AU2015346460A1 - Anti-interleukin-33 antibodies and uses thereof - Google Patents

Anti-interleukin-33 antibodies and uses thereof Download PDF

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Publication number
AU2015346460A1
AU2015346460A1 AU2015346460A AU2015346460A AU2015346460A1 AU 2015346460 A1 AU2015346460 A1 AU 2015346460A1 AU 2015346460 A AU2015346460 A AU 2015346460A AU 2015346460 A AU2015346460 A AU 2015346460A AU 2015346460 A1 AU2015346460 A1 AU 2015346460A1
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Prior art keywords
amino acid
acid sequence
seq
antibody
domain
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Abandoned
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AU2015346460A
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Inventor
Jack Bevers III
Nancy Chiang
Philip E. Hass
Meredith Hazen
Yi-Chun Hsiao
Rajita KHOSLA
Gerald R. Nakamura
Dhaya Seshasayee
Menno Van Lookeren Campagne
Hongkang XI
Wenwu Zhai
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Genentech Inc
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Genentech Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
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    • C07KPEPTIDES
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    • C07K2317/54F(ab')2
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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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AU2015346460A 2014-11-10 2015-11-10 Anti-interleukin-33 antibodies and uses thereof Abandoned AU2015346460A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462077876P 2014-11-10 2014-11-10
US62/077,876 2014-11-10
US201562165732P 2015-05-22 2015-05-22
US62/165,732 2015-05-22
PCT/US2015/060008 WO2016077381A1 (en) 2014-11-10 2015-11-10 Anti-interleukin-33 antibodies and uses thereof

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Publication Number Publication Date
AU2015346460A1 true AU2015346460A1 (en) 2017-03-23

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AU2015346460A Abandoned AU2015346460A1 (en) 2014-11-10 2015-11-10 Anti-interleukin-33 antibodies and uses thereof

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US (3) US10093730B2 (enExample)
EP (2) EP3783023A1 (enExample)
JP (1) JP6929771B2 (enExample)
KR (1) KR20170080604A (enExample)
CN (1) CN107172879B (enExample)
AU (1) AU2015346460A1 (enExample)
BR (1) BR112017009728A2 (enExample)
CA (1) CA2960297A1 (enExample)
CO (1) CO2017005650A2 (enExample)
CR (1) CR20170240A (enExample)
EA (1) EA201791029A1 (enExample)
IL (1) IL251248A0 (enExample)
MX (1) MX2017006094A (enExample)
PE (1) PE20170910A1 (enExample)
PH (1) PH12017500861A1 (enExample)
SG (1) SG11201703767XA (enExample)
TW (1) TWI705976B (enExample)
WO (1) WO2016077381A1 (enExample)

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EA201791029A1 (ru) 2014-11-10 2017-12-29 Дженентек, Инк. Антитела против интерлейкина-33 и их применение
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KR20240052871A (ko) 2016-04-27 2024-04-23 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
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KR102751957B1 (ko) 2017-04-13 2025-01-09 리제너론 파마슈티칼스 인코포레이티드 Il33 및 il1rl1을 코딩하는 유전자에서의 위험 대립유전자를 갖는 환자에서의 폐 질환의 치료 및 저해
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