BE1002749A5 - Sels de cephalosporine, melanges contenant ces sels et procede de preparation du sel d'addition d'acide sulfurique. - Google Patents
Sels de cephalosporine, melanges contenant ces sels et procede de preparation du sel d'addition d'acide sulfurique. Download PDFInfo
- Publication number
- BE1002749A5 BE1002749A5 BE8900051A BE8900051A BE1002749A5 BE 1002749 A5 BE1002749 A5 BE 1002749A5 BE 8900051 A BE8900051 A BE 8900051A BE 8900051 A BE8900051 A BE 8900051A BE 1002749 A5 BE1002749 A5 BE 1002749A5
- Authority
- BE
- Belgium
- Prior art keywords
- salts
- preparation
- sulfuric acid
- mixtures containing
- acid added
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 title 2
- -1 CEPHALOSPORIN SALTS Chemical class 0.000 title 1
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 235000011007 phosphoric acid Nutrition 0.000 abstract 2
- HVFLCNVBZFFHBT-KTNPMIOTSA-N (6R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Chemical class NC=1SC=C(N=1)/C(/C(=O)NC1[C@@H]2N(C(=C(CS2)C[N+]2(CCCC2)C)C(=O)[O-])C1=O)=N/OC HVFLCNVBZFFHBT-KTNPMIOTSA-N 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Sels cristallins et stables à la température de 7-(alpha-(2-aminothiazol-4-yl)-alpha-(Z)-méthoxyiminoacétamido)-3-[(1-méthyl-1-pyrrolidinio)méthyl]-3-céphem-4-carboxylate choisis dans le groupe comprenant les sels d'addition d'acide sulfurique, di-nitrique, monochlorhydrique et dichlorhydrique, et les sels d'addition d'acide orthophosphorique contenant 1,5-2 équivalents molaires de H3PO4. Ces sels, mélangés avec certaines bases, donnent par dilution avec de l'eau des compositions pharmaceutiques injectables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/144,899 US4910301A (en) | 1985-08-05 | 1988-01-19 | Cefepime cephalosporin salts |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1002749A5 true BE1002749A5 (fr) | 1991-05-28 |
Family
ID=22510643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8900051A BE1002749A5 (fr) | 1988-01-19 | 1989-01-18 | Sels de cephalosporine, melanges contenant ces sels et procede de preparation du sel d'addition d'acide sulfurique. |
Country Status (32)
Country | Link |
---|---|
US (1) | US4910301A (fr) |
JP (1) | JPH0725768B2 (fr) |
KR (1) | KR950003612B1 (fr) |
AT (1) | AT399878B (fr) |
AU (1) | AU615509B2 (fr) |
BE (1) | BE1002749A5 (fr) |
CA (1) | CA1298288C (fr) |
CY (1) | CY1663A (fr) |
CZ (1) | CZ281602B6 (fr) |
DD (2) | DD283397A5 (fr) |
DE (1) | DE3901359A1 (fr) |
DK (1) | DK162054C (fr) |
EG (1) | EG18749A (fr) |
ES (1) | ES2012948A6 (fr) |
FI (1) | FI86854C (fr) |
FR (1) | FR2626003B1 (fr) |
GB (1) | GB2213819B (fr) |
GR (1) | GR1001218B (fr) |
HK (1) | HK72292A (fr) |
HU (1) | HU205940B (fr) |
IE (1) | IE67447B1 (fr) |
IT (1) | IT1229528B (fr) |
LU (1) | LU87432A1 (fr) |
NL (1) | NL192266C (fr) |
NZ (1) | NZ227605A (fr) |
OA (1) | OA09227A (fr) |
PT (1) | PT89474B (fr) |
SE (1) | SE505258C2 (fr) |
SG (1) | SG75492G (fr) |
SK (1) | SK281768B6 (fr) |
YU (1) | YU221188A (fr) |
ZA (1) | ZA89407B (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5244891A (en) * | 1985-08-05 | 1993-09-14 | Bristol-Myers Squibb Company | Injectable compositions of cefepime dihydrochloride hydrate |
DE68917574T2 (de) * | 1988-12-27 | 1994-12-15 | Chugai Pharmaceutical Co Ltd | Reinigungsverfahren für 1,2-Bis(nicotinamido)propan. |
CA2011116C (fr) * | 1989-03-06 | 1999-11-16 | Murray A. Kaplan | Dihydrochlorure de bmy-28142 lyophilise pour usage parenteral |
DE3919259A1 (de) * | 1989-06-13 | 1990-12-20 | Hoechst Ag | Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
US5698703A (en) * | 1991-09-10 | 1997-12-16 | Bristol-Myers Squibb Company | Syn-isomer of thiazolyl intermediate and process for the preparation thereof |
YU81692A (sh) * | 1991-09-10 | 1995-03-27 | Bristol-Myers Co. | Postupak za proizvodnju cefalosporinskog antibiotika |
US5594129A (en) * | 1991-09-10 | 1997-01-14 | Bristol-Myers Squibb Company | Process for the preparation of a cephalosporin antibiotic |
IL103110A (en) * | 1991-09-10 | 1997-04-15 | Bristol Myers Squibb Co | Anhydrous process for preparing cefepime dihydrochloride hydrate |
CA2099692C (fr) * | 1992-07-24 | 2003-09-30 | Gary M. F. Lim | Procede de preparation d'intermediaires de la cephalosporine |
CA2101571A1 (fr) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Dihydrate cristallise d'un sel de cephalosporine dihydrate; compositions injectables a base de ce compose |
US5391729A (en) * | 1992-09-08 | 1995-02-21 | Bristol-Myers Squibb Company | Crystalline dihydrate of a cephalosporin salt |
US5401842A (en) * | 1992-09-08 | 1995-03-28 | Bristol-Myers Squibb Company | Injectable compositions of a cephalosporin dihydrate salt |
JPH0840907A (ja) | 1994-08-03 | 1996-02-13 | Meiji Seika Kaisha Ltd | セファロスポリン注射剤 |
WO2005094800A2 (fr) * | 2004-03-31 | 2005-10-13 | Lupin Ltd. | Composition de cefepime co-precipite et procede de preparation correspondant |
EP1773845A1 (fr) * | 2004-07-16 | 2007-04-18 | Hetero Drugs Limited | Procede de preparation d'intermediaires de cephalosporine pures |
ITMI20051684A1 (it) * | 2005-09-13 | 2007-03-14 | Harvest Lodge Ltd | Procedimento per la produzione del dicloridrato di amminoacidi |
ITMI20060422A1 (it) * | 2006-03-09 | 2007-09-10 | Harvest Lodge Ltd | Procedimento diretto per la produzione del dicloridrato di un amminoacido |
US8151846B2 (en) * | 2006-12-15 | 2012-04-10 | Center Line Wheel Corporation | Wheel having inner bead-lock |
TWI400243B (zh) * | 2009-07-20 | 2013-07-01 | Intervet Int Bv | 製造西喹諾(cefquinome)粒子的方法 |
CN103304580B (zh) * | 2013-06-09 | 2014-07-09 | 四川省惠达药业有限公司 | 一种盐酸头孢吡肟化合物、其制备方法及其药物组合物 |
CN108463461B (zh) * | 2015-12-10 | 2021-11-19 | 奈加-Rgm制药有限公司 | 头孢烯化合物、其制备和用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2116180A (en) * | 1982-03-04 | 1983-09-21 | Bristol Myers Co | Cephalosporin derivatives |
FR2585705A1 (fr) * | 1985-08-05 | 1987-02-06 | Bristol Myers Co | Sels de cephalosporine et compositions injectables |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
JPS55151588A (en) * | 1979-05-14 | 1980-11-26 | Takeda Chem Ind Ltd | Preparation of cephalosporin salt crystal |
CH654010A5 (de) * | 1979-05-25 | 1986-01-31 | Glaxo Group Ltd | Zwischenprodukte zur verwendung bei der herstellung von cephalosporin-antibiotika. |
US4329453A (en) * | 1979-10-02 | 1982-05-11 | Glaxo Group Limited | Cephalosporin antibiotic |
US4406899A (en) * | 1982-03-04 | 1983-09-27 | Bristol-Myers Company | Cephalosporins |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
US4537959A (en) * | 1984-03-26 | 1985-08-27 | Eli Lilly And Company | Crystalline cephalosporin antibiotic salt |
US4751295A (en) * | 1984-04-09 | 1988-06-14 | Bristol-Myers Company | Cephalosporin derivatives |
US4749694A (en) * | 1984-04-26 | 1988-06-07 | Merck & Co., Inc. | Novel lysine esters used as absorption |
US4808617A (en) * | 1985-12-18 | 1989-02-28 | Bristol-Myers Company | Lyophilized or precipitated cephalosporin zwitterion and salt combination |
US4791196A (en) * | 1986-09-26 | 1988-12-13 | Sankyo Company Limited | Crystalline cephem carboxylic acid addition salt |
-
1988
- 1988-01-19 US US07/144,899 patent/US4910301A/en not_active Expired - Lifetime
- 1988-12-06 YU YU02211/88A patent/YU221188A/xx unknown
-
1989
- 1989-01-12 NZ NZ227605A patent/NZ227605A/en unknown
- 1989-01-13 SK SK243-89A patent/SK281768B6/sk unknown
- 1989-01-13 CZ CS89243A patent/CZ281602B6/cs not_active IP Right Cessation
- 1989-01-16 FI FI890213A patent/FI86854C/fi not_active IP Right Cessation
- 1989-01-16 ES ES8900146A patent/ES2012948A6/es not_active Expired - Fee Related
- 1989-01-17 GR GR890100025A patent/GR1001218B/el not_active IP Right Cessation
- 1989-01-17 IT IT8947539A patent/IT1229528B/it active
- 1989-01-18 PT PT89474A patent/PT89474B/pt not_active IP Right Cessation
- 1989-01-18 CA CA000588576A patent/CA1298288C/fr not_active Expired - Lifetime
- 1989-01-18 NL NL8900111A patent/NL192266C/nl not_active IP Right Cessation
- 1989-01-18 HU HU89185A patent/HU205940B/hu unknown
- 1989-01-18 LU LU87432A patent/LU87432A1/fr unknown
- 1989-01-18 EG EG2189A patent/EG18749A/xx active
- 1989-01-18 DD DD89325118A patent/DD283397A5/de unknown
- 1989-01-18 KR KR1019890000493A patent/KR950003612B1/ko not_active IP Right Cessation
- 1989-01-18 DE DE3901359A patent/DE3901359A1/de active Granted
- 1989-01-18 DD DD89333774A patent/DD284807A5/de unknown
- 1989-01-18 OA OA59509A patent/OA09227A/fr unknown
- 1989-01-18 ZA ZA89407A patent/ZA89407B/xx unknown
- 1989-01-18 GB GB8901073A patent/GB2213819B/en not_active Expired - Lifetime
- 1989-01-18 FR FR8900553A patent/FR2626003B1/fr not_active Expired - Lifetime
- 1989-01-18 DK DK020789A patent/DK162054C/da not_active IP Right Cessation
- 1989-01-18 AT AT0008589A patent/AT399878B/de not_active IP Right Cessation
- 1989-01-18 BE BE8900051A patent/BE1002749A5/fr active
- 1989-01-18 IE IE14489A patent/IE67447B1/en not_active IP Right Cessation
- 1989-01-18 SE SE8900173A patent/SE505258C2/sv not_active IP Right Cessation
- 1989-01-19 JP JP1008776A patent/JPH0725768B2/ja not_active Expired - Lifetime
- 1989-01-19 AU AU28623/89A patent/AU615509B2/en not_active Expired
-
1992
- 1992-07-24 SG SG754/92A patent/SG75492G/en unknown
- 1992-09-24 HK HK722/92A patent/HK72292A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1663A patent/CY1663A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2116180A (en) * | 1982-03-04 | 1983-09-21 | Bristol Myers Co | Cephalosporin derivatives |
FR2585705A1 (fr) * | 1985-08-05 | 1987-02-06 | Bristol Myers Co | Sels de cephalosporine et compositions injectables |
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS, vol. 108, no. 1, 4 janvier 1988, page 541, abrégé no. 5727a, Columbus, Ohio, US; J.E. SWIGOR et al.: "Synthesis of 7-[alpha-(2-aminothiazol-4-yl)-alpha-(Z)-methoximinoacetamido]-3-(1-[14C]methylpyrrolidinio)methyl-3-cephem-4-carboxyalate sulfate", & J. LABELLED COMPD. RADIOPHARM. 1987, 24(1), 15-22 * |
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