HRP20110045T1 - Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p - Google Patents
Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p Download PDFInfo
- Publication number
- HRP20110045T1 HRP20110045T1 HR20110045T HRP20110045T HRP20110045T1 HR P20110045 T1 HRP20110045 T1 HR P20110045T1 HR 20110045 T HR20110045 T HR 20110045T HR P20110045 T HRP20110045 T HR P20110045T HR P20110045 T1 HRP20110045 T1 HR P20110045T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- protecting group
- boc protecting
- image
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
| GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
| PCT/EP2007/003213 WO2007118651A1 (en) | 2006-04-13 | 2007-04-11 | Synthesis of acylaminoalkenylene amides useful as substance p antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110045T1 true HRP20110045T1 (hr) | 2011-02-28 |
Family
ID=38324102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110045T HRP20110045T1 (hr) | 2006-04-13 | 2007-04-11 | Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8008479B2 (enExample) |
| EP (1) | EP2010498B1 (enExample) |
| JP (1) | JP5208917B2 (enExample) |
| KR (1) | KR20080108291A (enExample) |
| AR (1) | AR060506A1 (enExample) |
| AT (1) | ATE486853T1 (enExample) |
| AU (1) | AU2007237482B2 (enExample) |
| CA (1) | CA2645362C (enExample) |
| CL (1) | CL2007001040A1 (enExample) |
| CY (1) | CY1111294T1 (enExample) |
| DE (1) | DE602007010269D1 (enExample) |
| DK (1) | DK2010498T3 (enExample) |
| EC (1) | ECSP088820A (enExample) |
| GT (1) | GT200800209A (enExample) |
| HR (1) | HRP20110045T1 (enExample) |
| JO (1) | JO2630B1 (enExample) |
| MA (1) | MA30394B1 (enExample) |
| MX (1) | MX2008013117A (enExample) |
| MY (1) | MY145069A (enExample) |
| NO (1) | NO20084783L (enExample) |
| NZ (1) | NZ571142A (enExample) |
| PE (1) | PE20071223A1 (enExample) |
| PL (1) | PL2010498T3 (enExample) |
| PT (1) | PT2010498E (enExample) |
| RU (1) | RU2433122C2 (enExample) |
| SI (1) | SI2010498T1 (enExample) |
| TW (1) | TW200815358A (enExample) |
| WO (1) | WO2007118651A1 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790699B2 (en) | 2004-10-12 | 2010-09-07 | Fmc Biopolymer As | Self-gelling alginate systems and uses thereof |
| AU2006275595B2 (en) | 2005-07-29 | 2012-08-16 | Concert Pharmaceuticals Inc. | Novel benzo [d] [1,3]-dioxol derivatives |
| US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
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| US8080549B2 (en) | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| US8013007B2 (en) | 2007-02-26 | 2011-09-06 | Concert Pharmaceuticals, Inc. | Alpha 1A-adrenoceptor antagonists |
| ES2395241T3 (es) | 2007-03-07 | 2013-02-11 | Concert Pharmaceuticals Inc. | Derivados deuterados de piperazina como compuestos antianginosos |
| US8759383B2 (en) | 2007-03-16 | 2014-06-24 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
| WO2008128166A1 (en) | 2007-04-13 | 2008-10-23 | Concert Pharmaceuticals Inc. | Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds |
| US8349817B2 (en) | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
| EP2527336A1 (en) | 2007-04-25 | 2012-11-28 | Concert Pharmaceuticals Inc. | Deuterated analogues of cilostazol |
| PT2522668E (pt) | 2007-05-01 | 2015-06-09 | Concert Pharmaceuticals Inc | Compostos de morfinano |
| CN102718710B (zh) | 2007-05-01 | 2014-11-05 | 康塞特医药品公司 | 吗啡烷化合物 |
| US7820666B2 (en) | 2007-05-08 | 2010-10-26 | Concert Pharmaceuticals, Inc. | Tetrahydrotriazolopyrazine derivatives and uses thereof |
| DE602008000255D1 (de) | 2007-06-12 | 2009-12-17 | Concert Pharmaceuticals Inc | Azapeptid-Derivate als HIV-Protease-Inhibitoren |
| US7687509B2 (en) | 2007-07-09 | 2010-03-30 | Concert Pharmaceuticals Inc. | Pyrimidinecarboxamide derivatives |
| EP2190841B1 (en) | 2007-08-14 | 2013-05-15 | Concert Pharmaceuticals Inc. | Substituted oxazolidinone derivatives |
| BRPI0815977A2 (pt) | 2007-08-28 | 2017-06-13 | Fmc Corp | dispersão, kit e composição para fabricar a mesma, métodos para dispensar uma dispersão de alginato auto-geleificante retardada, para preparar um gel de alginato e para preparar alginato insolúvel/ partículas de íon geleificante, e, alginato ultrapuro insolúvel/partículas de íon geleificante. |
| EP2197847B1 (en) | 2007-09-12 | 2012-11-07 | Concert Pharmaceuticals Inc. | Deuterated 4 -oxoquinoline derivative for the treatment of hiv infection |
| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| EP2212298B1 (en) | 2007-10-18 | 2013-03-27 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| US8592487B2 (en) | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
| EP2231155A4 (en) | 2007-12-18 | 2011-09-14 | Concert Pharmaceuticals Inc | Tetrahydroisoquinoline DERIVATIVES |
| WO2009094216A1 (en) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Derivatives of gefitinib |
| WO2009094210A1 (en) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Vandetanib derivatives |
| WO2009108383A2 (en) | 2008-02-29 | 2009-09-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8367674B2 (en) | 2008-04-17 | 2013-02-05 | Concert Pharmaceuticals, Inc. | Piperazine derivatives |
| US8354557B2 (en) | 2008-06-17 | 2013-01-15 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated morpholine derivatives |
| MX2011002278A (es) | 2008-08-29 | 2011-04-14 | Concert Pharmaceuticals Inc | Derivados de triazolo-piridazina sustituidos. |
| EP2334621A1 (en) | 2008-09-16 | 2011-06-22 | Concert Pharmaceuticals, Inc. | Deuterated 2-amino-3-hydroxypropanoic acid derivatives |
| ES2575086T3 (es) | 2008-09-19 | 2016-06-24 | Concert Pharmaceuticals Inc. | Compuestos de morfinano deuterados |
| US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| SG173758A1 (en) * | 2009-02-24 | 2011-09-29 | Novartis Ag | Uses of nk receptor antagonists |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| DE102009001446A1 (de) | 2009-03-10 | 2010-09-23 | Evonik Rohmax Additives Gmbh | Verwendung von Kammpolymeren als Antifatigue-Additive |
| US8563554B2 (en) | 2009-03-17 | 2013-10-22 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| WO2010108103A1 (en) * | 2009-03-19 | 2010-09-23 | Concert Pharmaceuticals, Inc. | Azepan-2-one derivatives |
| WO2010124046A1 (en) | 2009-04-23 | 2010-10-28 | Concert Pharmaceuticals, Inc. | 4-hydroxybutyric acid analogs |
| US8410082B2 (en) | 2009-05-22 | 2013-04-02 | Concert Pharmaceuticals, Inc. | Fluorinated diaryl urea derivatives |
| HRP20140520T1 (hr) | 2009-06-18 | 2014-07-04 | Concert Pharmaceuticals Inc. | Deuterirani derivati izoindolin-1,3-diona kao inhibitori pde4 i tnf-alfa |
| JP2012531419A (ja) | 2009-06-23 | 2012-12-10 | コンサート ファーマシューティカルズ インコーポレイテッド | Ｇａｂａ−ａ受容体修飾物質としての重水素修飾されたトリアゾロピリダジン誘導体 |
| WO2011020044A1 (en) | 2009-08-14 | 2011-02-17 | Concert Pharmaceuticals, Inc. | Substituted triazolophthalazine derivatives |
| WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US9260432B2 (en) | 2009-09-02 | 2016-02-16 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
| WO2011047315A1 (en) | 2009-10-15 | 2011-04-21 | Concert Pharmaceuticals, Inc. | Subsitituted benzimidazoles |
| US8471034B2 (en) | 2009-11-18 | 2013-06-25 | Concert Pharmaceuticals, Inc. | Niacin prodrugs and deuterated versions thereof |
| DE102010001040A1 (de) | 2010-01-20 | 2011-07-21 | Evonik RohMax Additives GmbH, 64293 | (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| WO2011109464A1 (en) | 2010-03-02 | 2011-09-09 | Concert Pharmaceuticals Inc. | Deuterated tetrahydronaphthalene derivatives |
| US9226801B2 (en) * | 2010-03-08 | 2016-01-05 | Ibur, Llc | Custom linkable imaging and multifunctional tray |
| WO2011116066A1 (en) | 2010-03-17 | 2011-09-22 | Concert Pharmaceuticals, Inc. | Derivatives of dimethylcurcumin |
| US9107922B2 (en) | 2010-07-16 | 2015-08-18 | Concert Pharmaceuticals, Inc. | Pyrimidinecarboxamide derivatives |
| WO2012031072A1 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| WO2012031073A1 (en) | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| CN103370289B (zh) | 2011-02-14 | 2015-09-09 | 康塞特医药品有限公司 | 4-羟基丁酸氘化类似物 |
| US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| US8889687B2 (en) | 2011-03-04 | 2014-11-18 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| MX2014012384A (es) | 2012-04-13 | 2014-11-26 | Concert Pharmaceuticals Inc | Derivados sustituidos de xantina. |
| EP2838879A1 (en) | 2012-04-20 | 2015-02-25 | Concert Pharmaceuticals Inc. | Deuterated rigosertib |
| CA2876306C (en) | 2012-06-15 | 2024-02-20 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
| US9181190B2 (en) | 2012-07-04 | 2015-11-10 | Concert Pharmaceuticals, Inc. | Deuterated vercirnon |
| ES2694202T3 (es) | 2012-07-12 | 2018-12-19 | Concert Pharmaceuticals, Inc. | Idebenona deuterada |
| CA2879400A1 (en) | 2012-07-30 | 2014-02-06 | Concert Pharmaceuticals, Inc. | Deuterated ibrutinib |
| EA031716B1 (ru) | 2012-08-17 | 2019-02-28 | Консерт Фармасьютикалс, Инк. | Дейтерированный барицитиниб |
| WO2014066243A1 (en) | 2012-10-22 | 2014-05-01 | Concert Pharmaceuticals, Inc. | Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} |
| WO2014110189A1 (en) | 2013-01-09 | 2014-07-17 | Concert Pharmaceuticals Inc. | Deuterated momelotinib |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9676790B2 (en) | 2013-08-30 | 2017-06-13 | Concert Pharmaceuticals, Inc. | Substituted thienotriazolodiazapines |
| US9694017B2 (en) | 2014-02-10 | 2017-07-04 | Concert Pharmaceuticals, Inc. | Substituted triazolobenzodiazepines |
| US10160778B2 (en) | 2014-10-27 | 2018-12-25 | Concert Pharmaceuticals, Inc. | Pyrimidine phosphonic acid esters |
| WO2016160945A1 (en) | 2015-03-31 | 2016-10-06 | Concert Pharmaceuticals, Inc. | Deuterated vx-661 |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| AU2016327603B2 (en) | 2015-09-25 | 2021-04-22 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR potentiators |
| US11267777B2 (en) | 2015-11-19 | 2022-03-08 | Concert Pharmaceuticals, Inc. | Deuterated EPI-743 |
| EP3416629A4 (en) | 2016-02-16 | 2019-08-07 | CoNCERT Pharmaceuticals, Inc. | DEUTERATED GFT-505 |
| IL322463A (en) | 2017-11-22 | 2025-09-01 | Sun Pharmaceutical Ind Inc | Deuterated d-serine analogs and their uses |
| HRP20241608T1 (hr) | 2017-12-01 | 2025-01-31 | Vertex Pharmaceuticals Incorporated | Postupci za proizvodnju modulatora transmembranskog regulatora provodljivosti cistične fibroze |
| US12065395B2 (en) | 2019-04-03 | 2024-08-20 | Sun Pharmaceutical Industries, Inc. | Processes for the preparation of deuterated D-serine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ288345B6 (en) * | 1995-02-22 | 2001-05-16 | Novartis Ag | Arylacylaminoethanes, process of their preparation and pharmaceutical preparation in which they are comprised |
| MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB0010958D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Ceased
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en not_active Ceased
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en active Active
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2011
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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