AU2007237482B2 - Synthesis of acylaminoalkenylene amides useful as substance p antagonists - Google Patents

Synthesis of acylaminoalkenylene amides useful as substance p antagonists Download PDF

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Publication number
AU2007237482B2
AU2007237482B2 AU2007237482A AU2007237482A AU2007237482B2 AU 2007237482 B2 AU2007237482 B2 AU 2007237482B2 AU 2007237482 A AU2007237482 A AU 2007237482A AU 2007237482 A AU2007237482 A AU 2007237482A AU 2007237482 B2 AU2007237482 B2 AU 2007237482B2
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AU
Australia
Prior art keywords
formula
compound
protecting group
boc protecting
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007237482A
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English (en)
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AU2007237482A1 (en
Inventor
Robert Portmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
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Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0607532A external-priority patent/GB0607532D0/en
Priority claimed from GB0610244A external-priority patent/GB0610244D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2007237482A1 publication Critical patent/AU2007237482A1/en
Application granted granted Critical
Publication of AU2007237482B2 publication Critical patent/AU2007237482B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007237482A 2006-04-13 2007-04-11 Synthesis of acylaminoalkenylene amides useful as substance p antagonists Ceased AU2007237482B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0607532A GB0607532D0 (en) 2006-04-13 2006-04-13 Organic compounds
GB0607532.9 2006-04-13
GB0610244A GB0610244D0 (en) 2006-05-23 2006-05-23 Organic compounds
GB0610244.6 2006-05-23
PCT/EP2007/003213 WO2007118651A1 (en) 2006-04-13 2007-04-11 Synthesis of acylaminoalkenylene amides useful as substance p antagonists

Publications (2)

Publication Number Publication Date
AU2007237482A1 AU2007237482A1 (en) 2007-10-25
AU2007237482B2 true AU2007237482B2 (en) 2011-03-17

Family

ID=38324102

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007237482A Ceased AU2007237482B2 (en) 2006-04-13 2007-04-11 Synthesis of acylaminoalkenylene amides useful as substance p antagonists

Country Status (28)

Country Link
US (2) US8008479B2 (enExample)
EP (1) EP2010498B1 (enExample)
JP (1) JP5208917B2 (enExample)
KR (1) KR20080108291A (enExample)
AR (1) AR060506A1 (enExample)
AT (1) ATE486853T1 (enExample)
AU (1) AU2007237482B2 (enExample)
CA (1) CA2645362C (enExample)
CL (1) CL2007001040A1 (enExample)
CY (1) CY1111294T1 (enExample)
DE (1) DE602007010269D1 (enExample)
DK (1) DK2010498T3 (enExample)
EC (1) ECSP088820A (enExample)
GT (1) GT200800209A (enExample)
HR (1) HRP20110045T1 (enExample)
JO (1) JO2630B1 (enExample)
MA (1) MA30394B1 (enExample)
MX (1) MX2008013117A (enExample)
MY (1) MY145069A (enExample)
NO (1) NO20084783L (enExample)
NZ (1) NZ571142A (enExample)
PE (1) PE20071223A1 (enExample)
PL (1) PL2010498T3 (enExample)
PT (1) PT2010498E (enExample)
RU (1) RU2433122C2 (enExample)
SI (1) SI2010498T1 (enExample)
TW (1) TW200815358A (enExample)
WO (1) WO2007118651A1 (enExample)

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DE102009001446A1 (de) 2009-03-10 2010-09-23 Evonik Rohmax Additives Gmbh Verwendung von Kammpolymeren als Antifatigue-Additive
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JP2012531419A (ja) 2009-06-23 2012-12-10 コンサート ファーマシューティカルズ インコーポレイテッド Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体
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DE102010001040A1 (de) 2010-01-20 2011-07-21 Evonik RohMax Additives GmbH, 64293 (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007694A1 (en) * 1996-08-22 1998-02-26 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
CZ288345B6 (en) * 1995-02-22 2001-05-16 Novartis Ag Arylacylaminoethanes, process of their preparation and pharmaceutical preparation in which they are comprised
GB0010958D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1998007694A1 (en) * 1996-08-22 1998-02-26 Novartis Ag Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Also Published As

Publication number Publication date
US8008479B2 (en) 2011-08-30
AR060506A1 (es) 2008-06-25
EP2010498A1 (en) 2009-01-07
PE20071223A1 (es) 2008-01-22
NZ571142A (en) 2011-02-25
PL2010498T3 (pl) 2011-04-29
MY145069A (en) 2011-12-15
PT2010498E (pt) 2011-02-08
CL2007001040A1 (es) 2008-03-14
US20090137797A1 (en) 2009-05-28
DK2010498T3 (da) 2011-02-14
EP2010498B1 (en) 2010-11-03
MX2008013117A (es) 2008-10-21
NO20084783L (no) 2008-11-12
US20110282053A1 (en) 2011-11-17
SI2010498T1 (sl) 2011-03-31
JP5208917B2 (ja) 2013-06-12
ECSP088820A (es) 2008-11-27
TW200815358A (en) 2008-04-01
RU2008145102A (ru) 2010-05-27
HK1125640A1 (en) 2009-08-14
MA30394B1 (fr) 2009-05-04
JP2009533369A (ja) 2009-09-17
CY1111294T1 (el) 2015-08-05
JO2630B1 (en) 2012-06-17
RU2433122C2 (ru) 2011-11-10
AU2007237482A1 (en) 2007-10-25
CA2645362C (en) 2013-07-16
GT200800209A (es) 2008-12-15
KR20080108291A (ko) 2008-12-12
ATE486853T1 (de) 2010-11-15
HRP20110045T1 (hr) 2011-02-28
DE602007010269D1 (de) 2010-12-16
WO2007118651A1 (en) 2007-10-25
CA2645362A1 (en) 2007-10-25

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