AU608531B2 - Advanced anticancer therapy and cytotoxic medicaments for its implementation - Google Patents

Advanced anticancer therapy and cytotoxic medicaments for its implementation Download PDF

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Publication number
AU608531B2
AU608531B2 AU77887/87A AU7788787A AU608531B2 AU 608531 B2 AU608531 B2 AU 608531B2 AU 77887/87 A AU77887/87 A AU 77887/87A AU 7788787 A AU7788787 A AU 7788787A AU 608531 B2 AU608531 B2 AU 608531B2
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AU
Australia
Prior art keywords
conjugate
composition
moiety
cells
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU77887/87A
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English (en)
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AU7788787A (en
Inventor
Daniel Bichon
Andrew Myers
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Battelle Memorial Institute Inc
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Battelle Memorial Institute Inc
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Filing date
Publication date
Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc
Publication of AU7788787A publication Critical patent/AU7788787A/en
Application granted granted Critical
Publication of AU608531B2 publication Critical patent/AU608531B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU77887/87A 1986-08-07 1987-08-05 Advanced anticancer therapy and cytotoxic medicaments for its implementation Expired - Fee Related AU608531B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP86810347 1986-08-07
EP86810347 1986-08-07

Publications (2)

Publication Number Publication Date
AU7788787A AU7788787A (en) 1988-02-24
AU608531B2 true AU608531B2 (en) 1991-04-11

Family

ID=8196463

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77887/87A Expired - Fee Related AU608531B2 (en) 1986-08-07 1987-08-05 Advanced anticancer therapy and cytotoxic medicaments for its implementation

Country Status (10)

Country Link
US (1) US5087616A (https=)
EP (1) EP0259904B1 (https=)
JP (1) JPH01500435A (https=)
AU (1) AU608531B2 (https=)
CA (1) CA1323303C (https=)
DE (1) DE3770730D1 (https=)
DK (1) DK184788A (https=)
FI (1) FI881579L (https=)
IN (1) IN165717B (https=)
WO (1) WO1988000837A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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AU657910B2 (en) * 1990-07-05 1995-03-30 Akzo N.V. Receptor directed-toxin conjugates
AU661819B2 (en) * 1990-03-02 1995-08-10 University Hospital, The Improved chimeric toxins

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WO1988000837A2 (en) 1988-02-11
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JPH01500435A (ja) 1989-02-16
DE3770730D1 (de) 1991-07-18
FI881579A7 (fi) 1988-04-06
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EP0259904B1 (en) 1991-06-12
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WO1988000837A3 (en) 1988-03-10
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US5087616A (en) 1992-02-11
CA1323303C (en) 1993-10-19
IN165717B (https=) 1989-12-23

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