NO20080417L - Benzosykloheptapyridiner som inhibitorer av reseptortyrosinkinasen MET - Google Patents
Benzosykloheptapyridiner som inhibitorer av reseptortyrosinkinasen METInfo
- Publication number
- NO20080417L NO20080417L NO20080417A NO20080417A NO20080417L NO 20080417 L NO20080417 L NO 20080417L NO 20080417 A NO20080417 A NO 20080417A NO 20080417 A NO20080417 A NO 20080417A NO 20080417 L NO20080417 L NO 20080417L
- Authority
- NO
- Norway
- Prior art keywords
- tyrosine kinase
- receptor tyrosine
- benzocycloheptapyridines
- inhibitors
- kinase met
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Den foreliggende oppfinnelse vedrører 5H-benzo[4,5]syklohepta[1,2-b]pyridinderivater som er anvendbare til behandling av cellulære proliferative sykdommer, til behandling av forstyrrelser forbundet med MET-aktivitet, og til inhibering av reseptortyrosinkinasen MET. Oppfinnelsen vedrører også preparater som omfatter disse forbindelsene, og fremgangsmåter for anvendelse av dem til å behandle kreft hos pattedyr.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69322905P | 2005-06-23 | 2005-06-23 | |
US72906105P | 2005-10-21 | 2005-10-21 | |
US78947306P | 2006-04-05 | 2006-04-05 | |
PCT/US2006/024256 WO2007002258A2 (en) | 2005-06-23 | 2006-06-22 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20080417L true NO20080417L (no) | 2008-03-18 |
Family
ID=37595817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20080417A NO20080417L (no) | 2005-06-23 | 2008-01-22 | Benzosykloheptapyridiner som inhibitorer av reseptortyrosinkinasen MET |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1896422B1 (no) |
KR (1) | KR20080018907A (no) |
AR (1) | AR057377A1 (no) |
AT (1) | ATE520664T1 (no) |
BR (1) | BRPI0612518A2 (no) |
CR (1) | CR9579A (no) |
CY (1) | CY1112038T1 (no) |
DO (1) | DOP2006000143A (no) |
EC (1) | ECSP078017A (no) |
IL (1) | IL187895A0 (no) |
MA (1) | MA29643B1 (no) |
MX (1) | MX2007016533A (no) |
NI (1) | NI200700318A (no) |
NO (1) | NO20080417L (no) |
NZ (1) | NZ563711A (no) |
PE (1) | PE20070167A1 (no) |
PL (1) | PL1896422T3 (no) |
PT (1) | PT1896422E (no) |
SI (1) | SI1896422T1 (no) |
TW (1) | TW200738638A (no) |
WO (1) | WO2007002258A2 (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200813021A (en) * | 2006-07-10 | 2008-03-16 | Merck & Co Inc | Tyrosine kinase inhibitors |
US7893081B2 (en) * | 2007-12-20 | 2011-02-22 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
EP2482821A4 (en) | 2009-09-30 | 2013-03-06 | Merck Sharp & Dohme | CRYSTALLINE HYDROCHLORIDE SALTS FROM C-MET KINASE INHIBITORS |
WO2011039527A1 (en) | 2009-09-30 | 2011-04-07 | Merck Sharp & Dohme Ltd | Formulations for c-met kinase inhibitors |
JP2013532627A (ja) | 2010-07-01 | 2013-08-19 | 武田薬品工業株式会社 | cMET阻害剤とHGFおよび/またはcMETに対する抗体との組み合わせ |
US10398774B2 (en) | 2014-12-09 | 2019-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Human monoclonal antibodies against AXL |
WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04002682A (es) * | 2001-09-19 | 2004-06-18 | Pharmacia Corp | Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion. |
WO2003084931A1 (en) * | 2002-04-02 | 2003-10-16 | Merck & Co., Inc. | 5h-benzo[4,5]cyclohepta[1,2-b]pyridine nmda/nr2b antagonists |
-
2006
- 2006-06-14 TW TW095121232A patent/TW200738638A/zh unknown
- 2006-06-16 AR ARP060102571A patent/AR057377A1/es not_active Application Discontinuation
- 2006-06-21 PE PE2006000702A patent/PE20070167A1/es not_active Application Discontinuation
- 2006-06-22 AT AT06785319T patent/ATE520664T1/de active
- 2006-06-22 MX MX2007016533A patent/MX2007016533A/es unknown
- 2006-06-22 SI SI200631136T patent/SI1896422T1/sl unknown
- 2006-06-22 PT PT06785319T patent/PT1896422E/pt unknown
- 2006-06-22 EP EP06785319A patent/EP1896422B1/en active Active
- 2006-06-22 KR KR1020077030202A patent/KR20080018907A/ko not_active Application Discontinuation
- 2006-06-22 BR BRPI0612518-2A patent/BRPI0612518A2/pt not_active IP Right Cessation
- 2006-06-22 NZ NZ563711A patent/NZ563711A/en not_active IP Right Cessation
- 2006-06-22 WO PCT/US2006/024256 patent/WO2007002258A2/en active Application Filing
- 2006-06-22 PL PL06785319T patent/PL1896422T3/pl unknown
- 2006-06-23 DO DO2006000143A patent/DOP2006000143A/es unknown
-
2007
- 2007-12-04 NI NI200700318A patent/NI200700318A/es unknown
- 2007-12-04 IL IL187895A patent/IL187895A0/en unknown
- 2007-12-07 CR CR9579A patent/CR9579A/es not_active Application Discontinuation
- 2007-12-14 EC EC2007008017A patent/ECSP078017A/es unknown
-
2008
- 2008-01-22 NO NO20080417A patent/NO20080417L/no not_active Application Discontinuation
- 2008-01-23 MA MA30591A patent/MA29643B1/fr unknown
-
2011
- 2011-11-16 CY CY20111101099T patent/CY1112038T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PE20070167A1 (es) | 2007-04-16 |
CY1112038T1 (el) | 2015-11-04 |
ATE520664T1 (de) | 2011-09-15 |
TW200738638A (en) | 2007-10-16 |
EP1896422B1 (en) | 2011-08-17 |
ECSP078017A (es) | 2008-01-23 |
IL187895A0 (en) | 2008-03-20 |
WO2007002258A3 (en) | 2007-06-07 |
KR20080018907A (ko) | 2008-02-28 |
PT1896422E (pt) | 2011-11-08 |
DOP2006000143A (es) | 2007-02-28 |
EP1896422A2 (en) | 2008-03-12 |
SI1896422T1 (sl) | 2011-11-30 |
NI200700318A (es) | 2008-05-23 |
PL1896422T3 (pl) | 2012-01-31 |
CR9579A (es) | 2008-03-06 |
BRPI0612518A2 (pt) | 2010-11-23 |
WO2007002258A2 (en) | 2007-01-04 |
NZ563711A (en) | 2010-12-24 |
AR057377A1 (es) | 2007-11-28 |
MX2007016533A (es) | 2008-03-06 |
MA29643B1 (fr) | 2008-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20080417L (no) | Benzosykloheptapyridiner som inhibitorer av reseptortyrosinkinasen MET | |
DK1896421T3 (da) | Benzocyclohetapyridiner som hæmmere af receptoren tyrosinkinase MET | |
NO20090608L (no) | Tyrosinkinaseinhibitorer | |
NO20076659L (no) | Pyrrolo(2,3-B)pyridinderivater som protein kinase inhibitorer | |
NO20084496L (no) | Pyridyl- og pyrimidinylsubstituerte pyrrol-, tiofen- og furanderivater som kinaseinhibitorer | |
WO2006124354A3 (en) | Tyrosine kinase inhibitors | |
NO20070506L (no) | Fremgangsmater og mellomprodukter nyttige for fremstilling av kondenserte heterocykliske kinase inhibitorer. | |
WO2007149427A3 (en) | Tyrosine kinase inhibitors | |
NO20061194L (no) | Mitotiske kinesininbibitorer | |
HK1135103A1 (en) | Dihydropyridine derivatives useful as protein kinase inhibitors | |
TW200407311A (en) | N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders | |
DK1791830T3 (da) | Diaminotriazol-forbindelser der er nyttige som protein-kinase-inhibitorer | |
TW200633980A (en) | Pyridones useful as inhibitors of kinases | |
SG179430A1 (en) | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | |
MX2009006700A (es) | Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas. | |
NO20023831L (no) | Pyrrol substituert 2-indolinonproteinkinaseinhibitorer | |
NO20082508L (no) | Aminopyrimidiner anvendelige som kinaseinhibitorer | |
NO20073140L (no) | Pyrrolopyraziner og pyralopyraziner som er nyttige som inhibitorer av proteinkinaser | |
NO20065727L (no) | Pyrrolinhibitorer av erk-proteinkinase, syntese derav og deres mellomprodukter | |
NO20080162L (no) | Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer | |
NO20080168L (no) | Aminoquinolin- og aminoquinoazolinkinasemodulatorer | |
NO20080174L (no) | Alkylquinolin- og alkylquinazolinkinasemodulatorer | |
NO20080161L (no) | Aminopyrimidiner som kinasemodulatorer | |
NO20092130L (no) | Tricykliske heteroarylforbindelser anvendelige som inhibitorer of januskinase | |
WO2007050380A3 (en) | Tyrosine kinase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |