AU532319B2 - Carbostyryl derivatives - Google Patents

Carbostyryl derivatives

Info

Publication number
AU532319B2
AU532319B2 AU59859/80A AU5985980A AU532319B2 AU 532319 B2 AU532319 B2 AU 532319B2 AU 59859/80 A AU59859/80 A AU 59859/80A AU 5985980 A AU5985980 A AU 5985980A AU 532319 B2 AU532319 B2 AU 532319B2
Authority
AU
Australia
Prior art keywords
dihydrocarbostyril
melting point
carbostyril
group
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU59859/80A
Other languages
English (en)
Other versions
AU5985980A (en
Inventor
T. Tanaka T. Nakagawa K. Nishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of AU5985980A publication Critical patent/AU5985980A/en
Application granted granted Critical
Publication of AU532319B2 publication Critical patent/AU532319B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AU59859/80A 1980-02-29 1980-06-04 Carbostyryl derivatives Ceased AU532319B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2565880A JPS56122356A (en) 1980-02-29 1980-02-29 Carbostyril derivative
JP55-25658 1980-02-29
PCT/JP1980/000122 WO1981002421A1 (fr) 1980-02-29 1980-06-04 Derive de carbostyrile

Publications (2)

Publication Number Publication Date
AU5985980A AU5985980A (en) 1981-09-11
AU532319B2 true AU532319B2 (en) 1983-09-22

Family

ID=12171902

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59859/80A Ceased AU532319B2 (en) 1980-02-29 1980-06-04 Carbostyryl derivatives

Country Status (24)

Country Link
US (1) US4435404A (enExample)
JP (1) JPS56122356A (enExample)
KR (2) KR860002099B1 (enExample)
AT (1) AT381493B (enExample)
AU (1) AU532319B2 (enExample)
BE (1) BE883713A (enExample)
CA (1) CA1159068A (enExample)
CH (1) CH647765A5 (enExample)
DE (1) DE3049959T1 (enExample)
DK (1) DK151956C (enExample)
ES (1) ES8105290A1 (enExample)
FI (1) FI76321C (enExample)
FR (1) FR2477149A1 (enExample)
GB (1) GB2070588B (enExample)
IT (1) IT1129812B (enExample)
MX (1) MX6752E (enExample)
NL (1) NL185146C (enExample)
NO (1) NO160512C (enExample)
PH (1) PH18532A (enExample)
PT (1) PT71359B (enExample)
SE (1) SE461147B (enExample)
SU (2) SU1169535A3 (enExample)
WO (1) WO1981002421A1 (enExample)
ZA (1) ZA803322B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
CA2093633A1 (en) * 1991-08-23 1993-02-24 Seiji Sato Carbostyril derivative and platelets aggregation inhibitory agent
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
TWI481601B (zh) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物
WO2011021676A1 (ja) 2009-08-21 2011-02-24 大塚製薬株式会社 ベンゾ［ｂ］［１，４］ジアゼピン－２，４－ジオン化合物の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021522A (en) * 1963-05-10 1966-03-02 Ici Ltd 2-quinolone derivatives
DE1527937A1 (de) * 1966-12-10 1969-11-13 Blanc & Co Verfahren zur Herstellung eines sich konisch verjuengenden,einen nach aussen abgewinkelten flachen Rand aufweisenden Hohlteils sowie Einrichtung zur Durchfuehrung des Verfahrens
JPS48103590A (enExample) * 1972-04-13 1973-12-25
JPS5082218A (enExample) * 1973-11-10 1975-07-03
JPS5310988B2 (enExample) * 1974-04-25 1978-04-18
JPS5318030B2 (enExample) * 1974-05-20 1978-06-13
FI59246C (fi) 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
US4313947A (en) 1974-06-24 1982-02-02 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS5273879A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of ester derivatives
JPS545981A (en) * 1977-06-10 1979-01-17 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives
NZ187452A (en) 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Also Published As

Publication number Publication date
DE3049959T1 (de) 1982-07-29
SU1169535A3 (ru) 1985-07-23
NO160512B (no) 1989-01-16
NO813477L (no) 1981-10-15
IT8067888A0 (it) 1980-06-06
SU1395140A3 (ru) 1988-05-07
FI76321B (fi) 1988-06-30
KR830002713A (ko) 1983-05-30
CH647765A5 (de) 1985-02-15
KR860002099B1 (ko) 1986-11-25
AT381493B (de) 1986-10-27
CA1159068A (en) 1983-12-20
FR2477149B1 (enExample) 1983-06-24
FI76321C (fi) 1988-10-10
DK250381A (da) 1981-09-03
NL8020199A (nl) 1981-12-01
ZA803322B (en) 1982-01-27
DE3049959C2 (enExample) 1993-07-08
MX6752E (es) 1986-06-25
AU5985980A (en) 1981-09-11
NO160512C (no) 1989-04-26
KR860002100B1 (ko) 1986-11-25
ES492230A0 (es) 1981-05-16
KR840004681A (ko) 1984-10-22
ATA909480A (de) 1986-03-15
PT71359B (en) 1981-10-21
PT71359A (en) 1980-07-01
ES8105290A1 (es) 1981-05-16
NL185146B (nl) 1989-09-01
DK151956C (da) 1988-08-15
PH18532A (en) 1985-08-09
BE883713A (fr) 1980-12-09
US4435404A (en) 1984-03-06
SE8102690L (sv) 1981-08-30
NL185146C (nl) 1990-02-01
WO1981002421A1 (fr) 1981-09-03
JPS6334845B2 (enExample) 1988-07-12
GB2070588A (en) 1981-09-09
FR2477149A1 (fr) 1981-09-04
GB2070588B (en) 1983-10-19
FI801843A7 (fi) 1981-08-30
DK151956B (da) 1988-01-18
IT1129812B (it) 1986-06-11
SE461147B (sv) 1990-01-15
JPS56122356A (en) 1981-09-25

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