DK250381A - Carbostyrilderivater og fremgangsmaade til fremstilling deraf - Google Patents
Carbostyrilderivater og fremgangsmaade til fremstilling derafInfo
- Publication number
- DK250381A DK250381A DK250381A DK250381A DK250381A DK 250381 A DK250381 A DK 250381A DK 250381 A DK250381 A DK 250381A DK 250381 A DK250381 A DK 250381A DK 250381 A DK250381 A DK 250381A
- Authority
- DK
- Denmark
- Prior art keywords
- procedures
- preparing
- carbostyril derivatives
- carbostyril
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2565880A JPS56122356A (en) | 1980-02-29 | 1980-02-29 | Carbostyril derivative |
| JP2565880 | 1980-02-29 | ||
| JP8000122 | 1980-06-04 | ||
| PCT/JP1980/000122 WO1981002421A1 (en) | 1980-02-29 | 1980-06-04 | Carbostyryl derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK250381A true DK250381A (da) | 1981-09-03 |
| DK151956B DK151956B (da) | 1988-01-18 |
| DK151956C DK151956C (da) | 1988-08-15 |
Family
ID=12171902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK250381A DK151956C (da) | 1980-02-29 | 1981-06-09 | Analogifremgangsmaade til fremstilling af carbostyrilderivater |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4435404A (da) |
| JP (1) | JPS56122356A (da) |
| KR (2) | KR860002099B1 (da) |
| AT (1) | AT381493B (da) |
| AU (1) | AU532319B2 (da) |
| BE (1) | BE883713A (da) |
| CA (1) | CA1159068A (da) |
| CH (1) | CH647765A5 (da) |
| DE (1) | DE3049959T1 (da) |
| DK (1) | DK151956C (da) |
| ES (1) | ES8105290A1 (da) |
| FI (1) | FI76321C (da) |
| FR (1) | FR2477149A1 (da) |
| GB (1) | GB2070588B (da) |
| IT (1) | IT1129812B (da) |
| MX (1) | MX6752E (da) |
| NL (1) | NL185146C (da) |
| NO (1) | NO160512C (da) |
| PH (1) | PH18532A (da) |
| PT (1) | PT71359B (da) |
| SE (1) | SE461147B (da) |
| SU (2) | SU1169535A3 (da) |
| WO (1) | WO1981002421A1 (da) |
| ZA (1) | ZA803322B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI80022C (fi) * | 1982-07-05 | 1990-04-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat. |
| DE3434271A1 (de) * | 1984-09-19 | 1986-03-20 | Beiersdorf Ag, 2000 Hamburg | Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
| US5227381A (en) * | 1988-05-02 | 1993-07-13 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative |
| JP2753622B2 (ja) | 1988-05-02 | 1998-05-20 | 大塚製薬株式会社 | カルボスチリル誘導体 |
| US5506239A (en) * | 1991-08-23 | 1996-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivative and platelets aggregation inhibitory agent |
| JP2686887B2 (ja) * | 1992-08-11 | 1997-12-08 | キッセイ薬品工業株式会社 | ピペリジノ−３，４−ジヒドロカルボスチリル誘導体 |
| US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
| IN2012DN00986A (da) | 2009-08-21 | 2015-04-10 | Otsuka Pharma Co Ltd | |
| TWI481601B (zh) * | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1021522A (en) * | 1963-05-10 | 1966-03-02 | Ici Ltd | 2-quinolone derivatives |
| DE1527937A1 (de) * | 1966-12-10 | 1969-11-13 | Blanc & Co | Verfahren zur Herstellung eines sich konisch verjuengenden,einen nach aussen abgewinkelten flachen Rand aufweisenden Hohlteils sowie Einrichtung zur Durchfuehrung des Verfahrens |
| JPS48103590A (da) * | 1972-04-13 | 1973-12-25 | ||
| JPS5082218A (da) * | 1973-11-10 | 1975-07-03 | ||
| JPS5310988B2 (da) * | 1974-04-25 | 1978-04-18 | ||
| JPS5318030B2 (da) * | 1974-05-20 | 1978-06-13 | ||
| US4070470A (en) * | 1974-06-24 | 1978-01-24 | Otsuka Pharmaceutical Co., Ltd. | Platelet aggregation inhibiting carbostyrils, their compositions and method of use |
| US4313947A (en) | 1974-06-24 | 1982-02-02 | Otsuka Pharmaceutical Co., Ltd. | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use |
| US4081447A (en) * | 1975-04-09 | 1978-03-28 | Abbott Laboratories | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
| JPS5273879A (en) * | 1975-12-18 | 1977-06-21 | Otsuka Pharmaceut Co Ltd | Synthesis of ester derivatives |
| JPS545981A (en) * | 1977-06-10 | 1979-01-17 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivatives |
| NZ187452A (en) * | 1977-06-10 | 1980-05-27 | Otsuka Pharma Co Ltd | N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation |
-
1980
- 1980-02-29 JP JP2565880A patent/JPS56122356A/ja active Granted
- 1980-06-04 US US06/261,177 patent/US4435404A/en not_active Expired - Fee Related
- 1980-06-04 ZA ZA00803322A patent/ZA803322B/xx unknown
- 1980-06-04 DE DE803049959T patent/DE3049959T1/de active Granted
- 1980-06-04 AU AU59859/80A patent/AU532319B2/en not_active Ceased
- 1980-06-04 NL NLAANVRAGE8020199,A patent/NL185146C/xx not_active IP Right Cessation
- 1980-06-04 WO PCT/JP1980/000122 patent/WO1981002421A1/ja active Application Filing
- 1980-06-04 AT AT0909480A patent/AT381493B/de not_active IP Right Cessation
- 1980-06-04 PH PH24106A patent/PH18532A/en unknown
- 1980-06-04 CH CH6674/81A patent/CH647765A5/de not_active IP Right Cessation
- 1980-06-05 KR KR1019800002229A patent/KR860002099B1/ko active
- 1980-06-06 CA CA000353541A patent/CA1159068A/en not_active Expired
- 1980-06-06 IT IT67888/80A patent/IT1129812B/it active
- 1980-06-06 PT PT71359A patent/PT71359B/pt unknown
- 1980-06-06 ES ES492230A patent/ES8105290A1/es not_active Expired
- 1980-06-06 MX MX808865U patent/MX6752E/es unknown
- 1980-06-06 GB GB8018609A patent/GB2070588B/en not_active Expired
- 1980-06-09 FR FR8012744A patent/FR2477149A1/fr active Granted
- 1980-06-09 FI FI801843A patent/FI76321C/fi not_active IP Right Cessation
- 1980-06-09 BE BE0/200953A patent/BE883713A/fr not_active IP Right Cessation
-
1981
- 1981-04-29 SE SE8102690A patent/SE461147B/sv not_active IP Right Cessation
- 1981-05-11 SU SU813280901A patent/SU1169535A3/ru active
- 1981-06-09 DK DK250381A patent/DK151956C/da not_active IP Right Cessation
- 1981-10-15 NO NO81813477A patent/NO160512C/no unknown
-
1982
- 1982-06-18 SU SU823456112A patent/SU1395140A3/ru active
-
1984
- 1984-05-29 KR KR1019840002957A patent/KR860002100B1/ko not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |