HRP20020748A2 - Substituted beta-carbolines with ikb-kinase inhibiting activity - Google Patents

Substituted beta-carbolines with ikb-kinase inhibiting activity

Info

Publication number
HRP20020748A2
HRP20020748A2 HR20020748A HRP20020748A HRP20020748A2 HR P20020748 A2 HRP20020748 A2 HR P20020748A2 HR 20020748 A HR20020748 A HR 20020748A HR P20020748 A HRP20020748 A HR P20020748A HR P20020748 A2 HRP20020748 A2 HR P20020748A2
Authority
HR
Croatia
Prior art keywords
carbolines
ikb
substituted beta
inhibiting activity
kinase inhibiting
Prior art date
Application number
HR20020748A
Other languages
English (en)
Inventor
Ritzeler Olaf
Castro Alfredo
Grenier Louis
Soucy Francois
W. Hancock Wayne
Mazdiyasni Hormoz
Palombella Vito
Adams Julian
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00105514A external-priority patent/EP1134221A1/en
Priority claimed from EP00125169A external-priority patent/EP1209158A1/en
Priority claimed from PCT/EP2001/002237 external-priority patent/WO2001068648A1/en
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HRP20020748A2 publication Critical patent/HRP20020748A2/xx

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Hematology (AREA)
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  • Pain & Pain Management (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • AIDS & HIV (AREA)
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HR20020748A 2000-03-15 2002-09-12 Substituted beta-carbolines with ikb-kinase inhibiting activity HRP20020748A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00105514A EP1134221A1 (en) 2000-03-15 2000-03-15 Substituted beta-carbolines as lkB kinase inhibitors
EP00125169A EP1209158A1 (en) 2000-11-18 2000-11-18 Substituted beta-carbolines
PCT/EP2001/002237 WO2001068648A1 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Publications (1)

Publication Number Publication Date
HRP20020748A2 true HRP20020748A2 (en) 2005-02-28

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ID=26070675

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020748A HRP20020748A2 (en) 2000-03-15 2002-09-12 Substituted beta-carbolines with ikb-kinase inhibiting activity

Country Status (23)

Country Link
US (3) US6627637B2 (xx)
JP (1) JP5000828B2 (xx)
KR (1) KR100826817B1 (xx)
CN (1) CN100509810C (xx)
AT (1) ATE465161T1 (xx)
AU (2) AU3741801A (xx)
BR (1) BR0109161A (xx)
CA (1) CA2402549A1 (xx)
CZ (1) CZ301077B6 (xx)
DE (1) DE60141895D1 (xx)
EE (1) EE200200523A (xx)
HK (1) HK1054039B (xx)
HR (1) HRP20020748A2 (xx)
HU (1) HUP0300894A3 (xx)
IL (2) IL151695A0 (xx)
ME (1) MEP28108A (xx)
MX (1) MXPA02007981A (xx)
NO (1) NO324248B1 (xx)
NZ (1) NZ521386A (xx)
PL (1) PL357284A1 (xx)
RU (1) RU2277095C2 (xx)
SK (1) SK13082002A3 (xx)
YU (1) YU65502A (xx)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2402549A1 (en) * 2000-03-15 2001-09-20 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines
WO2002060386A2 (en) * 2001-02-01 2002-08-08 Bristol-Myers Squibb Company METHODS OF TREATING INFLAMMATORY AND IMMUNE DISEASES USING INHIBITORS OF IλB KINASE (IKK)
JP4599501B2 (ja) * 2001-11-07 2010-12-15 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 多発性骨髄腫および他の癌の処置におけるＩκＢのインヒビターとしてのカルボリン誘導体
US7462638B2 (en) * 2002-08-17 2008-12-09 Sanofi-Aventis Deutschland Gmbh Use of IκB-kinase inhibitors in pain therapy
US20040166095A1 (en) * 2003-02-25 2004-08-26 Blazar Bruce R. Methods for preventing GVHD
EA009121B1 (ru) * 2003-04-09 2007-10-26 Миллениум Фармасьютикалз, Инк. Бета-карболины, применяемые для лечения воспалительных заболеваний
WO2005111037A1 (en) * 2004-04-09 2005-11-24 Millennium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
US8957070B2 (en) 2005-04-20 2015-02-17 Takeda Pharmaceutical Company Limited Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
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