AU2013234496B2 - Compositions of GLP-1 peptides and preparation thereof - Google Patents

Compositions of GLP-1 peptides and preparation thereof Download PDF

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Publication number
AU2013234496B2
AU2013234496B2 AU2013234496A AU2013234496A AU2013234496B2 AU 2013234496 B2 AU2013234496 B2 AU 2013234496B2 AU 2013234496 A AU2013234496 A AU 2013234496A AU 2013234496 A AU2013234496 A AU 2013234496A AU 2013234496 B2 AU2013234496 B2 AU 2013234496B2
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Prior art keywords
ethoxy
glp
amino
peptide
hydroxybenzoyl
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AU2013234496A1 (en
Inventor
Helle Eliasen
Tue Hansen
Thomas Vilhelmsen
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Novo Nordisk AS
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Novo Nordisk AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2013234496A 2012-03-22 2013-03-15 Compositions of GLP-1 peptides and preparation thereof Active 2037-02-07 AU2013234496B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017251814A AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP12160743.6 2012-03-22
EP12160743 2012-03-22
US201361748840P 2013-01-04 2013-01-04
US61/748,840 2013-01-04
EP13153459.6 2013-01-31
EP13153459 2013-01-31
PCT/EP2013/055362 WO2013139694A1 (en) 2012-03-22 2013-03-15 Compositions of glp-1 peptides and preparation thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017251814A Division AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Publications (2)

Publication Number Publication Date
AU2013234496A1 AU2013234496A1 (en) 2014-09-11
AU2013234496B2 true AU2013234496B2 (en) 2017-07-27

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AU2017251814A Active 2037-02-07 AU2017251814B2 (en) 2012-03-22 2017-10-27 Compositions of GLP-1 peptides and preparation thereof

Family Applications After (1)

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US (6) US10933120B2 (cg-RX-API-DMAC7.html)
EP (3) EP4324475A1 (cg-RX-API-DMAC7.html)
JP (1) JP6001158B2 (cg-RX-API-DMAC7.html)
KR (1) KR102072202B1 (cg-RX-API-DMAC7.html)
CN (2) CN104203266B (cg-RX-API-DMAC7.html)
AU (2) AU2013234496B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014023374B1 (cg-RX-API-DMAC7.html)
CA (1) CA2868188A1 (cg-RX-API-DMAC7.html)
DK (1) DK2827885T3 (cg-RX-API-DMAC7.html)
ES (2) ES2690553T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20181447T1 (cg-RX-API-DMAC7.html)
HU (2) HUE039406T2 (cg-RX-API-DMAC7.html)
LT (1) LT2827885T (cg-RX-API-DMAC7.html)
MX (1) MX353067B (cg-RX-API-DMAC7.html)
MY (1) MY171146A (cg-RX-API-DMAC7.html)
PL (2) PL3488857T3 (cg-RX-API-DMAC7.html)
RS (2) RS64460B1 (cg-RX-API-DMAC7.html)
RU (1) RU2641198C3 (cg-RX-API-DMAC7.html)
SI (1) SI2827885T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800491T1 (cg-RX-API-DMAC7.html)
WO (1) WO2013139694A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201406250B (cg-RX-API-DMAC7.html)

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SMT201800491T1 (it) 2018-11-09
EP3488857A1 (en) 2019-05-29
CA2868188A1 (en) 2013-09-26
CN104203266B (zh) 2017-12-26
US20150072926A1 (en) 2015-03-12
US20250195618A1 (en) 2025-06-19
EP3488857B9 (en) 2023-10-04
SI2827885T1 (sl) 2018-10-30

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