ECSP088820A - Síntesis de acil-amino-alquenilen-amidas utiles como antagonistas de la sustancia p. - Google Patents
Síntesis de acil-amino-alquenilen-amidas utiles como antagonistas de la sustancia p.Info
- Publication number
- ECSP088820A ECSP088820A EC2008008820A ECSP088820A ECSP088820A EC SP088820 A ECSP088820 A EC SP088820A EC 2008008820 A EC2008008820 A EC 2008008820A EC SP088820 A ECSP088820 A EC SP088820A EC SP088820 A ECSP088820 A EC SP088820A
- Authority
- EC
- Ecuador
- Prior art keywords
- substance
- useful
- alquenilen
- amidas
- acil
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
- 102100024304 Protachykinin-1 Human genes 0.000 abstract 1
- 101800003906 Substance P Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
| GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088820A true ECSP088820A (es) | 2008-11-27 |
Family
ID=38324102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008820A ECSP088820A (es) | 2006-04-13 | 2008-10-13 | Síntesis de acil-amino-alquenilen-amidas utiles como antagonistas de la sustancia p. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8008479B2 (enExample) |
| EP (1) | EP2010498B1 (enExample) |
| JP (1) | JP5208917B2 (enExample) |
| KR (1) | KR20080108291A (enExample) |
| AR (1) | AR060506A1 (enExample) |
| AT (1) | ATE486853T1 (enExample) |
| AU (1) | AU2007237482B2 (enExample) |
| CA (1) | CA2645362C (enExample) |
| CL (1) | CL2007001040A1 (enExample) |
| CY (1) | CY1111294T1 (enExample) |
| DE (1) | DE602007010269D1 (enExample) |
| DK (1) | DK2010498T3 (enExample) |
| EC (1) | ECSP088820A (enExample) |
| GT (1) | GT200800209A (enExample) |
| HR (1) | HRP20110045T1 (enExample) |
| JO (1) | JO2630B1 (enExample) |
| MA (1) | MA30394B1 (enExample) |
| MX (1) | MX2008013117A (enExample) |
| MY (1) | MY145069A (enExample) |
| NO (1) | NO20084783L (enExample) |
| NZ (1) | NZ571142A (enExample) |
| PE (1) | PE20071223A1 (enExample) |
| PL (1) | PL2010498T3 (enExample) |
| PT (1) | PT2010498E (enExample) |
| RU (1) | RU2433122C2 (enExample) |
| SI (1) | SI2010498T1 (enExample) |
| TW (1) | TW200815358A (enExample) |
| WO (1) | WO2007118651A1 (enExample) |
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| EA031716B1 (ru) | 2012-08-17 | 2019-02-28 | Консерт Фармасьютикалс, Инк. | Дейтерированный барицитиниб |
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| IL322463A (en) | 2017-11-22 | 2025-09-01 | Sun Pharmaceutical Ind Inc | Deuterated d-serine analogs and their uses |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ288345B6 (en) * | 1995-02-22 | 2001-05-16 | Novartis Ag | Arylacylaminoethanes, process of their preparation and pharmaceutical preparation in which they are comprised |
| MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB0010958D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Ceased
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en not_active Ceased
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en active Active
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2011
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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