NO813477L - Fremgangsmaate for fremstilling av karbostyrilderivater - Google Patents

Fremgangsmaate for fremstilling av karbostyrilderivater

Info

Publication number
NO813477L
NO813477L NO813477A NO813477A NO813477L NO 813477 L NO813477 L NO 813477L NO 813477 A NO813477 A NO 813477A NO 813477 A NO813477 A NO 813477A NO 813477 L NO813477 L NO 813477L
Authority
NO
Norway
Prior art keywords
carbostyric
derivatives
procedure
preparation
carbostyric derivatives
Prior art date
Application number
NO813477A
Other languages
English (en)
Other versions
NO160512C (no
NO160512B (no
Inventor
Takao Nishi
Tatsuyoshi Tanaka
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of NO813477L publication Critical patent/NO813477L/no
Publication of NO160512B publication Critical patent/NO160512B/no
Publication of NO160512C publication Critical patent/NO160512C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
NO81813477A 1980-02-29 1981-10-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater. NO160512C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2565880A JPS56122356A (en) 1980-02-29 1980-02-29 Carbostyril derivative
PCT/JP1980/000122 WO1981002421A1 (en) 1980-02-29 1980-06-04 Carbostyryl derivatives

Publications (3)

Publication Number Publication Date
NO813477L true NO813477L (no) 1981-10-15
NO160512B NO160512B (no) 1989-01-16
NO160512C NO160512C (no) 1989-04-26

Family

ID=12171902

Family Applications (1)

Application Number Title Priority Date Filing Date
NO81813477A NO160512C (no) 1980-02-29 1981-10-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.

Country Status (24)

Country Link
US (1) US4435404A (no)
JP (1) JPS56122356A (no)
KR (2) KR860002099B1 (no)
AT (1) AT381493B (no)
AU (1) AU532319B2 (no)
BE (1) BE883713A (no)
CA (1) CA1159068A (no)
CH (1) CH647765A5 (no)
DE (1) DE3049959T1 (no)
DK (1) DK151956C (no)
ES (1) ES492230A0 (no)
FI (1) FI76321C (no)
FR (1) FR2477149A1 (no)
GB (1) GB2070588B (no)
IT (1) IT1129812B (no)
MX (1) MX6752E (no)
NL (1) NL185146C (no)
NO (1) NO160512C (no)
PH (1) PH18532A (no)
PT (1) PT71359B (no)
SE (1) SE461147B (no)
SU (2) SU1169535A3 (no)
WO (1) WO1981002421A1 (no)
ZA (1) ZA803322B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
AU653060B2 (en) * 1991-08-23 1994-09-15 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative and platelet agglutination inhibitor
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−3,4−ジヒドロカルボスチリル誘導体
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
KR20120065360A (ko) 2009-08-21 2012-06-20 오츠카 세이야쿠 가부시키가이샤 벤조[b][1,4]디아제핀-2,4-디온 화합물의 제조 방법
TWI481601B (zh) * 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd 含氮化合物及藥學組成物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021522A (en) * 1963-05-10 1966-03-02 Ici Ltd 2-quinolone derivatives
DE1527937A1 (de) * 1966-12-10 1969-11-13 Blanc & Co Verfahren zur Herstellung eines sich konisch verjuengenden,einen nach aussen abgewinkelten flachen Rand aufweisenden Hohlteils sowie Einrichtung zur Durchfuehrung des Verfahrens
JPS517672B2 (no) * 1972-04-13 1976-03-10
JPS5082218A (no) * 1973-11-10 1975-07-03
JPS5310988B2 (no) * 1974-04-25 1978-04-18
JPS5318030B2 (no) * 1974-05-20 1978-06-13
US4313947A (en) 1974-06-24 1982-02-02 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
US4070470A (en) 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS5273879A (en) * 1975-12-18 1977-06-21 Otsuka Pharmaceut Co Ltd Synthesis of ester derivatives
JPS545981A (en) * 1977-06-10 1979-01-17 Otsuka Pharmaceut Co Ltd Carbostyryl derivatives
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation

Also Published As

Publication number Publication date
GB2070588A (en) 1981-09-09
NL185146C (nl) 1990-02-01
BE883713A (fr) 1980-12-09
IT1129812B (it) 1986-06-11
KR860002099B1 (ko) 1986-11-25
NL185146B (nl) 1989-09-01
SU1169535A3 (ru) 1985-07-23
DK151956C (da) 1988-08-15
KR830002713A (ko) 1983-05-30
KR860002100B1 (ko) 1986-11-25
SE461147B (sv) 1990-01-15
JPS56122356A (en) 1981-09-25
FR2477149A1 (fr) 1981-09-04
GB2070588B (en) 1983-10-19
ES8105290A1 (es) 1981-05-16
NL8020199A (nl) 1981-12-01
AU532319B2 (en) 1983-09-22
DK151956B (da) 1988-01-18
PT71359B (en) 1981-10-21
IT8067888A0 (it) 1980-06-06
DE3049959C2 (no) 1993-07-08
PH18532A (en) 1985-08-09
NO160512C (no) 1989-04-26
CH647765A5 (de) 1985-02-15
SU1395140A3 (ru) 1988-05-07
PT71359A (en) 1980-07-01
NO160512B (no) 1989-01-16
FR2477149B1 (no) 1983-06-24
SE8102690L (sv) 1981-08-30
JPS6334845B2 (no) 1988-07-12
FI76321C (fi) 1988-10-10
DK250381A (da) 1981-09-03
KR840004681A (ko) 1984-10-22
FI801843A (fi) 1981-08-30
AU5985980A (en) 1981-09-11
DE3049959T1 (de) 1982-07-29
FI76321B (fi) 1988-06-30
AT381493B (de) 1986-10-27
CA1159068A (en) 1983-12-20
US4435404A (en) 1984-03-06
ATA909480A (de) 1986-03-15
ZA803322B (en) 1982-01-27
ES492230A0 (es) 1981-05-16
MX6752E (es) 1986-06-25
WO1981002421A1 (en) 1981-09-03

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