NO20024338L - Substituerte beta-karboliner med IKB-kinaseinhiberende aktivitet - Google Patents

Substituerte beta-karboliner med IKB-kinaseinhiberende aktivitet

Info

Publication number
NO20024338L
NO20024338L NO20024338A NO20024338A NO20024338L NO 20024338 L NO20024338 L NO 20024338L NO 20024338 A NO20024338 A NO 20024338A NO 20024338 A NO20024338 A NO 20024338A NO 20024338 L NO20024338 L NO 20024338L
Authority
NO
Norway
Prior art keywords
inhibitory activity
substituted beta
kinase inhibitory
ikb kinase
carbolines
Prior art date
Application number
NO20024338A
Other languages
English (en)
Other versions
NO20024338D0 (no
NO324248B1 (no
Inventor
Olaf Ritzeler
Alfredo Castro
Louis Grenier
Francois Soucy
Wayne W Hancock
Hormoz Mazdiyasni
Vito Palombella
Julian Adams
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00105514A external-priority patent/EP1134221A1/en
Priority claimed from EP00125169A external-priority patent/EP1209158A1/en
Priority claimed from PCT/EP2001/002237 external-priority patent/WO2001068648A1/en
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20024338D0 publication Critical patent/NO20024338D0/no
Publication of NO20024338L publication Critical patent/NO20024338L/no
Publication of NO324248B1 publication Critical patent/NO324248B1/no

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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NO20024338A 2000-03-15 2002-09-11 Substituerte beta-karboliner med IKB-kinaseinhiberende aktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytikum inneholdende minst en slik forbindelse NO324248B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00105514A EP1134221A1 (en) 2000-03-15 2000-03-15 Substituted beta-carbolines as lkB kinase inhibitors
EP00125169A EP1209158A1 (en) 2000-11-18 2000-11-18 Substituted beta-carbolines
PCT/EP2001/002237 WO2001068648A1 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Publications (3)

Publication Number Publication Date
NO20024338D0 NO20024338D0 (no) 2002-09-11
NO20024338L true NO20024338L (no) 2002-11-05
NO324248B1 NO324248B1 (no) 2007-09-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20024338A NO324248B1 (no) 2000-03-15 2002-09-11 Substituerte beta-karboliner med IKB-kinaseinhiberende aktivitet, fremgangsmate for fremstilling derav, anvendelse derav samt farmasoytikum inneholdende minst en slik forbindelse

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US (3) US6627637B2 (no)
JP (1) JP5000828B2 (no)
KR (1) KR100826817B1 (no)
CN (1) CN100509810C (no)
AT (1) ATE465161T1 (no)
AU (2) AU3741801A (no)
BR (1) BR0109161A (no)
CA (1) CA2402549A1 (no)
CZ (1) CZ301077B6 (no)
DE (1) DE60141895D1 (no)
EE (1) EE200200523A (no)
HK (1) HK1054039B (no)
HR (1) HRP20020748A2 (no)
HU (1) HUP0300894A3 (no)
IL (2) IL151695A0 (no)
ME (1) MEP28108A (no)
MX (1) MXPA02007981A (no)
NO (1) NO324248B1 (no)
NZ (1) NZ521386A (no)
PL (1) PL357284A1 (no)
RU (1) RU2277095C2 (no)
SK (1) SK13082002A3 (no)
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0300894A3 (en) * 2000-03-15 2008-05-28 Sanofi Aventis Deutschland Substituted beta-carbolines, process for their preparation, pharmaceutical compositions containing them and their use
HUP0304045A3 (en) * 2001-02-01 2005-05-30 Bristol Myers Squibb Company P Use of ikb-kinase inhibitors for treating of inflammatory and immune diseases and pharmaceutical compositions containing them
AU2002352498A1 (en) * 2001-11-07 2003-05-19 Millennium Pharmaceuticals, Inc. Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma and others cancers
US7462638B2 (en) * 2002-08-17 2008-12-09 Sanofi-Aventis Deutschland Gmbh Use of IκB-kinase inhibitors in pain therapy
US20040166095A1 (en) * 2003-02-25 2004-08-26 Blazar Bruce R. Methods for preventing GVHD
KR20060006031A (ko) * 2003-04-09 2006-01-18 밀레니엄 파머슈티컬스 인코퍼레이티드 염증 질환 치료에 유용한 베타-카르볼린
UA88638C2 (ru) * 2004-04-09 2009-11-10 Милленниум Фармасьютикалз, Инк. Бета-карболины, полезные для лечения воспалительного заболевания
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