AU601905B2 - Substituted benzthiazol-2-yl compounds as antitumor agents - Google Patents

Substituted benzthiazol-2-yl compounds as antitumor agents Download PDF

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Publication number
AU601905B2
AU601905B2 AU35098/89A AU3509889A AU601905B2 AU 601905 B2 AU601905 B2 AU 601905B2 AU 35098/89 A AU35098/89 A AU 35098/89A AU 3509889 A AU3509889 A AU 3509889A AU 601905 B2 AU601905 B2 AU 601905B2
Authority
AU
Australia
Prior art keywords
hydrogen
compound
fluoro
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35098/89A
Other languages
English (en)
Other versions
AU3509889A (en
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of AU3509889A publication Critical patent/AU3509889A/en
Application granted granted Critical
Publication of AU601905B2 publication Critical patent/AU601905B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU35098/89A 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents Ceased AU601905B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198034 1988-05-24

Publications (2)

Publication Number Publication Date
AU3509889A AU3509889A (en) 1989-11-30
AU601905B2 true AU601905B2 (en) 1990-09-20

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35098/89A Ceased AU601905B2 (en) 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents

Country Status (25)

Country Link
EP (1) EP0343893B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0678331B2 (cg-RX-API-DMAC7.html)
KR (1) KR910006864B1 (cg-RX-API-DMAC7.html)
CN (1) CN1023700C (cg-RX-API-DMAC7.html)
AT (1) ATE79114T1 (cg-RX-API-DMAC7.html)
AU (1) AU601905B2 (cg-RX-API-DMAC7.html)
CA (1) CA1328871C (cg-RX-API-DMAC7.html)
DD (1) DD283815A5 (cg-RX-API-DMAC7.html)
DE (1) DE68902358T2 (cg-RX-API-DMAC7.html)
DK (1) DK249389A (cg-RX-API-DMAC7.html)
ES (1) ES2043012T3 (cg-RX-API-DMAC7.html)
FI (1) FI892498A7 (cg-RX-API-DMAC7.html)
GR (1) GR3005844T3 (cg-RX-API-DMAC7.html)
HU (1) HU202507B (cg-RX-API-DMAC7.html)
IE (1) IE891667L (cg-RX-API-DMAC7.html)
IL (1) IL90337A0 (cg-RX-API-DMAC7.html)
MX (1) MX173140B (cg-RX-API-DMAC7.html)
MY (1) MY106035A (cg-RX-API-DMAC7.html)
NO (1) NO172389C (cg-RX-API-DMAC7.html)
NZ (1) NZ229234A (cg-RX-API-DMAC7.html)
PL (1) PL154875B1 (cg-RX-API-DMAC7.html)
PT (1) PT90622B (cg-RX-API-DMAC7.html)
SU (1) SU1681728A3 (cg-RX-API-DMAC7.html)
YU (1) YU47019B (cg-RX-API-DMAC7.html)
ZA (1) ZA893862B (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

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US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
PT850221E (pt) * 1995-08-30 2001-11-30 Searle & Co Derivados de meta-guanidina ureia tioureia ou acido aminobenzoico azaciclico como antagonistas de integrina
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
DE69833224T2 (de) 1997-11-10 2006-09-28 Bristol-Myers Squibb Co. Benzothiazole als protein tyrosin-kinase inhibitoren
EP0928793B1 (en) * 1998-01-02 2002-05-15 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
ATE385794T1 (de) 2000-06-21 2008-03-15 Hoffmann La Roche Benzothiazolderivate zur behandlung von alzheimer und parkinson
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
AU2004238508B2 (en) * 2003-05-13 2009-11-19 F. Hoffmann-La Roche Ag Imidazo-benzothiazoles
PL1636223T3 (pl) * 2003-05-19 2008-07-31 Hoffmann La Roche Pochodne benzotiazolu jako ligandy receptora adenozynowego
DE602004004776T2 (de) * 2003-05-21 2007-11-22 F. Hoffmann-La Roche Ag Benzothiazol derivate und ihre anwendung in der behandlung von adenosin a2a rezeptor vermittelten krankheiten #
CA2527174C (en) * 2003-05-30 2014-03-25 F.Hoffmann-La Roche Ag Benzothiazole derivatives and use thereof in the treatment of diseases related to the adenosine a2a receptor
KR20060054408A (ko) * 2003-07-28 2006-05-22 얀센 파마슈티카 엔.브이. 벤즈이미다졸, 벤즈티아졸 및 벤즈옥사졸 유도체 및ｌｔａ4 ｈ 조정자로서의 그의 용도
ATE382619T1 (de) 2004-05-24 2008-01-15 Hoffmann La Roche 4-hydroxy-4-methylpiperidin-1-carbonsäure-(4- methoxy-7-morpholin-4-ylbenzothiazol-2-yl)-amid
BRPI0513511A (pt) * 2004-07-22 2008-05-06 Hoffmann La Roche derivados de benzotiazol
EP1773795A1 (en) * 2004-07-22 2007-04-18 F.Hoffmann-La Roche Ag Substituted benzothiazoles
CN101056857B (zh) 2004-11-05 2010-12-01 弗·哈夫曼-拉罗切有限公司 异烟酸衍生物的制备方法
MX2007011483A (es) 2005-03-23 2007-10-12 Hoffmann La Roche Derivados de acetilenil-pirazolo-pirimidina como antagonistas de glutamato metabotropico 2.
AU2006298829B2 (en) 2005-09-27 2011-03-03 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists
CN101405278A (zh) * 2006-03-15 2009-04-08 4Sc股份公司 新颖的杂环NF-κB抑制剂
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
WO2013049407A2 (en) * 2011-09-30 2013-04-04 Kineta, Inc Anti-viral compounds
WO2013111875A1 (ja) 2012-01-27 2013-08-01 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
WO2015037706A1 (ja) * 2013-09-13 2015-03-19 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

Also Published As

Publication number Publication date
NO892059L (no) 1989-11-27
HUT51606A (en) 1990-05-28
MY106035A (en) 1995-03-31
CA1328871C (en) 1994-04-26
ATE79114T1 (de) 1992-08-15
NO172389C (no) 1993-07-14
IE891667L (en) 1989-11-24
FI892498A7 (fi) 1989-11-25
DK249389D0 (da) 1989-05-23
YU105989A (en) 1990-08-31
MX16158A (es) 1993-06-01
DE68902358D1 (de) 1992-09-10
MX173140B (es) 1994-02-02
ES2043012T3 (es) 1993-12-16
HU202507B (en) 1991-03-28
KR910006864B1 (ko) 1991-09-09
PT90622A (pt) 1989-11-30
DE68902358T2 (de) 1992-12-10
NO892059D0 (no) 1989-05-23
YU47019B (sh) 1994-11-15
KR890017248A (ko) 1989-12-15
DD283815A5 (de) 1990-10-24
JPH0678331B2 (ja) 1994-10-05
CN1023700C (zh) 1994-02-09
GR3005844T3 (cg-RX-API-DMAC7.html) 1993-06-07
EP0343893A1 (en) 1989-11-29
SU1681728A3 (ru) 1991-09-30
CN1037898A (zh) 1989-12-13
AU3509889A (en) 1989-11-30
FI892498A0 (fi) 1989-05-23
PT90622B (pt) 1994-10-31
NO172389B (no) 1993-04-05
NZ229234A (en) 1990-09-26
JPH0217181A (ja) 1990-01-22
PL279613A1 (en) 1989-11-27
EP0343893B1 (en) 1992-08-05
PL154875B1 (en) 1991-09-30
ZA893862B (en) 1991-01-30
IL90337A0 (en) 1989-12-15
DK249389A (da) 1989-11-27

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