-12-31
FR2511682B1 (fr) 1985-06-28
SE8202961D0 (sv) 1982-05-11
PH20243A (en) 1986-11-10
ES8304143A1 (es) 1983-02-16
GB2144424B (en) 1986-02-12
DD202720A5 (de) 1983-09-28
KR880001541B1 (ko) 1988-08-20
JPH0670068B2 (ja) 1994-09-07
JPS6419082A (en) 1989-01-23
DE3270360D1 (en) 1986-05-15
IL65737A (en) 1986-11-30
NL940003I2 (nl) 1997-02-03
JPS57192394A (en) 1982-11-26
ATE19085T1 (de) 1986-04-15
FI70715C (fi) 1986-10-06
NL940003I1 (nl) 1994-04-05
AU559727B2 (en) 1987-03-19
IT1157275B (it) 1987-02-11
CH654312A5 (de) 1986-02-14
PT74877A (de) 1982-06-01
FI821644L (fi) 1982-11-13
FR2511682A1 (fr) 1983-02-25
GB2144424A (en) 1985-03-06
DE3118732A1 (de) 1982-12-02
GR75506B (fr) 1984-07-24
GB2098216A (en) 1982-11-17
FI70715B (fi) 1986-06-26
YU44346B (en) 1990-06-30
GB8423511D0 (en) 1984-10-24
ZA823226B (en) 1983-03-30
NO821562L (no) 1982-11-15
NO162022B (no) 1989-07-17
AT381945B (de) 1986-12-10
DK166500B1 (da) 1993-06-01
IE821129L (en) 1982-11-12
KR830010121A (ko) 1983-12-26
DZ418A1 (fr) 2004-09-13
EP0064740A3 (en) 1983-11-23
NL8201913A (nl) 1982-12-01
EP0064740A2 (fr) 1982-11-17

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: HOECHST A.G.

Effective date: 19870531