AU3741801A - Substituted beta-carbolines with ikb-kinase inhibiting activity - Google Patents

Substituted beta-carbolines with ikb-kinase inhibiting activity

Info

Publication number
AU3741801A
AU3741801A AU3741801A AU3741801A AU3741801A AU 3741801 A AU3741801 A AU 3741801A AU 3741801 A AU3741801 A AU 3741801A AU 3741801 A AU3741801 A AU 3741801A AU 3741801 A AU3741801 A AU 3741801A
Authority
AU
Australia
Prior art keywords
carbolines
ikb
substituted beta
inhibiting activity
kinase inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU3741801A
Other languages
English (en)
Inventor
Olaf Ritzeler
Alfredo Castro
Louis Grenier
Francois Soucy
Wayne W Hancock
Hormoz Mazdiyasni
Vito Palombella
Julian Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00105514A external-priority patent/EP1134221A1/en
Priority claimed from EP00125169A external-priority patent/EP1209158A1/en
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority claimed from PCT/EP2001/002237 external-priority patent/WO2001068648A1/en
Publication of AU3741801A publication Critical patent/AU3741801A/xx
Pending legal-status Critical Current

Links

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
AU3741801A 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity Pending AU3741801A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00105514A EP1134221A1 (en) 2000-03-15 2000-03-15 Substituted beta-carbolines as lkB kinase inhibitors
EP00125169A EP1209158A1 (en) 2000-11-18 2000-11-18 Substituted beta-carbolines
PCT/EP2001/002237 WO2001068648A1 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Publications (1)

Publication Number Publication Date
AU3741801A true AU3741801A (en) 2001-09-24

Family

ID=26070675

Family Applications (2)

Application Number Title Priority Date Filing Date
AU3741801A Pending AU3741801A (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity
AU2001237418A Ceased AU2001237418B2 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001237418A Ceased AU2001237418B2 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Country Status (23)

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US (3) US6627637B2 (https=)
JP (1) JP5000828B2 (https=)
KR (1) KR100826817B1 (https=)
CN (1) CN100509810C (https=)
AT (1) ATE465161T1 (https=)
AU (2) AU3741801A (https=)
BR (1) BR0109161A (https=)
CA (1) CA2402549A1 (https=)
CZ (1) CZ301077B6 (https=)
DE (1) DE60141895D1 (https=)
EE (1) EE200200523A (https=)
HK (1) HK1054039B (https=)
HR (1) HRP20020748A2 (https=)
HU (1) HUP0300894A3 (https=)
IL (2) IL151695A0 (https=)
ME (1) MEP28108A (https=)
MX (1) MXPA02007981A (https=)
NO (1) NO324248B1 (https=)
NZ (1) NZ521386A (https=)
PL (1) PL357284A1 (https=)
RU (1) RU2277095C2 (https=)
SK (1) SK13082002A3 (https=)
YU (1) YU65502A (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002247059B2 (en) * 2001-02-01 2006-11-16 Bristol-Myers Squibb Company Method of treating inflammatory and immune diseases using inhibitors of IkappaB kinase (IKK)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1054039B (zh) * 2000-03-15 2010-04-16 萨诺费－阿文蒂斯德国有限公司 取代的β-咔啉
US9248124B2 (en) * 2001-11-07 2016-02-02 Millennium Pharmaceuticals, Inc. Use of inhibitors of IκB kinase for the treatment of cancer
US7462638B2 (en) * 2002-08-17 2008-12-09 Sanofi-Aventis Deutschland Gmbh Use of IκB-kinase inhibitors in pain therapy
US20040166095A1 (en) * 2003-02-25 2004-08-26 Blazar Bruce R. Methods for preventing GVHD
BRPI0409263A (pt) * 2003-04-09 2006-03-28 Millennium Pharm Inc composto; composição farmacêutica; método para tratar uma doença mediada por ikk e método para inibir ikk em um paciente que dele necessita
BRPI0509660A (pt) * 2004-04-09 2007-10-09 Millennium Pharm Inc compostos de beta-carbolina de utilidade no tratamento de doenças inflamatórias
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